Design and Synthesis of (R)-1-Arylsulfonylpiperidine-2-carboxamides as 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors

ChemMedChem

Volumn 8, Issue 4, 2013, Pages 577-581

  Xia, Guangxin ^a,b   Liu, Lin ^a,b   Liu, Haiyan ^a   Yu, Jianxin ^a   Xu, Zhenmin ^a   Chen, Qian ^a   Ma, Chen ^a   Li, Ping ^a   Xiong, Bing ^b   Liu, Xuejun ^a   Shen, Jingkang ^a,b  

^a Central Research Institute   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

11 HSD1; Diabetes; Docking; Inhibitors

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; AMIDE; ENZYME INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AMIDES; ANIMALS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HALF-LIFE; HUMANS; ISOMERISM; MICE; MOLECULAR DOCKING SIMULATION; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875579062     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300022     Document Type: Article

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