Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 13, 2013, Pages 5103-5108

  Siddle, Hannah V ^a   Kreiss, Alexandre ^b   Tovar, Cesar ^b   Yuen, Chun Kit ^a   Cheng, Yuanyuan ^c   Belov, Katherine ^c   Swift, Kate ^d   Pearse, Anne Maree ^d   Hamede, Rodrigo ^e   Jones, Menna E ^e   Skjødt, Karsten ^f   Woods, Gregory M ^b   Kaufman, Jim ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF TASMANIA   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d DEPARTMENT OF PRIMARY INDUSTRIES   (Australia)

^e UNIVERSITY OF TASMANIA   (Australia)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Canine transmissible venereal tumor; Immune evasion; Primary tumour; Transplantation

Indexed keywords

BETA 2 MICROGLOBULIN; HISTONE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT GAMMA INTERFERON;

ALLOGRAFT; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CANCER MORTALITY; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DEACETYLATION; DEVIL FACIAL TUMOR DISEASE; DOWN REGULATION; ENZYME ACTIVITY; EPIGENETICS; ESSENTIAL GENE; FACE TUMOR; GENE EXPRESSION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STRUCTURAL GENE; TUMOR CELL; UPREGULATION;

ANIMALS; ANTIGEN PRESENTATION; CELL LINE, TUMOR; ENDANGERED SPECIES; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS; INTERFERON-GAMMA; MARSUPIALIA; SKIN NEOPLASMS; TUMOR ESCAPE;

SARCOPHILUS HARRISII;

EID: 84875518893     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219920110     Document Type: Article

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