-
1
-
-
0035998265
-
Rapid internal acyl migration and protein binding of synthetic probenecid glucuronides
-
Akira K , Uchijima T , Hashimoto T . 2002 . Rapid internal acyl migration and protein binding of synthetic probenecid glucuronides . Chem Res Toxicol 15 : 765 - 772 .
-
(2002)
Chem Res Toxicol
, vol.15
, pp. 765-772
-
-
Akira, K.1
Uchijima, T.2
Hashimoto, T.3
-
3
-
-
33845996187
-
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
-
Barter ZE , Bayliss MK , Beaune PH , Boobis AR , Carlile DJ , Edwards RJ , Houston JB , Lake BG , Lipscomb JC , Pelkonen OR , Tucker GT , Rostami - Hodjegan A. 2007 . Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver . Curr Drug Metab 8 : 33 - 45 .
-
(2007)
Curr Drug Metab
, vol.8
, pp. 33-45
-
-
Barter, Z.E.1
Bayliss, M.K.2
Beaune, P.H.3
Boobis, A.R.4
Carlile, D.J.5
Edwards, R.J.6
Houston, J.B.7
Lake, B.G.8
Lipscomb, J.C.9
Pelkonen, O.R.10
Tucker, G.T.11
Rostami-Hodjegan, A.12
-
4
-
-
62249155473
-
Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction
-
Bauman JN , Kelly JM , Tripathy S , Zhao SX , Lam WW , Kalgutkar AS , Obach RS . 2009 . Can in vitro metabolism - dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S - 9 fraction . Chem Res Toxicol 22 ( 2 ): 332 - 340 .
-
(2009)
Chem Res Toxicol
, vol.22
, Issue.2
, pp. 332-340
-
-
Bauman, J.N.1
Kelly, J.M.2
Tripathy, S.3
Zhao, S.X.4
Lam, W.W.5
Kalgutkar, A.S.6
Obach, R.S.7
-
5
-
-
0141569531
-
Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs
-
Beconi MG , Mao A , Liu DQ , Kochansky C , Pereira T , Raab C , Pearson P , Lee Chiu S - H. 2003 . Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs . Drug Metab Dispos 31 : 1269 - 1277 .
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1269-1277
-
-
Beconi, M.G.1
Mao, A.2
Liu, D.Q.3
Kochansky, C.4
Pereira, T.5
Raab, C.6
Pearson, P.7
Lee Chiu, S.-H.8
-
6
-
-
84888721648
-
-
Molybdenum hydroxylases Enzyme Systems That Metabolise Drugs and Other Xenobiotics ed. Ioannides C., 147-187 New York, Wiley
-
Beedham C. 2002 . Molybdenum hydroxylases . In Enzyme Systems That Metabolise Drugs and Other Xenobiotics , ed. Ioannides C , 147 - 187 . New York : Wiley .
-
(2002)
-
-
Beedham, C.1
-
7
-
-
0038722339
-
Ziprasidone metabolism, aldehyde oxidase, and clinical implications
-
Beedham C , Miceli JJ , Obach RS . 2003 . Ziprasidone metabolism, aldehyde oxidase, and clinical implications . J Clin Psychopharmacol 23 : 229 - 232 .
-
(2003)
J Clin Psychopharmacol
, vol.23
, pp. 229-232
-
-
Beedham, C.1
Miceli, J.J.2
Obach, R.S.3
-
8
-
-
71949106600
-
The drug transporter-metabolism alliance: Uncovering and defi ning the interplay
-
Benet LZ. 2009 . The drug transporter - metabolism alliance: Uncovering and defi ning the interplay . Mol Pharm 6 : 1631 - 1643 .
-
(2009)
Mol Pharm
, vol.6
, pp. 1631-1643
-
-
Benet, L.Z.1
-
9
-
-
0027199712
-
Predictability of the covalent binding of acidic drugs in man
-
Benet LZ , Spahn - Langguth H , Iwakawa S , Volland C , Mizuma T , Mayer S , Mutschler E , Lin ET.. 1993 . Predictability of the covalent binding of acidic drugs in man . Life Sci 53 : PL141 - PL146 .
-
(1993)
Life Sci
, vol.53
-
-
Benet, L.Z.1
Spahn-Langguth, H.2
Iwakawa, S.3
Volland, C.4
Mizuma, T.5
Mayer, S.6
Mutschler, E.7
Lin, E.T.8
-
10
-
-
10744232330
-
The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective
-
Bjornsson TD , Callaghan JT , Einolf HJ , Fischer V , Gan L , Grimm S , Kao J , King SP , Miwa G , Ni L , Kumar G , McLeod J , Obach RS , Roberts S , Roe A , Shah A , Snikeris F , Sullivan JT , Tweedie D , Vega JM , Walsh J , Wrighton SA. 2003a . The conduct of in vitro and in vivo drug - drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective . Drug Metab Dispos 31 : 815 - 832 .
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 815-832
-
-
Bjornsson, T.D.1
Callaghan, J.T.2
Einolf, H.J.3
Fischer, V.4
Gan, L.5
Grimm, S.6
Kao, J.7
King, S.P.8
Miwa, G.9
Ni, L.10
Kumar, G.11
McLeod, J.12
Obach, R.S.13
Roberts, S.14
Roe, A.15
Shah, A.16
Snikeris, F.17
Sullivan, J.T.18
Tweedie, D.19
Vega, J.M.20
Walsh, J.21
Wrighton, S.A.22
more..
-
11
-
-
0142131213
-
The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective
-
Bjornsson TD , Callaghan JT , Einolf HJ , Fischer V , Gan L , Grimm S , Kao J , King SP , Miwa G , Ni L , Kumar G , McLeod J , Obach SR , Roberts S , Roe A , Shah A , Snikeris F , Sullivan JT , Tweedie D , Vega JM , Walsh J , Wirghton SA. 2003b . The conduct of in vitro and in vivo drug - drug interaction studies: A PhRMA perspective . J Clin Pharmacol 43 : 443 - 469 .
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 443-469
-
-
Bjornsson, T.D.1
Callaghan, J.T.2
Einolf, H.J.3
Fischer, V.4
Gan, L.5
Grimm, S.6
Kao, J.7
King, S.P.8
Miwa, G.9
Ni, L.10
Kumar, G.11
McLeod, J.12
Obach, S.R.13
Roberts, S.14
Roe, A.15
Shah, A.16
Snikeris, F.17
Sullivan, J.T.18
Tweedie, D.19
Vega, J.M.20
Walsh, J.21
Wirghton, S.A.22
more..
-
12
-
-
0035996572
-
Xenobiotic acyl glucuronides and acyl CoA thioesters as protein -reactive metabolites with the potential to cause idiosyncratic drug reactions
-
Boelsterli UA. 2002 . Xenobiotic acyl glucuronides and acyl CoA thioesters as protein -reactive metabolites with the potential to cause idiosyncratic drug reactions . Curr Drug Metab 3 : 439 - 445 .
-
(2002)
Curr Drug Metab
, vol.3
, pp. 439-445
-
-
Boelsterli, U.A.1
-
13
-
-
0036206773
-
Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin
-
Bolze S , Bromet N , Gay - Feutry C , Massiere F , Boulieu R , Hulot T. 2002 . Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin . Drug Metab Dispos 30 : 404 - 413 .
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 404-413
-
-
Bolze, S.1
Bromet, N.2
Gay-Feutry, C.3
Massiere, F.4
Boulieu, R.5
Hulot, T.6
-
14
-
-
0018967595
-
Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazapines and phenytoin
-
Boxenbaum H. 1980 . Interspecies variation in liver weight, hepatic blood fl ow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazapines and phenytoin . J Pharmacokinet Biopharm 8 : 165 - 176 .
-
(1980)
J Pharmacokinet Biopharm
, vol.8
, pp. 165-176
-
-
Boxenbaum, H.1
-
16
-
-
0000234213
-
-
Handbook of Drug Metabolism ed. Woolf EJ., 477-505. New York: Marcel Dekker
-
Cashman J.. 1999 . In vitro metabolism: FMO and related oxygenations . In Handbook of Drug Metabolism , ed. Woolf EJ , 477 - 505. New York: Marcel Dekker .
-
(1999)
vitro metabolism: FMO and related oxygenations
-
-
Cashman, J.1
-
17
-
-
33144459248
-
Human fl avin-containing monooxygenases
-
Cashman JR , Zhang J . 2006 . Human fl avin - containing monooxygenases . Annu Rev Pharmacol Toxicol 46 : 65 - 100 .
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 65-100
-
-
Cashman, J.R.1
Zhang, J.2
-
18
-
-
67649404709
-
vitro and in vivo induction of cytochrome p450: A survey of the current practices and recommendations: A Pharmaceutical Research and Manufacturers of America perspective
-
Chu V , Einolf HJ , Evers R , Kumar G , Moore D , Ripp S , Silva J , Sinha V , Sinz M , Skerjanec A . 2009 . In vitro and in vivo induction of cytochrome p450: A survey of the current practices and recommendations: A Pharmaceutical Research and Manufacturers of America perspective . Drug Metab Dispos 37 : 1339 - 1354 .
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1339-1354
-
-
Chu, V.1
Einolf, H.J.2
Evers, R.3
Kumar, G.4
Moore, D.5
Ripp, S.6
Silva, J.7
Sinha, V.8
Sinz, M.9
Skerjanec, A.10
-
19
-
-
33645982578
-
Prediction of maximum exposure in poor metabolizers following inhibition of nonpolymorphic pathways
-
Collins C , Levy R , Ragueneau - Majlessi I , Hachad H. 2006 . Prediction of maximum exposure in poor metabolizers following inhibition of nonpolymorphic pathways . Curr Drug Metab 7 : 295 - 299 .
-
(2006)
Curr Drug Metab
, vol.7
, pp. 295-299
-
-
Collins, C.1
Levy, R.2
Ragueneau-Majlessi, I.3
Hachad, H.4
-
20
-
-
0025863054
-
The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland
-
Curran PG , DeGroot LJ.. 1991 . The effect of hepatic enzyme - inducing drugs on thyroid hormones and the thyroid gland . Endocr Rev 12 : 135 - 150 .
-
(1991)
Endocr Rev
, vol.12
, pp. 135-150
-
-
Curran, P.G.1
DeGroot, L.J.2
-
21
-
-
0032826052
-
Disposition and chemical stability of telmisartan 1- O- acylglucuronide
-
Ebner T , Heinzel G , Prox A , Beschke K , Wachsmuth H .. 1999 . Disposition and chemical stability of telmisartan 1 - O - acylglucuronide . Drug Metab Dispos 27 : 1143 - 1149 .
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 1143-1149
-
-
Ebner, T.1
Heinzel, G.2
Prox, A.3
Beschke, K.4
Wachsmuth, H.5
-
22
-
-
1642281756
-
protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
-
Evans DC , Watt AP , Nicoll - Griffith DA , Baillie TA. 2004 . Drug - protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development . Chem Res Toxicol 17 : 3 - 16 .
-
(2004)
Chem Res Toxicol
, vol.17
, pp. 3-16
-
-
Evans, D.C.1
Watt, A.P.2
Nicoll-Griffith, D.A.3
Baillie, T.A.4
-
23
-
-
0034009448
-
In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin
-
Fisher M , Campanale K , Ackermann B , Vandenbranden M , Wrighton S. 2000a . In vitro glucuronidation using human liver microsomes and the pore - forming peptide alamethicin . Drug Metab Dispos 28 : 560 - 566 .
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 560-566
-
-
Fisher, M.1
Campanale, K.2
Ackermann, B.3
Vandenbranden, M.4
Wrighton, S.5
-
24
-
-
0033661491
-
Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank
-
Fisher MB , VandenBranden M , Findlay K , Burchell B , Thummel KE , Hall SD , Wrighton SA. 2000b . Tissue distribution and interindividual variation in human UDP - glucuronosyltransferase activity: Relationship between UGT1A1 promoter genotype and variability in a liver bank . Pharmacogenetics 10 : 727 - 739 .
-
(2000)
Pharmacogenetics
, vol.10
, pp. 727-739
-
-
Fisher, M.B.1
VandenBranden, M.2
Findlay, K.3
Burchell, B.4
Thummel, K.E.5
Hall, S.D.6
Wrighton, S.A.7
-
25
-
-
0029786432
-
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
-
Fromm MF , Busse D , Kroemer HK , Eichelbaum M .. 1996 . Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin . Hepatology 24 : 796 - 801 .
-
(1996)
Hepatology
, vol.24
, pp. 796-801
-
-
Fromm, M.F.1
Busse, D.2
Kroemer, H.K.3
Eichelbaum, M.4
-
26
-
-
11144221180
-
Codeine intoxication associated with ultrarapid CYP2D6 metabolism
-
Gasche Y , Daali Y , Fathi M , Chiappe A , Cottini S , Dayer P , Desmeules J . 2004 . Codeine intoxication associated with ultrarapid CYP2D6 metabolism . N Engl J Med 351 : 2827 - 2831 .
-
(2004)
N Engl J Med
, vol.351
, pp. 2827-2831
-
-
Gasche, Y.1
Daali, Y.2
Fathi, M.3
Chiappe, A.4
Cottini, S.5
Dayer, P.6
Desmeules, J.7
-
27
-
-
29144436223
-
Membrane transporters and drug response
-
Goodman & Gilman ' s The Pharmacological Basis of Therapeutics ed. Goodman LS., Gilman A., Brunton LL., Lazo JS., Parker KL., 41-70 New York, McGraw-Hill
-
Giacomini KM , Sugiyama Y . 2006 . Membrane transporters and drug response . In Goodman & Gilman ' s The Pharmacological Basis of Therapeutics , ed. Goodman LS , Gilman A , Brunton LL , Lazo JS , Parker KL , 41 - 70 . New York : McGraw - Hill .
-
(2006)
-
-
Giacomini, K.M.1
Sugiyama, Y.2
-
28
-
-
77649216536
-
Membrane transporters in drug development
-
Giacomini KM , Huang SM , Tweedie DJ , Benet LZ , Brouwer KL , Chu X , Dahlin A , Evers R , Fischer V , Hillgren KM , Hoffmaster KA , Ishikawa T , Keppler D , Kim RB , Lee CA , Niemi M , Polli JW , Sugiyama Y , Swaan PW , Ware JA , Wright SH , Yee SW , Zamek - Gliszczynski MJ , Zhang L . 2010 . Membrane transporters in drug development . Nat Rev Drug Discov 9 : 215 - 236 .
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
Huang, S.M.2
Tweedie, D.J.3
Benet, L.Z.4
Brouwer, K.L.5
Chu, X.6
Dahlin, A.7
Evers, R.8
Fischer, V.9
Hillgren, K.M.10
Hoffmaster, K.A.11
Ishikawa, T.12
Keppler, D.13
Kim, R.B.14
Lee, C.A.15
Niemi, M.16
Polli, J.W.17
Sugiyama, Y.18
Swaan, P.W.19
Ware, J.A.20
Wright, S.H.21
Yee, S.W.22
Zamek-Gliszczynski, M.J.23
Zhang, L.24
more..
-
29
-
-
40849096159
-
Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations
-
Gertz M , Kilford PJ , Houston JB , Galetin A . 2008 . Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations . Drug Metab Dispos 36 : 535 - 542 .
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 535-542
-
-
Gertz, M.1
Kilford, P.J.2
Houston, J.B.3
Galetin, A.4
-
30
-
-
0842330657
-
Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: Implications for conversion to lamotrigine monotherapy
-
Gidal BE , Sheth R , Parnell J , Maloney K , Sale M . 2003 . Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: Implications for conversion to lamotrigine monotherapy . Epilepsy Res 57 : 85 - 93 .
-
(2003)
Epilepsy Res
, vol.57
, pp. 85-93
-
-
Gidal, B.E.1
Sheth, R.2
Parnell, J.3
Maloney, K.4
Sale, M.5
-
31
-
-
0019981083
-
Species differences in the urinary excretion of the novel primary amine conjugate: Tocainide carbamoyl O-beta-D-glucuronide
-
Gipple KJ , Chan KT , Elvin AT , Lalka D , Axelson JE . 1982 . Species differences in the urinary excretion of the novel primary amine conjugate: Tocainide carbamoyl O - beta - D - glucuronide . J Pharm Sci 71 : 1011 - 1014 .
-
(1982)
J Pharm Sci
, vol.71
, pp. 1011-1014
-
-
Gipple, K.J.1
Chan, K.T.2
Elvin, A.T.3
Lalka, D.4
Axelson, J.E.5
-
32
-
-
33644639136
-
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of effi cacy and hot fl ashes
-
Goetz MP , Rae JM , Suman VJ , Safgren SL , Ames MM , Visscher DW , Reynolds C , Couch FJ , Lingle WL , Flockhart DA , Desta Z , Perez EA , Ingle JN . 2005 . Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of effi cacy and hot fl ashes . J Clin Oncol 23 : 9312 - 9318 .
-
(2005)
J Clin Oncol
, vol.23
, pp. 9312-9318
-
-
Goetz, M.P.1
Rae, J.M.2
Suman, V.J.3
Safgren, S.L.4
Ames, M.M.5
Visscher, D.W.6
Reynolds, C.7
Couch, F.J.8
Lingle, W.L.9
Flockhart, D.A.10
Desta, Z.11
Perez, E.A.12
Ingle, J.N.13
-
33
-
-
84888746245
-
Drug metabolism
-
Goodman & Gilman ' s The Pharmacological Basis of Therapeutics ed. Goodman LS., Gilman A., Brunton LL., Lazo JS., Parker KL., 71-91 New York, McGraw-Hill
-
Gonzalez FJ , Tukey RH . 2006 . Drug metabolism . In Goodman & Gilman ' s The Pharmacological Basis of Therapeutics , ed. Goodman LS , Gilman A , Brunton LL , Lazo JS , Parker KL , 71 - 91 . New York : McGraw - Hill .
-
(2006)
-
-
Gonzalez, F.J.1
Tukey, R.H.2
-
34
-
-
0042833213
-
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity
-
Gorski J , Vannaprasaht S , Hamman M , Ambrosius W , Bruce M , Haehner - Daniels B , Hall S. 2003 . The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity . Clin Pharmacol Ther 74 : 275 - 287 .
-
(2003)
Clin Pharmacol Ther
, vol.74
, pp. 275-287
-
-
Gorski, J.1
Vannaprasaht, S.2
Hamman, M.3
Ambrosius, W.4
Bruce, M.5
Haehner-Daniels, B.6
Hall, S.7
-
35
-
-
1642441388
-
The effect of echinacea ( Echinacea purpurea root) on cytochrome P450 activity in vivo
-
Gorski JC , Huang SM , Pinto A , Hamman MA , Hilligoss JK , Zaheer NA , Desai M , Miller M , Hall SD . 2004 . The effect of echinacea ( Echinacea purpurea root) on cytochrome P450 activity in vivo . Clin Pharmacol Ther 75 : 89 - 100 .
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 89-100
-
-
Gorski, J.C.1
Huang, S.M.2
Pinto, A.3
Hamman, M.A.4
Hilligoss, J.K.5
Zaheer, N.A.6
Desai, M.7
Miller, M.8
Hall, S.D.9
-
36
-
-
33845990977
-
Determination of microsomal and hepatocyte scaling factors for in vitro in vivo extrapolation
-
Griffiths HH , Jones OO , Smith R . 2005 . Determination of microsomal and hepatocyte scaling factors for in vitro in vivo extrapolation . Drug Metab Rev 37 ( Suppl. 1 ): 71 .
-
(2005)
Drug Metab Rev
, vol.37
, Issue.SUPPL. 1
, pp. 71
-
-
Griffiths, H.H.1
Jones, O.O.2
Smith, R.3
-
37
-
-
67649389519
-
The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: A perspective of the Pharmaceutical Research and Manufacturers of America
-
Grimm SW , Einolf HJ , Hall SD , He K , Lim H - K , Ling K - HJ , Lu C , Nomeir AA , Seibert E , Skordos KW , Tonn GR , Van Horn R , Wang RW , Wong YN , Yang TJ , Obach RS. 2009 . The conduct of in vitro studies to address time - dependent inhibition of drug - metabolizing enzymes: A perspective of the Pharmaceutical Research and Manufacturers of America . Drug Metab Dispos 37 : 1355 - 1370 .
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1355-1370
-
-
Grimm, S.W.1
Einolf, H.J.2
Hall, S.D.3
He, K.4
Lim, H.-K.5
Ling, K.-H.6
Lu, C.7
Nomeir, A.A.8
Seibert, E.9
Skordos, K.W.10
Tonn, G.R.11
Van Horn, R.12
Wang, R.W.13
Wong, Y.N.14
Yang, T.J.15
Obach, R.S.16
-
38
-
-
0025895757
-
Reactions and signifi cance of cytochrome P-450 enzymes
-
Guengerich FP.. 1991 . Reactions and signifi cance of cytochrome P - 450 enzymes . J Biol Chem 266 : 10019 - 10022 .
-
(1991)
J Biol Chem
, vol.266
, pp. 10019-10022
-
-
Guengerich, F.P.1
-
39
-
-
0034970549
-
Uncommon P450-catalyzed reactions
-
Guengerich FP. 2001 . Uncommon P450 - catalyzed reactions . Curr Drug Metab 2 : 93 - 115
-
(2001)
Curr Drug Metab
, vol.2
, pp. 93-115
-
-
Guengerich, F.P.1
-
40
-
-
34047266790
-
Applying mechanisms of chemical toxicity to predict drug safety
-
Guengerich FP , MacDonald JS. 2007 . Applying mechanisms of chemical toxicity to predict drug safety . Chem Res Toxicol 20 : 344 - 369 .
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 344-369
-
-
Guengerich, F.P.1
MacDonald, J.S.2
-
41
-
-
33644893086
-
Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance
-
Hakooz N , Ito K , Rawden H , Gill H , Lemmers L , Boobis AR , Edwards JE , Carlile DJ , Lake BG , Houston BJ . 2006 . Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance . Pharm Res 23 : 533 - 539 .
-
(2006)
Pharm Res
, vol.23
, pp. 533-539
-
-
Hakooz, N.1
Ito, K.2
Rawden, H.3
Gill, H.4
Lemmers, L.5
Boobis, A.R.6
Edwards, J.E.7
Carlile, D.J.8
Lake, B.G.9
Houston, B.J.10
-
42
-
-
0025981519
-
Rapid high-performance liquid chromatography assay for the simultaneous determination of probenecid and its glucuronide in urine. Irreversible binding of probenecid to serum albumin
-
Hansen - Moller J , Schmit U.. 1991 . Rapid high - performance liquid chromatography assay for the simultaneous determination of probenecid and its glucuronide in urine. Irreversible binding of probenecid to serum albumin . J Pharm Biomed Anal 9 : 65 - 73 .
-
(1991)
J Pharm Biomed Anal
, vol.9
, pp. 65-73
-
-
Hansen-Moller, J.1
Schmit, U.2
-
43
-
-
33645100073
-
Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement
-
Hallifax D , Houston JB . 2006 . Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement . Drug Metab Dispos 34 : 724 - 726 .
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 724-726
-
-
Hallifax, D.1
Houston, J.B.2
-
44
-
-
34547163963
-
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: Mechanisms and consequences for quantitative clearance prediction
-
Hallifax D , Houston JB . 2007 . Saturable uptake of lipophilic amine drugs into isolated hepatocytes: Mechanisms and consequences for quantitative clearance prediction . Drug Metab Dispos 35 : 1325 - 1332 .
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1325-1332
-
-
Hallifax, D.1
Houston, J.B.2
-
45
-
-
0142181021
-
Metabolism and disposition of novel des-fl uoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters
-
Hayakawa H , Fukushima Y , Kato H , Fukumoto H , Kadota T , Yamamoto H , Kuroiwa H , Nishigaki J , Tsuji A . 2003 . Metabolism and disposition of novel des - fl uoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters . Drug Metab Dispos 31 : 1409 - 1418 .
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1409-1418
-
-
Hayakawa, H.1
Fukushima, Y.2
Kato, H.3
Fukumoto, H.4
Kadota, T.5
Yamamoto, H.6
Kuroiwa, H.7
Nishigaki, J.8
Tsuji, A.9
-
46
-
-
0029972195
-
The nifedipine-rifampin interaction: Evidence for induction of gut wall metabolism
-
Holtbecker N , Fromm MF , Kroemer HK , Ohnhaus EE , Heidemann H .. 1996 . The nifedipine - rifampin interaction: Evidence for induction of gut wall metabolism . Drug Metab Dispos 24 : 1121 - 1123 .
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 1121-1123
-
-
Holtbecker, N.1
Fromm, M.F.2
Kroemer, H.K.3
Ohnhaus, E.E.4
Heidemann, H.5
-
47
-
-
33745130722
-
Prediction of in vivo drug clearance from in vitro data: I. Impact of inter-individual variability
-
(accessed July 22, 2010)
-
Howgate EM , Rowland YK , Proctor NJ , Tucker GT , Rostami - Hodjegan A. 2006 . Prediction of in vivo drug clearance from in vitro data: I. Impact of inter - individual variability . Xenobiotica 36 : 473 - 497 . http://www.ema.europa.eu/ema/index.jsp?curl= pages/medicines/human/referrals/Cerivastatin/human_referral_000108.jsp&mid= WC0b01ac0580024e9a&murl=menus/regulations/regulations.jsp&jsenabled= true# (accessed July 22, 2010).
-
(2006)
Xenobiotica
, vol.36
, pp. 473-497
-
-
Howgate, E.M.1
Rowland, Y.K.2
Proctor, N.J.3
Tucker, G.T.4
Rostami-Hodjegan, A.5
-
48
-
-
44049087422
-
New era in drug interactions evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process
-
Huang SM , Strong JM , Zhang L , Reynolds KS , Nallani S , Temple R , Abraham S , Habet SA , Baweja RK , Burckart GJ , Chung S , Colangelo P , Frucht D , Green MD , Hepp P , Karnaukhova E , Ko HS , Lee JI , Marroum PJ , Norden JM , Qiu W , RahmanA , Sobel S , Stifano T , Thummel K , Wei XX , Yasuda S , Zheng JH , Zhao H , Lesko LJ . 2008 . New era in drug interactions evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process . J Clin Pharmacol 48 : 662 - 670 .
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 662-670
-
-
Huang, S.M.1
Strong, J.M.2
Zhang, L.3
Reynolds, K.S.4
Nallani, S.5
Temple, R.6
Abraham, S.7
Habet, S.A.8
Baweja, R.K.9
Burckart, G.J.10
Chung, S.11
Colangelo, P.12
Frucht, D.13
Green, M.D.14
Hepp, P.15
Karnaukhova, E.16
Ko, H.S.17
Lee, J.I.18
Marroum, P.J.19
Norden, J.M.20
Qiu, W.21
Rahman, A.22
Sobel, S.23
Stifano, T.24
Thummel, K.25
Wei, X.X.26
Yasuda, S.27
Zheng, J.H.28
Zhao, H.29
Lesko, L.J.30
more..
-
50
-
-
0033994866
-
Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: Use of maximum unbound concentration of inhibitor at the inlet to the liver
-
Kanamitsu SI , Ito K , Sugiyama Y . 2000 . Quantitative prediction of in vivo drug - drug interactions from in vitro data based on physiological pharmacokinetics: Use of maximum unbound concentration of inhibitor at the inlet to the liver . Pharm Res 17 : 336 - 343 .
-
(2000)
Pharm Res
, vol.17
, pp. 336-343
-
-
Kanamitsu, S.I.1
Ito, K.2
Sugiyama, Y.3
-
51
-
-
0032962715
-
Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative -hypnotic, zaleplon, between monkeys and rats
-
Kawashima K , Hosoi K , Naruke T , Shiba T , Kitamura M , Watabe T .. 1999 . Aldehyde oxidase - dependent marked species difference in hepatic metabolism of the sedative -hypnotic, zaleplon, between monkeys and rats . Drug Metab Dispos 27 : 422 - 428 .
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 422-428
-
-
Kawashima, K.1
Hosoi, K.2
Naruke, T.3
Shiba, T.4
Kitamura, M.5
Watabe, T.6
-
52
-
-
15244342411
-
UDP-glucuronosyltransferases and clinical drug-drug interactions
-
Kiang TKL , Ensom MHH , Chang TKH . 2005 . UDP - glucuronosyltransferases and clinical drug - drug interactions . Pharmacol Ther 106 : 97 - 132 .
-
(2005)
Pharmacol Ther
, vol.106
, pp. 97-132
-
-
Kiang, T.K.L.1
Ensom, M.H.H.2
Chang, T.K.H.3
-
53
-
-
33747134323
-
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
-
Koren G , Cairns J , Chitayat D , Gaedigk A , Leeder SJ . 2006 . Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine - prescribed mother . Lancet 368 : 704 .
-
(2006)
Lancet
, vol.368
, pp. 704
-
-
Koren, G.1
Cairns, J.2
Chitayat, D.3
Gaedigk, A.4
Leeder, S.J.5
-
54
-
-
0036894822
-
Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: Role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide
-
Kumar S , Samual K , Subramanian R , Braun MP , Stearns RA , Chiu SL , Evans DC , Baillie TA . 2002 . Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: Role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide . J Pharmacol Exp Ther 303 : 969 - 978 .
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 969-978
-
-
Kumar, S.1
Samual, K.2
Subramanian, R.3
Braun, M.P.4
Stearns, R.A.5
Chiu, S.L.6
Evans, D.C.7
Baillie, T.A.8
-
55
-
-
0036795513
-
Metabolism of zaleplon by human liver: Evidence for involvement of aldehyde oxidase
-
Lake BG , Ball SE , Kao J , Renwick AB , Price RJ , Scatina JA . 2002 . Metabolism of zaleplon by human liver: Evidence for involvement of aldehyde oxidase . Xenobiotica 32 : 835 - 847 .
-
(2002)
Xenobiotica
, vol.32
, pp. 835-847
-
-
Lake, B.G.1
Ball, S.E.2
Kao, J.3
Renwick, A.B.4
Price, R.J.5
Scatina, J.A.6
-
56
-
-
34248562343
-
Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression
-
Leone AM , Kao LM , McMillian MK , Nie AY , Parker JB , Kelley MF , Usuki E , Parkinson A , Lord PG , Johnson MD. 2007 . Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression . Chem Res Toxicol 20 : 600 - 608 .
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 600-608
-
-
Leone, A.M.1
Kao, L.M.2
McMillian, M.K.3
Nie, A.Y.4
Parker, J.B.5
Kelley, M.F.6
Usuki, E.7
Parkinson, A.8
Lord, P.G.9
Johnson, M.D.10
-
57
-
-
0032727340
-
Effects of cytochrome P450 inducers on 17alpha-ethinyloestradiol (EE2) conjugation by primary human hepatocytes
-
Li AP , Hartman NR , Lu C , Collins JM , Strong JM .. 1999 . Effects of cytochrome P450 inducers on 17alpha - ethinyloestradiol (EE2) conjugation by primary human hepatocytes . Br J Clin Pharmacol 48 : 733 - 742 .
-
(1999)
Br J Clin Pharmacol
, vol.48
, pp. 733-742
-
-
Li, A.P.1
Hartman, N.R.2
Lu, C.3
Collins, J.M.4
Strong, J.M.5
-
58
-
-
33749021098
-
Metabolite profi le of sibutramine in human urine: A liquid chromatography-electrospray ionization mass spectrometric study
-
Link M , Hakala KS , Wsol V , Kostiainen R , Ketola RA . 2006 . Metabolite profi le of sibutramine in human urine: A liquid chromatography - electrospray ionization mass spectrometric study . J Mass Spectrom 41 : 1171 - 1178 .
-
(2006)
J Mass Spectrom
, vol.41
, pp. 1171-1178
-
-
Link, M.1
Hakala, K.S.2
Wsol, V.3
Kostiainen, R.4
Ketola, R.A.5
-
59
-
-
0023792145
-
The potential role of lysosomes in tissue distribution of weak bases
-
MacIntyre AC , Cutler DJ. 1988 . The potential role of lysosomes in tissue distribution of weak bases . Biopharm Drug Dispos 9 : 513 - 526 .
-
(1988)
Biopharm Drug Dispos
, vol.9
, pp. 513-526
-
-
MacIntyre, A.C.1
Cutler, D.J.2
-
60
-
-
0037379409
-
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
-
Madan A , Graham RA , Carroll KM , Mudra DR , Burton LA , Krueger LA , Downey AD , Czerwinski M , Forster J , Ribadeneira MD , Gan L - S , LeCluyse EL , Zech K , Robertson P Jr. , Koch P , Antonian L , Wagner G , Yu L , Parkinson A. 2003 . Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes . Drug Metab Dispos 31 : 421 - 431 .
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 421-431
-
-
Madan, A.1
Graham, R.A.2
Carroll, K.M.3
Mudra, D.R.4
Burton, L.A.5
Krueger, L.A.6
Downey, A.D.7
Czerwinski, M.8
Forster, J.9
Ribadeneira, M.D.10
Gan, L.-S.11
LeCluyse, E.L.12
Zech, K.13
Robertson Jr, P.14
Koch, P.15
Antonian, L.16
Wagner, G.17
Yu, L.18
Parkinson, A.19
-
61
-
-
41549150792
-
Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry
-
Mahajan MK , Evans CA . 2008 . Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry . Rapid Commun Mass Spectrom 22 : 1032 - 1040 .
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1032-1040
-
-
Mahajan, M.K.1
Evans, C.A.2
-
62
-
-
33747585285
-
Blood conjugation and anticoagulant, thrombolytic, and antiplatelet drugs
-
Goodman & Gilman ' s The Pharmacological Basis of Therapeutics 11th ed.., ed. Goodman LS., Gilman A., Brunton LL., Lazo JS., Parker KL., 1200-1256 New York, McGraw-Hill
-
Majerus PWT , Douglas M . 2006 . Blood conjugation and anticoagulant, thrombolytic, and antiplatelet drugs . In Goodman & Gilman ' s The Pharmacological Basis of Therapeutics , 11th ed. , ed. Goodman LS , Gilman A , Brunton LL , Lazo JS , Parker KL , 1200 - 1256 . New York : McGraw - Hill .
-
(2006)
-
-
Majerus, P.W.T.1
Douglas, M.2
-
63
-
-
33749334695
-
vitro drug interaction between difl unisal and indomethacin via glucuronidation in humans
-
Mano Y , Usui T , Kamimura H . 2006 . In vitro drug interaction between difl unisal and indomethacin via glucuronidation in humans . Biopharm Drug Dispos 27 : 267 - 273 .
-
(2006)
Biopharm Drug Dispos
, vol.27
, pp. 267-273
-
-
Mano, Y.1
Usui, T.2
Kamimura, H.3
-
64
-
-
34047275727
-
Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: Correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugation formation in rats and humans
-
Masubuchi N , Makino C , Murayama N . 2007 . Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: Correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugation formation in rats and humans . Chem Res Toxicol 20 : 455 - 464 .
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 455-464
-
-
Masubuchi, N.1
Makino, C.2
Murayama, N.3
-
65
-
-
33746754115
-
Potent cytochrome P450 2C19 genotype -related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir
-
Mikus G , Schowel V , Drzewinska M , Rengelshausen J , Ding R , Riedel KD , Burhenne J , Weiss J , Thomsen T , Haefeli WE . 2006 . Potent cytochrome P450 2C19 genotype -related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir . Clin Pharmacol Ther 80 : 126 - 135 .
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 126-135
-
-
Mikus, G.1
Schowel, V.2
Drzewinska, M.3
Rengelshausen, J.4
Ding, R.5
Riedel, K.D.6
Burhenne, J.7
Weiss, J.8
Thomsen, T.9
Haefeli, W.E.10
-
66
-
-
33646077674
-
In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises
-
Miners JO , Knights KM , Houston JB , Mackenzie PI . 2006 . In vitro - in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises . Biochem Pharmacol 71 : 1531 - 1539 .
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1531-1539
-
-
Miners, J.O.1
Knights, K.M.2
Houston, J.B.3
Mackenzie, P.I.4
-
67
-
-
33750942519
-
Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: Implications for drug exposure in renal allograft recipients
-
Naesens M , Kuypers DR , Streit F , Armstrong VW , Oellerich M , Verbeke K , Vanrenterghem Y . 2006 . Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: Implications for drug exposure in renal allograft recipients . Clin Pharmacol Ther 80 : 509 - 521 .
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 509-521
-
-
Naesens, M.1
Kuypers, D.R.2
Streit, F.3
Armstrong, V.W.4
Oellerich, M.5
Verbeke, K.6
Vanrenterghem, Y.7
-
68
-
-
33748886662
-
Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone
-
Nishiyama T , Kobori T , Arai K , Ogura K , Ohnuma T , Ishii K , Hayashi K , Hiratsuka A . 2006 . Identification of human UDP - glucuronosyltransferase isoform(s) responsible for the C - glucuronidation of phenylbutazone . Arch Biochem Biophys 454 : 72 - 79 .
-
(2006)
Arch Biochem Biophys
, vol.454
, pp. 72-79
-
-
Nishiyama, T.1
Kobori, T.2
Arai, K.3
Ogura, K.4
Ohnuma, T.5
Ishii, K.6
Hayashi, K.7
Hiratsuka, A.8
-
69
-
-
13444278490
-
Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro study
-
Obach RS , Cox LM , Tremaine LM . 2005 . Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro study . Drug Metab Dispos 33 : 262 - 270 .
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 262-270
-
-
Obach, R.S.1
Cox, L.M.2
Tremaine, L.M.3
-
70
-
-
29944435424
-
Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro
-
Obach RS , Reed - Hagen AE , Krueger SS , Obach BJ , O ' Connell TN , Zandi KS , Miller S , Coe JW. 2006 . Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro . Drug Metab Dispos 34 : 121 - 130 .
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 121-130
-
-
Obach, R.S.1
Reed-Hagen, A.E.2
Krueger, S.S.3
Obach, B.J.4
O'Connell, T.N.5
Zandi, K.S.6
Miller, S.7
Coe, J.W.8
-
71
-
-
53549100467
-
Can in vitro metabolism -dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
-
Obach RS , Kalgutkar AS , Soglia JR , Zhao SX . 2008 . Can in vitro metabolism -dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose . Chem Res Toxicol 21 : 1814 - 1822 .
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1814-1822
-
-
Obach, R.S.1
Kalgutkar, A.S.2
Soglia, J.R.3
Zhao, S.X.4
-
72
-
-
29944446317
-
Glucuronidation converts gemfi brozil to a potent, metabolism -dependent inhibitor of CYP2C8: Implications for drug-drug interactions
-
Ogilvie BW , Zhang D , Li W , Rodrigues AD , Gipson AE , Holsapple J , Toren P , Parkinson A . 2006 . Glucuronidation converts gemfi brozil to a potent, metabolism -dependent inhibitor of CYP2C8: Implications for drug - drug interactions . Drug Metab Dispos 34 : 191 - 197 .
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 191-197
-
-
Ogilvie, B.W.1
Zhang, D.2
Li, W.3
Rodrigues, A.D.4
Gipson, A.E.5
Holsapple, J.6
Toren, P.7
Parkinson, A.8
-
73
-
-
70349107668
-
vitro approaches for studying the inhibition of drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450
-
2nd ed.., ed. Rodrigues AD., 231-358 New York, Informa Healthcare USA
-
Ogilvie BW , Usuki E , Yerino P , Parkinson A . 2008 . In vitro approaches for studying the inhibition of drug - metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 . In Drug - Drug Interactions , 2nd ed. , ed. Rodrigues AD , 231 - 358 . New York : Informa Healthcare USA .
-
(2008)
Drug-Drug Interactions
-
-
Ogilvie, B.W.1
Usuki, E.2
Yerino, P.3
Parkinson, A.4
-
74
-
-
29144523534
-
A human transporter protein that mediates the fi nal excretion step for toxic organic cations
-
Otsuka M , Matsumoto T , Morimoto R , Arioka S , Omote H , Moriyama Y . 2005 . A human transporter protein that mediates the fi nal excretion step for toxic organic cations . PNAS 102 : 17923 - 17928 .
-
(2005)
PNAS
, vol.102
, pp. 17923-17928
-
-
Otsuka, M.1
Matsumoto, T.2
Morimoto, R.3
Arioka, S.4
Omote, H.5
Moriyama, Y.6
-
75
-
-
0033900967
-
A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfi brozil combination therapy - A case report
-
Ozdemir O , Boran M , Gokce V , Uzun Y , Kocak B , Korkmaz S . 2000 . A case with severe rhabdomyolysis and renal failure associated with cerivastatin - gemfi brozil combination therapy - A case report . Angiology 51 : 695 - 697 .
-
(2000)
Angiology
, vol.51
, pp. 695-697
-
-
Ozdemir, O.1
Boran, M.2
Gokce, V.3
Uzun, Y.4
Kocak, B.5
Korkmaz, S.6
-
76
-
-
33745159659
-
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction
-
Paine MF , Widmer WW , Hart HL , Pusek SN , Beavers KL , Criss AB , Brown SS , Thomas BF , Watkins PB . 2006 . A furanocoumarin - free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice - felodipine interaction . Am J Clin Nutr 83 : 1097 - 1105 .
-
(2006)
Am J Clin Nutr
, vol.83
, pp. 1097-1105
-
-
Paine, M.F.1
Widmer, W.W.2
Hart, H.L.3
Pusek, S.N.4
Beavers, K.L.5
Criss, A.B.6
Brown, S.S.7
Thomas, B.F.8
Watkins, P.B.9
-
77
-
-
0004215277
-
Biotransformation of xenobiotics
-
Casarett & Doull ' s Toxicology, The Basic Science of Poisons 7th ed.., ed. Klaassen CD., 161-304 New York, McGraw-Hill
-
Parkinson A , Ogilvie BW . 2008 . Biotransformation of xenobiotics . In Casarett & Doull ' s Toxicology : The Basic Science of Poisons , 7th ed. , ed. Klaassen CD , 161 - 304 . New York : McGraw - Hill .
-
(2008)
-
-
Parkinson, A.1
Ogilvie, B.W.2
-
79
-
-
4444268162
-
Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers
-
Pope LE , Khalil MH , Berg JE , Stiles M , Yakatan GJ , Sellers EM . 2004 . Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers . J Clin Pharmacol 44 : 1132 - 1142 .
-
(2004)
J Clin Pharmacol
, vol.44
, pp. 1132-1142
-
-
Pope, L.E.1
Khalil, M.H.2
Berg, J.E.3
Stiles, M.4
Yakatan, G.J.5
Sellers, E.M.6
-
80
-
-
0142010672
-
Modeling interindividual variation in physiological factors used in PBPK models of humans
-
Price PS , Conolly RB , Chaisson CF , Gross EA , Young JS , Mathis ET , Tedder DR . 2003 . Modeling interindividual variation in physiological factors used in PBPK models of humans . Crit Rev Toxicol 33 : 469 - 503 .
-
(2003)
Crit Rev Toxicol
, vol.33
, pp. 469-503
-
-
Price, P.S.1
Conolly, R.B.2
Chaisson, C.F.3
Gross, E.A.4
Young, J.S.5
Mathis, E.T.6
Tedder, D.R.7
-
81
-
-
1542344547
-
Predicting drug clearance from recombinantly expressed CYPs: Intersystem extrapolation factors
-
Proctor NJ , Tucker GT , Rostami - Hodjegan A. 2004 . Predicting drug clearance from recombinantly expressed CYPs: Intersystem extrapolation factors . Xenobiotica 34 : 151 - 178 .
-
(2004)
Xenobiotica
, vol.34
, pp. 151-178
-
-
Proctor, N.J.1
Tucker, G.T.2
Rostami-Hodjegan, A.3
-
82
-
-
0036794380
-
Inhibition of zaleplon metabolism by cimetidine in the human liver: In vitro studies with subcellular fractions and precision-cut liver slices
-
Renwick AB , Ball SE , Tredger JM , Price RJ , Walters DG , Kao J , Scatina JA , Lake BG . 2002 . Inhibition of zaleplon metabolism by cimetidine in the human liver: In vitro studies with subcellular fractions and precision - cut liver slices . Xenobiotica 32 : 849 - 862 .
-
(2002)
Xenobiotica
, vol.32
, pp. 849-862
-
-
Renwick, A.B.1
Ball, S.E.2
Tredger, J.M.3
Price, R.J.4
Walters, D.G.5
Kao, J.6
Scatina, J.A.7
Lake, B.G.8
-
83
-
-
0001491204
-
Transformation enzymes: Oxidative; non-P450
-
ed. Woolf T., 131-151 New York, Marcel Dekker, Inc
-
Rettie AE , Fisher MB .. 1999 . Transformation enzymes: Oxidative; non - P450 . In Handbook of Drug Metabolism , ed. Woolf T , 131 - 151 . New York : Marcel Dekker, Inc .
-
(1999)
Handbook of Drug Metabolism
-
-
Rettie, A.E.1
Fisher, M.B.2
-
84
-
-
6944232288
-
Sulfotransferase 1E1 is a low km isoform mediating the 3 - O - sulfation of ethinyl estradiol
-
Schrag ML , Cui D , Rushmore TH , Shou M , Ma B , Rodrigues AD . 2004 . Sulfotransferase 1E1 is a low km isoform mediating the 3 - O - sulfation of ethinyl estradiol . Drug Metab Dispos 32 : 1299 - 1303 .
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1299-1303
-
-
Schrag, M.L.1
Cui, D.2
Rushmore, T.H.3
Shou, M.4
Ma, B.5
Rodrigues, A.D.6
-
85
-
-
21144455220
-
Interindividual variability in 2 - hydroxylation, 3 - sulfation, and 3 - glucuronidation of ethynylestradiol in human liver
-
Shiraga T , Niwa T , Ohno Y , Kagayama A . 2004 . Interindividual variability in 2 - hydroxylation, 3 - sulfation, and 3 - glucuronidation of ethynylestradiol in human liver . Biol Pharm Bull 27 : 1900 - 1906 .
-
(2004)
Biol Pharm Bull
, vol.27
, pp. 1900-1906
-
-
Shiraga, T.1
Niwa, T.2
Ohno, Y.3
Kagayama, A.4
-
86
-
-
4644301418
-
Gemfi brozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6) -mediated hepatic uptake and CYP2C8 - mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug - drug interaction between cerivastatin and gemfi brozil
-
Shitara Y , Hirano M , Sato H , Sugiyama Y . 2004 . Gemfi brozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6) -mediated hepatic uptake and CYP2C8 - mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug - drug interaction between cerivastatin and gemfi brozil . J Pharmacol Exp Ther 311 : 228 - 236 .
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 228-236
-
-
Shitara, Y.1
Hirano, M.2
Sato, H.3
Sugiyama, Y.4
-
87
-
-
33644847684
-
Transporters as a determinant of drug clearance and tissue distribution
-
Shitara Y , Horie T , Sugiyama Y . 2006 . Transporters as a determinant of drug clearance and tissue distribution . Eur J Pharm Sci 27 : 425 - 446 .
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 425-446
-
-
Shitara, Y.1
Horie, T.2
Sugiyama, Y.3
-
88
-
-
34248156160
-
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
-
Shu Y , Sheardown SA , Brown C , Owen RP , Zhang S , Castro RA , Ianculescu AG , Yue L , Lo JC , Burchard EG , Brett CM , Giacomini KM . 2007 . Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action . J Clin Invest 117 : 1422 - 1431 .
-
(2007)
J Clin Invest
, vol.117
, pp. 1422-1431
-
-
Shu, Y.1
Sheardown, S.A.2
Brown, C.3
Owen, R.P.4
Zhang, S.5
Castro, R.A.6
Ianculescu, A.G.7
Yue, L.8
Lo, J.C.9
Burchard, E.G.10
Brett, C.M.11
Giacomini, K.M.12
-
89
-
-
0036194124
-
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
-
Soars MG , Burchell B , Riley RJ . 2002 . In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance . J Pharmacol Exp Ther 301 : 382 - 390 .
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 382-390
-
-
Soars, M.G.1
Burchell, B.2
Riley, R.J.3
-
90
-
-
33745049731
-
In vivo use of the P450 inactivator 1 - aminobenzotriazole in the rat: Varied dosing route to elucidate gut and liver contributions to fi rst - pass and systemic clearance
-
Strelevitz TJ , Foti RS , Fisher MB . 2006 . In vivo use of the P450 inactivator 1 - aminobenzotriazole in the rat: Varied dosing route to elucidate gut and liver contributions to fi rst - pass and systemic clearance . J Pharm Sci 95 : 1334 - 1341 .
-
(2006)
J Pharm Sci
, vol.95
, pp. 1334-1341
-
-
Strelevitz, T.J.1
Foti, R.S.2
Fisher, M.B.3
-
91
-
-
0030058077
-
Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide
-
Sugihara K , Kitamura S , Tatsumi K .. 1996 . Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide . Drug Metab Dispos 24 :. 199 - 202 .
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 199-202
-
-
Sugihara, K.1
Kitamura, S.2
Tatsumi, K.3
-
92
-
-
50049084336
-
Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity
-
Takakusa H , Masumoto H , Yukinaga H , Makino C , Nakayama S , Okazaki O , Sudo K. 2008a . Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity . Drug Metab Dispos 36 : 1770 - 1779 .
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1770-1779
-
-
Takakusa, H.1
Masumoto, H.2
Yukinaga, H.3
Makino, C.4
Nakayama, S.5
Okazaki, O.6
Sudo, K.7
-
93
-
-
0024345539
-
Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3 '?- hydroxyacetanilide, in mouse liver
-
Tirmenstein MA , Nelson SD . 1989 . Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3 '?- hydroxyacetanilide, in mouse liver . J Biol Chem 264 : 9814 - 9819 .
-
(1989)
J Biol Chem
, vol.264
, pp. 9814-9819
-
-
Tirmenstein, M.A.1
Nelson, S.D.2
-
94
-
-
1342265867
-
Inhibition of organic anion transporting polypeptide - mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat
-
Treiber A , Schneiter R , Delahaye S , Clozel M . 2004 . Inhibition of organic anion transporting polypeptide - mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat . J Pharmacol Exp Ther 308 : 1121 - 1129 .
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 1121-1129
-
-
Treiber, A.1
Schneiter, R.2
Delahaye, S.3
Clozel, M.4
-
95
-
-
0024561543
-
Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline
-
Tremaine LM , Stroh JG , Ronfeld RA . 1989 . Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline . Drug Metab Dispos 17 : 58 - 63 .
-
(1989)
Drug Metab Dispos
, vol.17
, pp. 58-63
-
-
Tremaine, L.M.1
Stroh, J.G.2
Ronfeld, R.A.3
-
96
-
-
0032700543
-
Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as in vivo probe: Effect of ketoconazole
-
Tsunoda SM , Velez RL , von Moltke LL , Greenblatt DJ.. 1999 . Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as in vivo probe: Effect of ketoconazole . Clin Pharmacol Ther 66 : 461 - 471 .
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 461-471
-
-
Tsunoda, S.M.1
Velez, R.L.2
von Moltke, L.L.3
Greenblatt, D.J.4
-
97
-
-
0034807892
-
Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Toward a consensus
-
Tucker GT , Houston JB , Huang SM . 2001 . Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Toward a consensus .Pharm Res 18 : 1071 - 1080 .
-
(2001)
Pharm Res
, vol.18
, pp. 1071-1080
-
-
Tucker, G.T.1
Houston, J.B.2
Huang, S.M.3
-
99
-
-
53549097600
-
-
US Food and Drug Administration (US FDA)
-
US Food and Drug Administration (US FDA) . 2008 . Guidance for Industry Safety Testing of Drug Metabolites . http://www.fda.gov/downloads/Drugs/Guidance ComplianceRegulatoryInformation/Guidances/ucm079266.pdf.
-
(2008)
Guidance for Industry Safety Testing of Drug Metabolites
-
-
-
101
-
-
0348038711
-
Reaction phenotyping in drug discovery: Moving forward with confi dence?
-
Williams JA , Hurst SI , Bauman J , Jones BC , Hyland R , Gibbs JP , Obach RS , Ball SE . 2003 . Reaction phenotyping in drug discovery: Moving forward with confi dence? Curr Drug Metab 4 : 527 - 534 .
-
(2003)
Curr Drug Metab
, vol.4
, pp. 527-534
-
-
Williams, J.A.1
Hurst, S.I.2
Bauman, J.3
Jones, B.C.4
Hyland, R.5
Gibbs, J.P.6
Obach, R.S.7
Ball, S.E.8
-
102
-
-
6944221357
-
Drug - drug interactions for UDP - glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCI/ AUC) ratios
-
Williams JA , Hyland R , Jones BC , Smith DA , Hurst S , Goosen TC , Peterkin V , Koup JR , Ball SE . 2004 . Drug - drug interactions for UDP - glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCI/ AUC) ratios . Drug Metab Dispos 32 : 1201 - 1208 .
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1201-1208
-
-
Williams, J.A.1
Hyland, R.2
Jones, B.C.3
Smith, D.A.4
Hurst, S.5
Goosen, T.C.6
Peterkin, V.7
Koup, J.R.8
Ball, S.E.9
-
103
-
-
17644380257
-
Predicting drug disposition via application of BCS: Transport/ absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
-
Wu CY , Benet LZ . 2005 . Predicting drug disposition via application of BCS: Transport/ absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system . Pharm Res 22 ( 1 ): 11 - 23 .
-
(2005)
Pharm Res
, vol.22
, Issue.1
, pp. 11-23
-
-
Wu, C.Y.1
Benet, L.Z.2
-
104
-
-
42149153187
-
Application of CYP3A4 in vitro data to predict clinical durg - durg interactions; predictions of compounds as objects of interaction
-
Youdim KA , Zayed A , Dickins M , Phipps A , Griffiths M , Darekar A , Hyland R , Fahmi O , Hurst S , Plowchalk DR , Cook J , Guo F , Obach RS . 2008. Application of CYP3A4 in vitro data to predict clinical durg - durg interactions; predictions of compounds as objects of interaction . Br J Clin Pharmacol 65 : 680 - 692 .
-
(2008)
Br J Clin Pharmacol
, vol.65
, pp. 680-692
-
-
Youdim, K.A.1
Zayed, A.2
Dickins, M.3
Phipps, A.4
Griffiths, M.5
Darekar, A.6
Hyland, R.7
Fahmi, O.8
Hurst, S.9
Plowchalk, D.R.10
Cook, J.11
Guo, F.12
Obach, R.S.13
-
105
-
-
10744233849
-
Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae
-
Zhang J , Visser F , Vickers MF , Lang T , Robins MJ , Nielsen LPC , Nowak I , Baldwin SA , Young JD , Cass CE . 2003 . Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae . Mol Pharmacol 64 : 1512 - 1520 .
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1512-1520
-
-
Zhang, J.1
Visser, F.2
Vickers, M.F.3
Lang, T.4
Robins, M.J.5
Nielsen, L.P.C.6
Nowak, I.7
Baldwin, S.A.8
Young, J.D.9
Cass, C.E.10
-
106
-
-
68249162213
-
Predicting drug - drug interactions: An FDA perspective
-
Zhang L , Zhang YD , Zhao P , Huang SM . 2009 . Predicting drug - drug interactions: An FDA perspective . AAPS J 11 : 300 - 306 .
-
(2009)
AAPS J
, vol.11
, pp. 300-306
-
-
Zhang, L.1
Zhang, Y.D.2
Zhao, P.3
Huang, S.M.4
-
107
-
-
10044291653
-
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or effi cacy in hypertension
-
Zineh I , Beitelshees AL , Gaedigk A , Walker JR , Pauly DF , Eberst K , Leeder JS , Phillips MS , Gelfand CA , Johnson JA . 2004 . Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or effi cacy in hypertension . Clin Pharmacol Ther 76 : 536 - 544 .
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 536-544
-
-
Zineh, I.1
Beitelshees, A.L.2
Gaedigk, A.3
Walker, J.R.4
Pauly, D.F.5
Eberst, K.6
Leeder, J.S.7
Phillips, M.S.8
Gelfand, C.A.9
Johnson, J.A.10
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