Antihyperglycemic effect of different solvent extracts of leaves of Cajanuscajan and HPLC profile of the active extracts

Asian Journal of Pharmaceutical and Clinical Research

Volumn 5, Issue 2, 2012, Pages 123-126

  Dolui, A K ^a   Sengupta, Rupa ^a  

^a DIBRUGARH UNIVERSITY   (India)

Author keywords

Acute toxicity; Alloxan; Antihyperglycemic activity; Cajanus cajan

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIDIABETIC AGENT; CAJANUS CAJAN EXTRACT; CHLOROFORM; GLIBENCLAMIDE; GLUCOSE; INSULIN; METHANOL; PETROLEUM ETHER; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENTIATION; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONOTHERAPY; MOUSE; NONHUMAN; PIGEONPEA; PLANT LEAF; TOXICITY TESTING;

EID: 84875479809     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Kameswarrao B, Giri R, Kesavalu MM, Approach.: Herbal medicine; in the management of diabetes mellitus. Manphar Vaidhya patrika1997; 1(4), 33-35.
2. th Ed.1996; 1487-1518.
3. Kade IJ, Barbosa NBV, Ibukun EO, Igbakin AP, Nogueira CW, Rocha JBT, Aqueous extracts of Sphagneticola trilobata attenuates streptozotocin-induced hyperglycaemia in rat models by modulating oxidative stress parameters. Biology and Medicine 2010; 2 (3): 1-13.
4. Kalarani H D, Dinakar A, Kumar S N, Hypoglycemic and antidiabetic activity of Alangium salvifolium wang in alloxan induced diabetic rats, Asian Journal of Pharmaceutical and Clinical Research 2011;4(1):131-133.
5. Satyanarayana T, Katyayani BM, Latha HE, et al: Phcog. Mag 2006; 2, 244.
6. nd Ed.1981; 809-811.
7. Kanjilal, UN, and Das PC, Flora of Assam, Printed at Jay Offset Press, Delhi-6. Vol. II, 1982;97-98.
8. Abbiw DK. Useful Plants of Ghana; Richmond Intermediate Technology Publications and Royal Botanic Gardens: Kew, London, UK, 1990.
9. Duke JA, Vasquez R. Amazonian Ethnobotanical Dictionary; CRC Press: Boca Raton, FL, USA, 1994.
10. Amalraj T, Ignacimuthu S. Evaluation of the hypoglycaemic effect of Cajanus cajan (seeds) in mice. Indian J. Exp. Biol 1998;36: 1032-1033.
11. Grover JK, Yadav S, Vats VJ. Medicinal plants of India with antidiabetic potential. J. Ethnopharmacol 2002;81: 81-100
12. Tang Y, Wang B, Zhou X.J. Effect of external application of herbal cajani preparation on the fibronection content during healing process of open wound. J. Guangzhou U. Tradit. Chin. Med 1999; 1: 302-304.
13. Chen DSH, Li HY, Lin H. Studies on chemical constituents in pigeonpea leaves. Chin. Tradit. Herb Drugs 1985; 16: 134-136.
14. Li ZH, Zhou CH, Gu Y et al. The present status of study and utilization of pigeon pea in China and its prospects. Forest Res 2001; 14: 674-681.
15. Luo, QF, Sun, L, Si, JY et al. Hypocholesterolemic effect of stilbenes containing extract-fraction from Cajanus cajan L. on diet-induced hypercholesterolemia in mice. Phytomedicine 2008;15: 932-939.
16. Huang G. Y, Liao X. Z, Liao H. F et al Studies on water-soluble extracts from Cajanus cajan leaf against hypoxic-ischemic brain damage. Tradit. Chin. Drug Res Clin. Pharmacol 2006;17: 172-174.
17. Kundu R, Dasgupta S, Biswas A et al. Cajanus cajan Linn. (Leguminosae) prevents alcohol-inducedrat liver damage and augments cytoprotective function. J. Ethnopharmacol 2008;118: 440-447.
18. Wu N, Fu K, Fu YJ et al. Antioxidant activities of extracts and main components of Pigeon pea [Cajanus cajan (L.) Millsp.] leaves. Molecules 2009;14: 1032-1043.
19. Ecobichon D.J., The basis of Toxicology Testing, RC Press, New York.1997;43-86.
20. S. Bhevna, B. Chandrajeet and R. Partha, Food Chem. Toxicol. 2008;46:2376.
21. Ghosh S, Suryawanshi SA. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Ind J Exp Biol 2001; 39: 748-759.
22. Kale SR, Kale RR. Practical human anatomy and physiology, Nirali Prakashan, 1993; 5-8.
23. Rerup C. C, Drugs produceing Diabetes through insulin secreating cells. Pharmacological Reviews 1970;22:480-520.
24. Chattopadhyay S, Ramanathan M, Das J, Bhattacharya SK, Animal models in experimental diabetes mellitus. Indian Journal of Experimental Biology 1997;35: 1141-1145.
25. Yollr RS, Black H, Villajam M, Berson SA, Comparison of phase insulin levels following administration of tolbutamide and glucose. Diabetes 1960;9:356-362.
26. Grozsky G. M, Epstein G. H, Fanska R, Karan JH, Pancreatic action of Sulphonylureas. Fedaration Procedings 1971:36:2719-2728.
27. Rajendran K, Shirwaikar A, Srinivasan K K, Preliminary anti-diabetic studies on aqueous root extract of pseudarthria viscida linn., Asian Journal of Pharmaceutical and ClinicalResearch 2011; 4(1):56-58.