Severe hypertriglyceridaemia in Type 2 diabetes mellitus: Beneficial effect of continuous insulin infusion

QJM: An International Journal of Medicine

Volumn 106, Issue 4, 2013, Pages 355-359

  Henderson, S R ^a   Maitland, R ^a   Mustafa, O G ^a   Miell, J ^a   Crook, M A ^a   Kottegoda, S R ^a  

^a UNIVERSITY HOSPITAL LEWISHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; ENOXAPARIN; FIBRIC ACID DERIVATIVE; HEPARIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; OMEGA 3 ACID ETHYL ESTER; ORAL ANTIDIABETIC AGENT; TRIACYLGLYCEROL;

ADULT; AGED; AMYLASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DIABETIC PATIENT; DISEASE ASSOCIATION; FEMALE; GLYCEMIC CONTROL; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INSULIN INFUSION; MALE; MEDICAL RECORD REVIEW; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84875589759     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcs238     Document Type: Article

References (20)

1. Anderson F, Thomson SR, Clarke DL, Buccimazza I. Dyslipidaemic pancreatitis clinical assessment and analysis of disease severity and outcomes. Pancreatology 2009; 9:252-7.
2. Chang CC, Hsieh YY, Tsai HD, Yang TC, Yeh LS, Hsu TY. Acute pancreatitis in pregnancy. Zhonghua Yi Xue Za Zhi 1998; 61:85-92.
3. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridaemia as a cardiovascular risk factor. Am J Cardiol 1998; 81:7-128.
4. Ferns G, Keti V, Griffin B. Investigation and management of hypertriglyceridaemia. J Clin Pathol 2008; 61:1174-83.
5. Picard F, Boivin A, Lalonde J, Deshaies Y. Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Am J Physiol Endocrinol Metab 2002; 282:E412-8.
6. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002; 23:201-29.
7. Pollex RL, Hegele RA. Genetic determinants of the metabolic syndrome. Nat Clin Pract Cardiovasc Med 2006; 3:482-9.
8. Triay JM, Day A, Signhai P. Safe and rapid resolution of severe hypertriglyceridaemia in two patients with intravenous insulin. Diabet Med 2010; 27:1080-3.
9. Henzen C, Rock M, Schnieper C, Heer K. Heparin and insulin in the treatment of acute hypertriglyceridaemia-induced pancreatitis. Schweiz Med Wochenschr 1999; 129:1242-8.
10. Berger ZF, Quera RP, Poniachik JT, Oksenberg DR, Guerrero JP. Heparin and/or insulin treatment of acute pancreatitis caused by hypertriglyceridemia. Experience of 5 cases. Rev Med Chil 2001; 129:1373-8.
11. Falissard B, Mauri M, Shaw K, Wetterling T, Doble A, Giudicelli A, et al. The METEOR study: frequency of metabolic disorders in patients with schizophrenia. Focus on first and second generation and level of risk of antipsychotic drugs. Int Clin Psychopharmacol 2011; 26:291-302.
12. Sharma P, Lim S, James D, Orchard RT, Horne M, Seymour CA. Pancreatitis may occur with a normal amylase concentration in hypertriglyceridaemia. BMJ 1996; 313:1265.
13. Korn ED. Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterisation of the enzyme from normal rat heart. J Biol Chem 1955; 215:1-14.
14. Sadur CN, Eckel RH. Insulin stimulation of adipose tissue lipoprotein lipase. Use of the euglycemic clamp technique. J Clin Invest 1982; 69:1119-25.
15. Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006; 116:2464-72.
16. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Hass JT, Aleman JO, Suzuki R, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008; 7:125-34.
17. Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 2000; 6:77-86.
18. Mikhail N, Trivedi K, Page C, Wali S, Cope D. Treatment of severe hypertriglycerideaemia in non-diabetic patients with insulin. Am J Emerg Med 2005; 23:415-7.
19. Jabbar MA, Zuhri-Yafi MI, Larrea J. Insulin therapy for a non-diabetic patient with severe hypertriglyceridaemia. J Am Coll Nutr 1998; 17:458-61.
20. Tamez-Pérez HE, Sáenz-Gallegos R, Hernández-Rodríguez K, Forsbach-Sánchez G, Gómez-de Ossio MD, Fernández-Garza N, et al. Insulin therapy in patients with severe hypertriglyceridemia. Rev Med Inst Mex Seguro Soc 2006; 44:235-7.