Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses

CNS Neuroscience and Therapeutics

Volumn 19, Issue 4, 2013, Pages 235-243

  Xu, Min Xuan ^a   Tan, Bing Chang ^a,b   Zhou, Wei ^c   Wei, Ting ^d   Lai, Wei Hong ^e   Tan, Jing Wang ^a   Dong, Jia Hong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b GUIZHOU UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

^d SOUTHEAST UNIVERSITY   (China)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Lipopolysaccharide; Microglial cells; Nerve inflammation; Phosphorylation; Resolvin D1

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; RESOLVIN D1; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CELL VIABILITY; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; CYTOPLASM; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; IMMUNOFLUORESCENCE; IN VITRO STUDY; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; DOCOSAHEXAENOIC ACIDS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84875583318     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12069     Document Type: Article

References (20)

1. Xu ZZ, Berta T, Ji RR. Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. J Neuroimmune Pharmacol DOI: 10.1007/s11481-012-9394-8.
2. Amor S, Puentes F, Baker D, Valk P. Inflammation in neurodegenerative diseases. Immunology 2010;129:154-169.
3. Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat Rev Neurosci 2007;8:57-69.
4. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: A maladaptive response of the nervous system to damage. Annu Rev Neurosci 2009;32:1-32.
5. Polazzi E, Contestabile A. Reciprocal interactions between microglia and neurons: From survival to neuropathology. Rev Neurosci 2002;13:221-242.
6. Streit WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL. Role of microglia in the central nervous system's immune response. Neurol Res 2005;27:685-691.
7. Lull ME, Block ML. Microglial activation and chronic neurodegeneration. Neurotherapeutics 2010;7:354-365.
8. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008;8:349-361.
9. Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog Neurobiol 2005;76:77-98.
10. Connor KM, SanGiovanni JP, Lofqvist C, et al. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 2007;13:868-873.
11. Serhan CN, Hong S, Gronert K, et al. Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 2002;196:1025-1037.
12. Sun YP, Oh SF, Uddin J, et al. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 2007;282:9323-9334.
13. Jin YP, Arita M, Zhang Q, et al. Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Ophthalmol Vis Sci 2009;50:4743-4752.
14. Krishnamoorthya S, Recchiutia A, Chianga N, et al. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. PNAS 2010;107:1660-1665.
15. Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN. Aspirin triggered 15-epilipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors. J Exp Med 1997;185:1693-1704.
16. Chiang N, Takano T, Arita M, Watanabe S, Serhan CN. A novel rat lipoxin A4 receptor that is conserved in structure and function. Br J Pharmacol 2003;139:89-98.
17. Fiore S, Maddox JF, Perez HD, Serhan CN. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med 1994;180:253-260.
18. Vaughn MW, Proske RJ, Haviland DL. Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. J Immunol 2002;169:3363-3369.
19. Gulian D, Baker TJ. Characterization of amoeboid microglia isolated from developing mammalian brain. J Neurosci 1986;6:2163-2178.
20. McCarthy KD, Devellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980;85:890-902.