The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Köprülü, Afitap Derya ^a   Kastner, Renate ^b,e   Wienerroither, Sebastian ^b   Lassnig, Caroline ^c   Putz, Eva Maria ^c   Majer, Olivia ^d   Reutterer, Benjamin ^b,f   Sexl, Veronika ^c   Kuchler, Karl ^d   Müller, Mathias ^c   Decker, Thomas ^b   Ellmeier, Wilfried ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^f Marinomed Biotechnologie GmbH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BRUTON TYROSINE KINASE; INTERFERON; INTERLEUKIN 12P40; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERIAL LOAD; BONE MARROW DERIVED MACROPHAGE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ESCHERICHIA COLI; FEMALE; IMMUNOREGULATION; INFECTION SENSITIVITY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; MACROPHAGE FUNCTION; MALE; MOUSE; MUTANT; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PROTEIN FUNCTION; SURVIVAL TIME; WILD TYPE;

ANIMALS; BONE MARROW CELLS; CYTOKINES; DISEASE SUSCEPTIBILITY; ENZYME ACTIVATION; IMMUNOBLOTTING; LIPOPEPTIDES; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; PHAGOCYTOSIS; PHAGOSOMES; PROTEIN-TYROSINE KINASES;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES; MUS; POSIBACTERIA;

EID: 84875440826     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060476     Document Type: Article

References (41)

1. Mohamed AJ, Yu L, Backesjo CM, Vargas L, Faryal R, et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev 228: 58-73.
2. Koprulu AD, Ellmeier W, (2009) The role of Tec family kinases in mononuclear phagocytes. Crit Rev Immunol 29: 317-333.
3. Honda F, Kano H, Kanegane H, Nonoyama S, Kim ES, et al. (2012) The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils. Nat Immunol 13: 369-378.
4. Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, et al. (2003) Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem 278: 26258-26264.
5. Mukhopadhyay S, Mohanty M, Mangla A, George A, Bal V, et al. (2002) Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance. J Immunol 168: 2914-2921.
6. Mukhopadhyay S, George A, Bal V, Ravindran B, Rath S, (1999) Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction. J Immunol 163: 1786-1792.
7. Mangla A, Khare A, Vineeth V, Panday NN, Mukhopadhyay A, et al. (2004) Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. Blood 104: 1191-1197.
8. Doyle SL, Jefferies CA, O'Neill LA, (2005) Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J Biol Chem 280: 23496-23501.
9. Vijayan V, Baumgart-Vogt E, Naidu S, Qian G, Immenschuh S, (2011) Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages. J Immunol 187: 817-827.
10. Amoras AL, Kanegane H, Miyawaki T, Vilela MM, (2003) Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients. J Investig Allergol Clin Immunol 13: 181-188.
11. Horwood NJ, Page TH, McDaid JP, Palmer CD, Campbell J, et al. (2006) Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production. J Immunol 176: 3635-3641.
12. Perez de Diego R, Lopez-Granados E, Pozo M, Rodriguez C, Sabina P, et al. (2006) Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes. J Allergy Clin Immunol 117: 1462-1469.
13. Gonzalez-Serrano ME, Estrada-Garcia I, Mogica-Martinez D, Gonzalez-Garay A, Lopez-Herrera G, et al. (2012) Increased Pro-inflammatory Cytokine Production After Lipopolysaccharide Stimulation in Patients with X-linked Agammaglobulinemia. J Clin Immunol 32: 967-974.
14. Marron TU, Martinez-Gallo M, Yu JE, Cunningham-Rundles C, (2012) Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines. J Allergy Clin Immunol 129: 184-190 e181-184.
15. Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, et al. (2006) MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281: 10489-10495.
16. Stavru F, Archambaud C, Cossart P, (2011) Cell biology and immunology of Listeria monocytogenes infections: novel insights. Immunol Rev 240: 160-184.
17. Williams MA, Schmidt RL, Lenz LL, (2012) Early events regulating immunity and pathogenesis during Listeria monocytogenes infection. Trends Immunol 33: 488-495.
18. Leber JH, Crimmins GT, Raghavan S, Meyer-Morse NP, Cox JS, et al. (2008) Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog 4: e6.
19. Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, et al. (2012) Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity. Adv Immunol 113: 135-156.
20. Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
21. Corr SC, O'Neill LA, (2009) Listeria monocytogenes infection in the face of innate immunity. Cell Microbiol 11: 703-709.
22. Yang P, An H, Liu X, Wen M, Zheng Y, et al. (2010) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11: 487-494.
23. Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, et al. (1995) Defective B cell development and function in Btk-deficient mice. Immunity 3: 283-299.
24. Baccarini M, Bistoni F, Lohmann-Matthes ML, (1985) In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells. J Immunol 134: 2658-2665.
25. Burgess AW, Metcalf D, Kozka IJ, Simpson RJ, Vairo G, et al. (1985) Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium. J Biol Chem 260: 16004-16011.
26. Kocks C, Gouin E, Tabouret M, Berche P, Ohayon H, et al. (1992) L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell 68: 521-531.
27. Reutterer B, Stockinger S, Pilz A, Soulat D, Kastner R, et al. (2008) Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence. Cell Microbiol 10: 1116-1129.
28. Yin J, Ferguson TA, (2009) Identification of an IFN-gamma-producing neutrophil early in the response to Listeria monocytogenes. J Immunol 182: 7069-7073.
29. Shaughnessy LM, Swanson JA, (2007) The role of the activated macrophage in clearing Listeria monocytogenes infection. Front Biosci 12: 2683-2692.
30. Melcher M, Unger B, Schmidt U, Rajantie IA, Alitalo K, et al. (2008) Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol 180: 8048-8056.
31. Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, et al. (1996) Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4: 515-525.
32. Nathan C, (1997) Inducible nitric oxide synthase: what difference does it make? J Clin Invest 100: 2417-2423.
33. Jongstra-Bilen J, Puig Cano A, Hasija M, Xiao H, Smith CI, et al. (2008) Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis. J Immunol 181: 288-298.
34. Torres D, Barrier M, Bihl F, Quesniaux VJ, Maillet I, et al. (2004) Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun 72: 2131-2139.
35. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, et al. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 97: 13766-13771.
36. Dunn PL, North RJ, (1991) Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun 59: 2892-2900.
37. Tripp CS, Wolf SF, Unanue ER, (1993) Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A 90: 3725-3729.
38. Ohteki T, Fukao T, Suzue K, Maki C, Ito M, et al. (1999) Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med 189: 1981-1986.
39. Bao Y, Zheng J, Han C, Jin J, Han H, et al. (2012) Tyrosine kinase Btk is required for NK cell activation. J Biol Chem.
40. Myers JT, Tsang AW, Swanson JA, (2003) Localized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages. J Immunol 171: 5447-5453.
41. Bao Y, Han Y, Chen Z, Xu S, Cao X, (2011) IFN-alpha-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells. Eur J Immunol 41: 657-668.