Is it the end of the road for synthetic starches in critical illness?

BMJ (Online)

Volumn 346, Issue 7900, 2013, Pages

  Prowle, John R ^a   Pearse, Rupert M ^b  

^a BARTS HEALTH NHS TRUST   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GELATIN; HETASTARCH; INFUSION FLUID; PLASMA SUBSTITUTE; STARCH;

ACUTE KIDNEY FAILURE; BLOOD CLOTTING DISORDER; BLOOD VESSEL TONE; CAPILLARY PERMEABILITY; CARBOHYDRATE ANALYSIS; CHEMICAL MODIFICATION; CIRCULATION; CLINICAL ASSESSMENT; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; CRYSTALLOID; DRUG HALF LIFE; EDEMA; EDITORIAL; ERYTHROCYTE TRANSFUSION; FLUID RESUSCITATION; FOLLOW UP; HEART OUTPUT; HUMAN; HYPOVOLEMIA; INTENSIVE CARE UNIT; META ANALYSIS (TOPIC); MOLECULAR WEIGHT; PLASMA VOLUME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RENAL REPLACEMENT THERAPY; RISK FACTOR; SEPSIS; SYSTEMATIC REVIEW (TOPIC); THERAPY EFFECT; TISSUE PERFUSION; TREATMENT OUTCOME;

FLUID THERAPY; HETASTARCH; HUMANS; ISOTONIC SOLUTIONS; SEPSIS; SERUM ALBUMIN;

EID: 84875468314     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f1805     Document Type: Editorial

References (14)

1. Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, et al. Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis. BMJ 2013;346:f839.
2. Jungheinrich C, Neff TA. Pharmacokinetics of hydroxyethyl starch. Clin Pharmacokinet 2005;44:681-99. (Pubitemid 40994079)
3. Hartog CS, Bauer M, Reinhart K. The efficacy and safety of colloid resuscitation in the critically ill. Anesth Analg 2011;112:156-64.
4. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA 2013;309:678-88.
5. Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2013;2:CD000567.
6. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008;358:125-39.
7. Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med 2012;367:124-34.
8. Lai CF, Wu VC, Huang TM, Yeh YC, Wang KC, Han YY, et al. Kidney function decline after a non-dialysis-requiring acute kidney injury is associated with higher long-term mortality in critically ill survivors. Crit Care 2012;16:R123.
9. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350:2247-56. (Pubitemid 38669207)
10. Finfer S, Liu B, Taylor C, Bellomo R, Billot L, Cook D, et al. Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units. Crit Care 2010;14:R185.
11. Pearse RM, Ackland GL. Perioperative fluid therapy. BMJ 2012;344:e2865.
12. Cochrane Injuries Group Albumin Reviewers. Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ 1998;317:235-40.
13. Wise J. Boldt: the great pretender. BMJ 2013;346:f1738.
14. Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 2012;367:1901-11.