Diabetes: Looking back at Look AHEAD - Giving lifestyle a chance

Nature Reviews Cardiology

Volumn 10, Issue 4, 2013, Pages 184-186

  Després, Jean Pierre ^a   Poirier, Paul ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE;

ARTICLE; BEVERAGE; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES EDUCATION; EXERCISE; GLYCEMIC CONTROL; HUMAN; LIFESTYLE MODIFICATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL VALUE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME; WEIGHT REDUCTION;

CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIET; EARLY TERMINATION OF CLINICAL TRIALS; EXERCISE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; RISK REDUCTION BEHAVIOR; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84875486810     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2013.16     Document Type: Article

References (10)

1. US Department of Health and Human Services. National Institutes of Health. Weight loss does not lower heart disease risk from type 2 diabetes [online], http://www.nih.gov/news/health/oct2012/niddk 19.htm (2012
2. Ryan, D. H. et al. Look AHEAD (Action for Health in Diabetes): Design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control. Clin. Trials 24, 610-628 (2003
3. Pi-Sunyer, X. et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: One-year results of the look AHEAD trial. Diabetes Care 30, 1374-1383 (2007
4. Wadden, T. A. et al. Four-year weight losses in the Look AHEAD study: Factors associated with long-Term success. Obesity (Silver Spring) 19, 1987-1998 (2011
5. Brancati, F. L. et al. Midcourse correction to a clinical trial when the event rate is underestimated: The Look AHEAD (Action for Health in Diabetes) Study. Clin. Trials 9, 113-124 (2012
6. Das, P. & Horton, R. Rethinking our approach to physical activity. Lancet 380, 189-190 (2012
7. Mozaffarian, D. Achieving cardiovascular health: A bleak outlook or tremendous potential? J. Am. Coll. Cardiol. 57, 1697-1699 (2011
8. Tuomilehto, J. Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes. Diabetes Care 32 (Suppl. 2), S189-S193 (2009
9. Gregg, E. W. et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA 308, 2489-2496 (2012
10. Unger, R. H., Clark, G. O., Scherer, P. E. & Orci, L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim. Biophys. Acta 1801, 209-214 (2010