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Volumn 23, Issue 2, 2013, Pages 99-108

Heterochromatin instability in cancer: From the Barr body to satellites and the nuclear periphery

Author keywords

BRCA1; Cancer; Epigenetics; Heterochromatin; Satellite DNA; XIST

Indexed keywords

BRCA1 PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; SATELLITE DNA;

EID: 84875619696     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2012.06.008     Document Type: Review
Times cited : (80)

References (98)
  • 1
    • 0024384664 scopus 로고
    • Cancer as a disease of DNA organization and dynamic cell structure
    • Pienta K.J., Partin A.W., Coffey D.S. Cancer as a disease of DNA organization and dynamic cell structure. Cancer Research 1989, 49:2525-2532.
    • (1989) Cancer Research , vol.49 , pp. 2525-2532
    • Pienta, K.J.1    Partin, A.W.2    Coffey, D.S.3
  • 5
    • 64049119754 scopus 로고    scopus 로고
    • In search of nonribosomal nucleolar protein function and regulation
    • Pederson T., Tsai R.Y.L. In search of nonribosomal nucleolar protein function and regulation. The Journal of Cell Biology 2009, 184:771-776.
    • (2009) The Journal of Cell Biology , vol.184 , pp. 771-776
    • Pederson, T.1    Tsai, R.Y.L.2
  • 6
    • 84885475952 scopus 로고    scopus 로고
    • Nuclear bodies
    • Spector D. Nuclear bodies. Cell 2006, 127:1020.
    • (2006) Cell , vol.127 , pp. 1020
    • Spector, D.1
  • 7
    • 84861975139 scopus 로고    scopus 로고
    • Nuclear bodies: multifunctional companions of the genome
    • Dundr M. Nuclear bodies: multifunctional companions of the genome. Current Opinion in Cell Biology 2012, 24:1-8.
    • (2012) Current Opinion in Cell Biology , vol.24 , pp. 1-8
    • Dundr, M.1
  • 10
    • 0027418252 scopus 로고
    • Higher level organization of individual gene transcription and RNA splicing
    • Xing Y., Johnson C.V., Dobner P.R., Lawrence J.B. Higher level organization of individual gene transcription and RNA splicing. Science 1993, 259:1326-1330.
    • (1993) Science , vol.259 , pp. 1326-1330
    • Xing, Y.1    Johnson, C.V.2    Dobner, P.R.3    Lawrence, J.B.4
  • 13
    • 70249136846 scopus 로고    scopus 로고
    • Chromosome crosstalk in three dimensions
    • Göndör A., Ohlsson R. Chromosome crosstalk in three dimensions. Nature 2009, 461:212-217.
    • (2009) Nature , vol.461 , pp. 212-217
    • Göndör, A.1    Ohlsson, R.2
  • 14
    • 52249097416 scopus 로고    scopus 로고
    • Gene associations: true romance or chance meeting in a nuclear neighborhood?
    • Lawrence J.B., Clemson C.M. Gene associations: true romance or chance meeting in a nuclear neighborhood?. The Journal of Cell Biology 2008, 182:1035-1038.
    • (2008) The Journal of Cell Biology , vol.182 , pp. 1035-1038
    • Lawrence, J.B.1    Clemson, C.M.2
  • 15
    • 30944469000 scopus 로고    scopus 로고
    • Coregulated human globin genes are frequently in spatial proximity when active
    • Brown J.M. Coregulated human globin genes are frequently in spatial proximity when active. The Journal of Cell Biology 2006, 172:177-187.
    • (2006) The Journal of Cell Biology , vol.172 , pp. 177-187
    • Brown, J.M.1
  • 16
    • 0141706933 scopus 로고    scopus 로고
    • Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods
    • Shopland L.S., Johnson C.V., Byron M., McNeil J., Lawrence J.B. Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods. Journal of Cell Biology 2003, 162:981-990.
    • (2003) Journal of Cell Biology , vol.162 , pp. 981-990
    • Shopland, L.S.1    Johnson, C.V.2    Byron, M.3    McNeil, J.4    Lawrence, J.B.5
  • 17
    • 33744542916 scopus 로고    scopus 로고
    • Close encounters between active genes in the nucleus
    • Chuang C.-H., Belmont A.S. Close encounters between active genes in the nucleus. Genome Biology 2005, 6:237.
    • (2005) Genome Biology , vol.6 , pp. 237
    • Chuang, C.-H.1    Belmont, A.S.2
  • 18
    • 45149084413 scopus 로고    scopus 로고
    • Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
    • Guelen L., Pagie L., Brasset E., Meuleman W., Faza M.B., Talhout W., et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature 2008, 453:948.
    • (2008) Nature , vol.453 , pp. 948
    • Guelen, L.1    Pagie, L.2    Brasset, E.3    Meuleman, W.4    Faza, M.B.5    Talhout, W.6
  • 19
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • Reddy K.L., Zullo J.M., Bertolino E., Singh H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008, 452:243.
    • (2008) Nature , vol.452 , pp. 243
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 20
    • 38349043904 scopus 로고    scopus 로고
    • A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence
    • Kumaran R.I., Spector D.L. A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. The Journal of Cell Biology 2008, 180:51-65.
    • (2008) The Journal of Cell Biology , vol.180 , pp. 51-65
    • Kumaran, R.I.1    Spector, D.L.2
  • 22
    • 0034631851 scopus 로고    scopus 로고
    • Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments
    • Kruhlak M.J., Lever M.A., Fischle W., Verdin E., Bazett-Jones D.P., Hendzel M.J. Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments. Journal of Cell Biology 2000, 150:41-51.
    • (2000) Journal of Cell Biology , vol.150 , pp. 41-51
    • Kruhlak, M.J.1    Lever, M.A.2    Fischle, W.3    Verdin, E.4    Bazett-Jones, D.P.5    Hendzel, M.J.6
  • 23
    • 0034611785 scopus 로고    scopus 로고
    • High mobility of proteins in the mammalian cell nucleus
    • Phair R.D., Misteli T. High mobility of proteins in the mammalian cell nucleus. Nature 2000, 404:604-609.
    • (2000) Nature , vol.404 , pp. 604-609
    • Phair, R.D.1    Misteli, T.2
  • 24
    • 0034631850 scopus 로고    scopus 로고
    • Seeking common ground in nuclear complexity
    • Shopland L.S. Seeking common ground in nuclear complexity. The Journal of Cell Biology 2000, 150:1F-4F.
    • (2000) The Journal of Cell Biology , vol.150
    • Shopland, L.S.1
  • 26
    • 78349274999 scopus 로고    scopus 로고
    • Hsp70 gene association with nuclear speckles is Hsp70 promoter specific
    • Hu Y., Plutz M., Belmont A.S. Hsp70 gene association with nuclear speckles is Hsp70 promoter specific. The Journal of Cell Biology 2010, 191:711-719.
    • (2010) The Journal of Cell Biology , vol.191 , pp. 711-719
    • Hu, Y.1    Plutz, M.2    Belmont, A.S.3
  • 28
    • 0029122344 scopus 로고
    • Compartmentalization of specific pre-mRNA metabolism: an emerging view
    • Moen P., Smith K., Lawrence J. Compartmentalization of specific pre-mRNA metabolism: an emerging view. Human Molecular Genetics 1995, 4 Spec No:1779-1789.
    • (1995) Human Molecular Genetics , vol.4 SPEC. NO. , pp. 1779-1789
    • Moen, P.1    Smith, K.2    Lawrence, J.3
  • 29
    • 0035889085 scopus 로고    scopus 로고
    • The concept of self-organization in cellular architecture
    • Misteli T. The concept of self-organization in cellular architecture. The Journal of Cell Biology 2001, 155:181-186.
    • (2001) The Journal of Cell Biology , vol.155 , pp. 181-186
    • Misteli, T.1
  • 31
    • 0035110880 scopus 로고    scopus 로고
    • Experimental observations of a nuclear matrix
    • Nickerson J. Experimental observations of a nuclear matrix. Journal of Cell Science 2001, 114:463-474.
    • (2001) Journal of Cell Science , vol.114 , pp. 463-474
    • Nickerson, J.1
  • 33
    • 0019169859 scopus 로고
    • Supercoiled loops and eukaryotic DNA replication
    • Vogelstein B., Pardoll D.M., Coffey D.S. Supercoiled loops and eukaryotic DNA replication. Cell 1980, 22:79-85.
    • (1980) Cell , vol.22 , pp. 79-85
    • Vogelstein, B.1    Pardoll, D.M.2    Coffey, D.S.3
  • 34
    • 0028228354 scopus 로고
    • Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos
    • Gerdes M.G., Carter K.C., Moen P.T., Lawrence J.B. Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos. The Journal of Cell Biology 1994, 126:289-304.
    • (1994) The Journal of Cell Biology , vol.126 , pp. 289-304
    • Gerdes, M.G.1    Carter, K.C.2    Moen, P.T.3    Lawrence, J.B.4
  • 35
    • 77249162266 scopus 로고    scopus 로고
    • Maintenance of a functional higher order chromatin structure: the role of the nuclear matrix in normal and disease states
    • Linnemann A.K., Krawetz S.A. Maintenance of a functional higher order chromatin structure: the role of the nuclear matrix in normal and disease states. Gene Therapy & Molecular Biology 2009, 13:231.
    • (2009) Gene Therapy & Molecular Biology , vol.13 , pp. 231
    • Linnemann, A.K.1    Krawetz, S.A.2
  • 38
    • 66249142327 scopus 로고    scopus 로고
    • Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity
    • Linnemann A.K., Krawetz S.A. Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity. Nucleic Acids Research 2009, 37:2779-2788.
    • (2009) Nucleic Acids Research , vol.37 , pp. 2779-2788
    • Linnemann, A.K.1    Krawetz, S.A.2
  • 39
    • 40749094918 scopus 로고    scopus 로고
    • SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
    • Han H.J., Russo J., Kohwi Y., Kohwi-Shigematsu T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 2008, 452:187-193.
    • (2008) Nature , vol.452 , pp. 187-193
    • Han, H.J.1    Russo, J.2    Kohwi, Y.3    Kohwi-Shigematsu, T.4
  • 40
    • 67650047792 scopus 로고    scopus 로고
    • Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells
    • Butler J.T., Hall L.L., Smith K.P., Lawrence J.B. Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells. Journal of Cellular Biochemistry 2009, 107:609-621.
    • (2009) Journal of Cellular Biochemistry , vol.107 , pp. 609-621
    • Butler, J.T.1    Hall, L.L.2    Smith, K.P.3    Lawrence, J.B.4
  • 43
    • 33746073030 scopus 로고    scopus 로고
    • PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase
    • Luciani J.J., Depetris D., Usson Y., Metzler-Guillemain C., Mignon-Ravix C., Mitchell M.J., et al. PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase. Journal of Cell Science 2006, 119:2518-2531.
    • (2006) Journal of Cell Science , vol.119 , pp. 2518-2531
    • Luciani, J.J.1    Depetris, D.2    Usson, Y.3    Metzler-Guillemain, C.4    Mignon-Ravix, C.5    Mitchell, M.J.6
  • 44
  • 45
    • 0030034051 scopus 로고    scopus 로고
    • XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure
    • Clemson C.M., McNeil J.A., Willard H.F., Lawrence J.B. XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. Journal of Cell Biology 1996, 132:259-275.
    • (1996) Journal of Cell Biology , vol.132 , pp. 259-275
    • Clemson, C.M.1    McNeil, J.A.2    Willard, H.F.3    Lawrence, J.B.4
  • 46
    • 0026456701 scopus 로고
    • The human XIST gene: analysis of a 17kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
    • Brown C., Hendrich B., Rupert J., Lafreniere R. The human XIST gene: analysis of a 17kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 1992, 78. 10.1016/0092-8674(92)90520-M.
    • (1992) Cell , pp. 78
    • Brown, C.1    Hendrich, B.2    Rupert, J.3    Lafreniere, R.4
  • 47
    • 0026489906 scopus 로고
    • The product of the mouse Xist gene is a 15kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
    • Brockdorff N., Ashworth A., Kay G.F., McCabe V.M., Norris D.P., Cooper P.J., et al. The product of the mouse Xist gene is a 15kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 1992, 71:515-526.
    • (1992) Cell , vol.71 , pp. 515-526
    • Brockdorff, N.1    Ashworth, A.2    Kay, G.F.3    McCabe, V.M.4    Norris, D.P.5    Cooper, P.J.6
  • 48
    • 24344454298 scopus 로고    scopus 로고
    • Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome
    • Heard E. Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome. Current Opinion in Genetics and Development 2005, 15:482-489.
    • (2005) Current Opinion in Genetics and Development , vol.15 , pp. 482-489
    • Heard, E.1
  • 49
    • 0035473989 scopus 로고    scopus 로고
    • Forty years of decoding the silence in X-chromosome inactivation
    • Boumil R.M., Lee J.T. Forty years of decoding the silence in X-chromosome inactivation. Human Molecular Genetics 2001, 10:2225-2232.
    • (2001) Human Molecular Genetics , vol.10 , pp. 2225-2232
    • Boumil, R.M.1    Lee, J.T.2
  • 50
    • 80052423475 scopus 로고    scopus 로고
    • XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome
    • Hall L.L., Lawrence J.B. XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome. Cold Spring Harbor Symposia on Quantitative Biology 2010, 75:345-356.
    • (2010) Cold Spring Harbor Symposia on Quantitative Biology , vol.75 , pp. 345-356
    • Hall, L.L.1    Lawrence, J.B.2
  • 51
    • 0035858882 scopus 로고    scopus 로고
    • Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation
    • Csankovszki G., Nagy A., Jaenisch R. Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. The Journal of Cell Biology 2001, 153:773-784.
    • (2001) The Journal of Cell Biology , vol.153 , pp. 773-784
    • Csankovszki, G.1    Nagy, A.2    Jaenisch, R.3
  • 52
    • 0036898974 scopus 로고    scopus 로고
    • Unbalanced X; autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin
    • Hall L.L., Clemson C.M., Byron M., Wydner K., Lawrence J.B. Unbalanced X; autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin. Human Molecular Genetics 2002, 11:3157-3165.
    • (2002) Human Molecular Genetics , vol.11 , pp. 3157-3165
    • Hall, L.L.1    Clemson, C.M.2    Byron, M.3    Wydner, K.4    Lawrence, J.B.5
  • 53
    • 0028212159 scopus 로고
    • The human X-inactivation centre is not required for maintenance of X-chromosome inactivation
    • Brown C.J., Willard H.F. The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature 1994, 368:154-156.
    • (1994) Nature , vol.368 , pp. 154-156
    • Brown, C.J.1    Willard, H.F.2
  • 55
    • 0018841647 scopus 로고
    • Further studies on the prognostic importance of Barr body frequency in human breast cancer: with discussion on its probable mechanism
    • Borah V., Shah P.N., Ghosh S.N., Sampat M.B., Jussawalla D.J. Further studies on the prognostic importance of Barr body frequency in human breast cancer: with discussion on its probable mechanism. Journal of Surgical Oncology 1980, 13:1-7.
    • (1980) Journal of Surgical Oncology , vol.13 , pp. 1-7
    • Borah, V.1    Shah, P.N.2    Ghosh, S.N.3    Sampat, M.B.4    Jussawalla, D.J.5
  • 57
    • 4444381577 scopus 로고    scopus 로고
    • Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
    • Kawakami T., Zhang C., Taniguchi T., Kim C.J., Okada Y., Sugihara H., et al. Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells. Oncogene 2004, 23:6163-6169.
    • (2004) Oncogene , vol.23 , pp. 6163-6169
    • Kawakami, T.1    Zhang, C.2    Taniguchi, T.3    Kim, C.J.4    Okada, Y.5    Sugihara, H.6
  • 59
    • 20144389742 scopus 로고    scopus 로고
    • Loss of the inactive X chromosome and replication of the active X in BRCA1-defective and wild-type breast cancer cells
    • Sirchia S.M. Loss of the inactive X chromosome and replication of the active X in BRCA1-defective and wild-type breast cancer cells. Cancer Research 2005, 65:2139-2146.
    • (2005) Cancer Research , vol.65 , pp. 2139-2146
    • Sirchia, S.M.1
  • 60
    • 34547100782 scopus 로고    scopus 로고
    • Global analysis of chromosome X gene expression in primary cultures of normal ovarian surface epithelial cells and epithelial ovarian cancer cell lines
    • Benoît M., Hudson T., Maire G., Squire J., Arcand S., Provencher D., et al. Global analysis of chromosome X gene expression in primary cultures of normal ovarian surface epithelial cells and epithelial ovarian cancer cell lines. International Journal of Oncology 2007, 30:5-17.
    • (2007) International Journal of Oncology , vol.30 , pp. 5-17
    • Benoît, M.1    Hudson, T.2    Maire, G.3    Squire, J.4    Arcand, S.5    Provencher, D.6
  • 61
    • 33847028789 scopus 로고    scopus 로고
    • BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin
    • Pageau G.J., Hall L.L., Lawrence J.B. BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin. Journal of Cellular Biochemistry 2007, 100:835-850.
    • (2007) Journal of Cellular Biochemistry , vol.100 , pp. 835-850
    • Pageau, G.J.1    Hall, L.L.2    Lawrence, J.B.3
  • 62
    • 65949099333 scopus 로고    scopus 로고
    • Misbehaviour of XIST RNA in breast cancer cells
    • Sirchia S., Tabano S., Monti L., Recalcati M. Misbehaviour of XIST RNA in breast cancer cells. PLoS One 2009, 4(5):e5559.
    • (2009) PLoS One , vol.4 , Issue.5
    • Sirchia, S.1    Tabano, S.2    Monti, L.3    Recalcati, M.4
  • 64
    • 18744372123 scopus 로고    scopus 로고
    • BRCA1 supports XIST RNA concentration on the inactive X chromosome
    • Ganesan S., Silver D.P., Greenberg R.A., Avni D., Drapkin R., Miron A., et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 2002, 111:393-405.
    • (2002) Cell , vol.111 , pp. 393-405
    • Ganesan, S.1    Silver, D.P.2    Greenberg, R.A.3    Avni, D.4    Drapkin, R.5    Miron, A.6
  • 65
    • 33749023326 scopus 로고    scopus 로고
    • The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability
    • Gudmundsdottir K., Ashworth A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene 2006, 25:5864-5874.
    • (2006) Oncogene , vol.25 , pp. 5864-5874
    • Gudmundsdottir, K.1    Ashworth, A.2
  • 66
    • 33749000596 scopus 로고    scopus 로고
    • The role of BRCA1 in transcriptional regulation and cell cycle control
    • Mullan P.B., Quinn J.E., Harkin D.P. The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene 2006, 25:5854-5863.
    • (2006) Oncogene , vol.25 , pp. 5854-5863
    • Mullan, P.B.1    Quinn, J.E.2    Harkin, D.P.3
  • 68
    • 0842281498 scopus 로고    scopus 로고
    • Aurora kinases link chromosome segregation and cell division to cancer susceptibility
    • Meraldi P., Honda R., Nigg E. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Current Opinion in Genetics and Development 2004, 14:29-36.
    • (2004) Current Opinion in Genetics and Development , vol.14 , pp. 29-36
    • Meraldi, P.1    Honda, R.2    Nigg, E.3
  • 69
    • 69449101751 scopus 로고    scopus 로고
    • AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome
    • Hall L.L., Byron M., Pageau G., Lawrence J.B. AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. The Journal of Cell Biology 2009, 186:491-507.
    • (2009) The Journal of Cell Biology , vol.186 , pp. 491-507
    • Hall, L.L.1    Byron, M.2    Pageau, G.3    Lawrence, J.B.4
  • 71
    • 33847388531 scopus 로고    scopus 로고
    • The XIST noncoding RNA functions independently of BRCA1 in X inactivation
    • Xiao C., Sharp J., Kawahara M., Davalos A. The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell 2007, 128:977-989.
    • (2007) Cell , vol.128 , pp. 977-989
    • Xiao, C.1    Sharp, J.2    Kawahara, M.3    Davalos, A.4
  • 72
    • 33845286542 scopus 로고    scopus 로고
    • BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin
    • Pageau G.J., Lawrence J.B. BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Journal of Cell Biology 2006, 175:693-701.
    • (2006) Journal of Cell Biology , vol.175 , pp. 693-701
    • Pageau, G.J.1    Lawrence, J.B.2
  • 75
    • 80052567822 scopus 로고    scopus 로고
    • BRCA1 tumour suppression occurs via heterochromatin-mediated silencing
    • Zhu Q., Pao G.M., Huynh A.M., Suh H., Tonnu N., Nederlof P.M., et al. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature 2011, 477:179-184.
    • (2011) Nature , vol.477 , pp. 179-184
    • Zhu, Q.1    Pao, G.M.2    Huynh, A.M.3    Suh, H.4    Tonnu, N.5    Nederlof, P.M.6
  • 76
  • 78
    • 84885483882 scopus 로고    scopus 로고
    • Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability
    • Slee R.B., Steiner C.M., Herbert B.-S., Vance G.H., Hickey R.J., Schwarz T., et al. Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability. Oncogene 2011, 1-10.
    • (2011) Oncogene , pp. 1-10
    • Slee, R.B.1    Steiner, C.M.2    Herbert, B.-S.3    Vance, G.H.4    Hickey, R.J.5    Schwarz, T.6
  • 79
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics 2009, 1:239-259.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 82
    • 83555173292 scopus 로고    scopus 로고
    • Satellite 2 demethylation induced by 5-azacytidine is associated with missegregation of chromosomes 1 and 16 in human somatic cells
    • Prada D., González R., Sánchez L., Castro C., Fabián E., Herrera L.A. Satellite 2 demethylation induced by 5-azacytidine is associated with missegregation of chromosomes 1 and 16 in human somatic cells. Mutation Research 2012, 729:100-105.
    • (2012) Mutation Research , vol.729 , pp. 100-105
    • Prada, D.1    González, R.2    Sánchez, L.3    Castro, C.4    Fabián, E.5    Herrera, L.A.6
  • 83
    • 0033435205 scopus 로고    scopus 로고
    • The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    • Hansen R.S. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proceedings of the National Academy of Sciences 1999, 96:14412-14417.
    • (1999) Proceedings of the National Academy of Sciences , vol.96 , pp. 14412-14417
    • Hansen, R.S.1
  • 84
    • 21744451159 scopus 로고    scopus 로고
    • Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements
    • Barki-Celli L., Lefebvre C., Le Baccon P., Nadeau G., Bonnefoix T., Usson Y., et al. Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. Genes, Chromosomes and Cancer 2005, 43:339-349.
    • (2005) Genes, Chromosomes and Cancer , vol.43 , pp. 339-349
    • Barki-Celli, L.1    Lefebvre, C.2    Le Baccon, P.3    Nadeau, G.4    Bonnefoix, T.5    Usson, Y.6
  • 85
    • 0029042985 scopus 로고
    • Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors
    • Pandis N., Teixeira M.R., Gerdes A.M., Limon J., Bardi G., Andersen J.A., et al. Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors. Cancer 1995, 76:250-258.
    • (1995) Cancer , vol.76 , pp. 250-258
    • Pandis, N.1    Teixeira, M.R.2    Gerdes, A.M.3    Limon, J.4    Bardi, G.5    Andersen, J.A.6
  • 86
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms
    • Mertens F., Johansson B., Höglund M., Mitelman F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Research 1997, 57:2765-2780.
    • (1997) Cancer Research , vol.57 , pp. 2765-2780
    • Mertens, F.1    Johansson, B.2    Höglund, M.3    Mitelman, F.4
  • 87
    • 79551642322 scopus 로고    scopus 로고
    • Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers
    • Ting D.T., Lipson D., Paul S., Brannigan B.W., Akhavanfard S., Coffman E.J., et al. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 2011, 331:593-596.
    • (2011) Science , vol.331 , pp. 593-596
    • Ting, D.T.1    Lipson, D.2    Paul, S.3    Brannigan, B.W.4    Akhavanfard, S.5    Coffman, E.J.6
  • 88
    • 71049188001 scopus 로고    scopus 로고
    • A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells
    • Eymery A., Horard B., Atifi-Borel El M., Fourel G., Berger F., Vitte A.-L., et al. A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells. Nucleic Acids Research 2009, 37:6340-6354.
    • (2009) Nucleic Acids Research , vol.37 , pp. 6340-6354
    • Eymery, A.1    Horard, B.2    Atifi-Borel El, M.3    Fourel, G.4    Berger, F.5    Vitte, A.-L.6
  • 92
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg A.P., Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301:89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 94
    • 0014407722 scopus 로고
    • Repeated Sequences in DNA
    • Britten R., Kohne D. Repeated Sequences in DNA. Science 1968, 161:529-540.
    • (1968) Science , vol.161 , pp. 529-540
    • Britten, R.1    Kohne, D.2
  • 95
    • 78049232764 scopus 로고    scopus 로고
    • Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus
    • Easwaran H.P., Van Neste L., Cope L., Sen S., Mohammad H.P., Pageau G.J., et al. Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. Cancer Research 2010, 70:8015-8024.
    • (2010) Cancer Research , vol.70 , pp. 8015-8024
    • Easwaran, H.P.1    Van Neste, L.2    Cope, L.3    Sen, S.4    Mohammad, H.P.5    Pageau, G.J.6
  • 98
    • 34047174594 scopus 로고    scopus 로고
    • Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress
    • Spencer V.A., Xu R., Bissell M.J. Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress. Advances in Cancer Research 2007, 275-294.
    • (2007) Advances in Cancer Research , pp. 275-294
    • Spencer, V.A.1    Xu, R.2    Bissell, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.