Cerebral hypoperfusion modifies the respiratory chemoreflex during orthostatic stress

Clinical Science

Volumn 125, Issue 1, 2013, Pages 37-44

  Ogoh, Shigehiko ^a   Nakahara, Hidehiro ^b   Okazaki, Kazunobu ^c   Bailey, Damian M ^d   Miyamoto, Tadayoshi ^b,e  

^a TOYO UNIVERSITY   (Japan)

^b MORINOMIYA UNIVERSITY OF MEDICAL SCIENCES   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF GLAMORGAN   (United Kingdom)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Arterial blood pressure; End tidal CO2; Lower Body Negative Pressure (LBNP); Middle cerebral artery blood velocity

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN PERFUSION; CHEMORECEPTOR REFLEX; HUMAN; HUMAN EXPERIMENT; LOWER BODY NEGATIVE PRESSURE; LUNG VENTILATION; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; ORTHOSTATIC STRESS; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SENSITIVITY ANALYSIS;

ADULT; BLOOD FLOW VELOCITY; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; HUMANS; LOWER BODY NEGATIVE PRESSURE; MALE; MIDDLE CEREBRAL ARTERY; ORTHOSTATIC INTOLERANCE; PULMONARY VENTILATION; STRESS, PHYSIOLOGICAL; SUPINE POSITION; YOUNG ADULT;

EID: 84875610981     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120335     Document Type: Article

References (41)

1. 2 differences and on alveolar dead space in man. Acta Physiol. Scand. 54, 65-82
2. 2. Eur. J. Appl. Physiol. 96, 609-614
3. Krishnamurthy, S., Wang, X., Bhakta, D., Bruce, E., Evans, J., Justice, T. and Patwardhan, A. (2004) Dynamic cardiorespiratory interaction during head-up tilt-mediated presyncope. Am. J. Physiol. Heart Circ. Physiol. 287, H2510-H2517
4. van Lieshout, J. J., Pott, F., Madsen, P. L., van Goudoever, J. and Secher, N. H. (2001) Muscle tensing during standing: effects on cerebral tissue oxygenation and cerebral artery blood velocity. Stroke 32, 1546-1551
5. Bode, H. (1991) Cerebral blood flow velocities during orthostasis and physical exercise. Eur. J. Pediatr. 150, 738-743
6. Madsen, P., Lyck, F., Pedersen, M., Olesen, H. L., Nielsen, H. and Secher, N. H. (1995) Brain and muscle oxygen saturation during head-up-tilt-induced central hypovolaemia in humans. Clin. Physiol. 15, 523-533
7. Scheinberg, P. and Stead, E. A. (1949) The cerebral blood flow in male subjects as measured by the nitrous oxide technique. Normal values for blood flow, oxygen utilization, glucose utilization, and peripheral resistance, with observations on the effect of tilting and anxiety. J. Clin. Invest. 28, 1163-1171
8. Markwalder, T. M., Grolimund, P., Seiler, R. W., Roth, F. and Aaslid, R. (1984) Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure-a transcranial ultrasound Doppler study. J. Cereb. Blood Flow Metab. 4, 368-372
9. Ogoh, S., Hayashi, N., Inagaki, M., Ainslie, P. N. and Miyamoto, T. (2008) Interaction between the ventilatory and cerebrovascular responses to hypo-and hypercapnia at rest and during exercise. J. Physiol. 586, 4327-4338
10. 2 changes induced by head-upright tilt on transcranial Doppler recordings. Stroke 28, 1195-1197
11. 2 on dynamic cerebral autoregulation measurement. Physiol. Meas. 20, 265-275
12. 2 increases orthostatic tolerance during repeated tilt. Aviat. Space Environ. Med. 72, 985-991
13. 2. Am J. Physiol. Regul. Integr. Comp. Physiol. 290, R1087-R1093
14. Bernardi, L., Casucci, G., Haider, T., Brandstatter, E., Pocecco, E., Ehrenbourg, I. and Burtscher, M. (2008) Autonomic and cerebrovascular abnormalities in mild COPD are worsened by chronic smoking. Eur. Respir. J. 32, 1458-1465
15. Reichmuth, K. J., Dopp, J. M., Barczi, S. R., Skatrud, J. B., Wojdyla, P., Hayes, Jr, D. and Morgan, B. J. (2009) Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment. Am. J. Respir. Crit. Care Med. 180, 1143-1150
16. Yaggi, H. K., Concato, J., Kernan, W. N., Lichtman, J. H., Brass, L. M. and Mohsenin, V. (2005) Obstructive sleep apnea as a risk factor for stroke and death. N. Engl. J. Med. 353, 2034-2041
17. 2. J. Physiol. 584, 347-357
18. Xie, A., Skatrud, J. B., Khayat, R., Dempsey, J. A., Morgan, B. and Russell, D. (2005) Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am. J. Respir. Crit. Care Med. 172, 371-378
19. Xie, A., Skatrud, J. B., Morgan, B., Chenuel, B., Khayat, R., Reichmuth, K., Lin, J. and Dempsey, J. A. (2006) Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J. Physiol. 577, 319-329
20. Ogoh, S., Volianitis, S., Nissen, P., Wray, D. W., Secher, N. H. and Raven, P. B. (2003) Carotid baroreflex responsiveness to head-up tilt-induced central hypovolaemia: effect of aerobic fitness. J. Physiol. 551, 601-608
21. Fitzgerald, R. S. and Parks, D. C. (1971) Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. Respir. Physiol. 12, 218-229
22. Poon, C. S. and Greene, J. G. (1985) Control of exercise hyperpnea during hypercapnia in humans. J. Appl. Physiol. 59, 792-797
23. Miyamoto, T., Inagaki, M., Takaki, H., Kawada, T., Yanagiya, Y., Sugimachi, M. and Sunagawa, K. (2004) Integrated characterization of the human chemoreflex system controlling ventilation, using an equilibrium diagram. Eur. J. Appl. Physiol. 93, 340-346
24. 2 reactivity during strenuous exercise in man. Eur. J. Appl. Physiol. 96, 299-304
25. Levine, B. D., Giller, C. A., Lane, L. D., Buckey, J. C. and Blomqvist, C. G. (1994) Cerebral versus systemic hemodynamics during graded orthostatic stress in humans. Circulation 90, 298-306
26. Schondorf, R., Stein, R., Roberts, R., Benoit, J. and Cupples, W. (2001) Dynamic cerebral autoregulation is preserved in neurally mediated syncope. J. Appl. Physiol. 91, 2493-2502
27. Ogoh, S., Brothers, R. M., Barnes, Q., Eubank, W. L., Hawkins, M. N., Purkayastha, S., A, O. Y. and Raven, P. B. (2005) The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J. Physiol. 569, 697-704
28. Harms, M. P., Wesseling, K. H., Pott, F., Jenstrup, M., Van Goudoever, J., Secher, N. H. and Van Lieshout, J. J. (1999) Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin. Sci. 97, 291-301
29. Bolser, D. C., Lindsey, B. G. and Shannon, R. (1988) Respiratory pattern changes produced by intercostal muscle/rib vibration. J. Appl. Physiol. 64, 2458-2462
30. Riley, R. L., Permutt, S., Said, S., Godfrey, M., Cheng, T. O., Howell, J. B. and Shepard, R. H. (1959) Effect of posture on pulmonary dead space in man. J. Appl. Physiol. 14, 339-344
31. Ogoh, S. and Ainslie, P. N. (2009) Cerebral blood flow during exercise: mechanisms of regulation. J. Appl. Physiol. 107, 1370-1380
32. Chapman, R. W., Santiago, T. V. and Edelman, N. H. (1979) Effects of graded reduction of brain blood flow on chemical control of breathing. J. Appl. Physiol. 47, 1289-1294
33. Dempsey, J. A. (2005) Crossing the apnoeic threshold: causes and consequences. Exp. Physiol. 90, 13-24
34. Ogoh, S., Ainslie, P. N. and Miyamoto, T. (2009) Onset responses of ventilation and cerebral blood flow to hypercapnia in humans: rest and exercise. J. Appl. Physiol. 106, 880-886
35. Cannizzaro, G., Garbin, L., Clivati, A. and Pesce, L. I. (1997) Correction of hypoxia and hypercapnia in COPD patients: effects on cerebrovascular flow. Monaldi Arch. Chest Dis. 52, 9-12
36. Andreas, S., Anker, S. D., Scanlon, P. D. and Somers, V. K. (2005) Neurohumoral activation as a link to systemic manifestations of chronic lung disease. Chest 128, 3618-3624
37. Liesker, J. J., Postma, D. S., Beukema, R. J., ten Hacken, N. H., van der Molen, T., Riemersma, R. A., van Zomeren, E. H. and Kerstjens, H. A. (2004) Cognitive performance in patients with COPD. Respir. Med. 98, 351-356
38. Ogoh, S., Fadel, P. J., Zhang, R., Selmer, C., Jans, O., Secher, N. H. and Raven, P. B. (2005) Middle cerebral artery flow velocity and pulse pressure during dynamic exercise in humans. Am. J. Physiol. Heart Circ. Physiol. 288, H1526-H1531
39. Serrador, J. M., Picot, P. A., Rutt, B. K., Shoemaker, J. K. and Bondar, R. L. (2000) MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678
40. Sato, K., Fisher, J. P., Seifert, T., Overgaard, M., Secher, N. H. and Ogoh, S. (2012) Blood flow in internal carotid and vertebral arteries during orthostatic stress. Exp. Physiol. 97, 1272-1280
41. 2 in human internal and external carotid and vertebral arteries. J. Physiol. 590, 3277-3290