Heterogeneity in viral shedding among individuals with medically attended influenza a virus infection

Journal of Infectious Diseases

Volumn 207, Issue 8, 2013, Pages 1281-1285

  Lau, Lincoln L H ^a   Ip, Dennis K M ^a   Nishiura, Hiroshi ^a,d   Fang, Vicky J ^a   Chan, Kwok Hung ^b   Peiris, J S Malik ^a,c   Leung, Gabriel M ^a   Cowling, Benjamin J ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Department of Microbiology ^*  (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

infectiousness; influenza; viral shedding

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; CONTROLLED STUDY; DENATURATION; FEMALE; GENETIC HETEROGENEITY; HUMAN; INFLUENZA A; INFLUENZA A (H3N2); LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEASONAL INFLUENZA; VIRUS SHEDDING; VIRUS TRANSMISSION;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; DNA, COMPLEMENTARY; FEMALE; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; LINEAR MODELS; MALE; MODELS, BIOLOGICAL; RNA, VIRAL; SEASONS; TIME FACTORS; VIRUS SHEDDING; YOUNG ADULT;

EID: 84875601955     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit034     Document Type: Article

References (15)

1. Stein RA. Super-spreaders in infectious diseases. Int J Infect Dis 2011; 15:e510-3.
2. Cori A, Boelle PY, Thomas G, Leung GM, Valleron AJ. Temporal variability and social heterogeneity in disease transmission: the case of SARS in Hong Kong. PLoS Comput Biol 2009; 5: e1000471.
3. Moser MR, Bender TR, Margolis HS, Noble GR, Kendal AP, Ritter DG. An outbreak of influenza aboard a commercial airliner. Am J Epidemiol 1979; 110:1-6.
4. Pestre V, Morel B, Encrenaz N, et al. Transmission by super-spreading event of pandemic A/H1N1 2009 influenza during road and train travel. Scand J Infect Dis 2012; 44:225-7.
5. Lloyd-Smith JO, Schreiber SJ, Kopp PE, Getz WM. Superspreading and the effect of individual variation on disease emergence. Nature 2005; 438:355-9.
6. Bell DM. Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg Infect Dis 2006; 12:81-7.
7. Lau LL, Cowling BJ, Fang VJ, et al. Viral shedding and clinical illness in naturally acquired influenza virus infections. J Infect Dis 2010; 201:1509-16.
8. Carrat F, Vergu E, Ferguson NM, et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 2008; 167:775-85.
9. Loeb M, Singh PK, Fox J, et al. Longitudinal study of influenza molecular viral shedding in Hutterite communities. J Infect Dis 2012; 206:1078-84.
10. Cowling BJ, Chan KH, Fang VJ, et al. Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial. Ann Intern Med 2009; 151:437-46.
11. Cowling BJ, Chan KH, Fang VJ, et al. Comparative epidemiology of pandemic and seasonal influenza A in households. N Engl J Med 2010; 362:2175-84.
12. Peiris JS, Tang WH, Chan KH, et al. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 2003; 9:628-33.
13. Ip DK, Schutten M, Fang VJ, et al. Validation of self-swab for virologic confirmation of influenza virus infections in a community setting. J Infect Dis 2012; 205:631-4.
14. Monto AS. Epidemiology of viral respiratory infections. Am J Med 2002; 112(Suppl 6A):4S-12.
15. Woolhouse ME, Dye C, Etard JF, et al. Heterogeneities in the transmission of infectious agents: implications for the design of control programs. Proc Natl Acad Sci U S A 1997; 94:338-42.