Ranolazine-induced myopathy in a patient on chronic statin therapy

Journal of Clinical Neuromuscular Disease

Volumn 14, Issue 3, 2013, Pages 114-116

  Correa, Daniel ^a   Landau, Mark ^b  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b Department of the Army ^*  (United States)

Author keywords

creatine kinase; drug interactions; myopathy; ranolazine; statin

Indexed keywords

ATORVASTATIN; CREATINE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; RANOLAZINE; SIMVASTATIN;

AGED; BACKACHE; CASE REPORT; CREATINE KINASE BLOOD LEVEL; DIZZINESS; DRUG WITHDRAWAL; EDEMA; ELECTROMYOGRAPHY; FEMALE; GAIT; HUMAN; HYPERLIPIDEMIA; LEG PAIN; LIMB WEAKNESS; MOTOR UNIT POTENTIAL; MUSCLE STRENGTH; MYOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; SIDE EFFECT;

ACETANILIDES; AGED, 80 AND OVER; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MUSCULAR DISEASES; PIPERAZINES; PYRROLES;

EID: 84875434213     PISSN: 15220443     EISSN: 15371611     Source Type: Journal    
DOI: 10.1097/CND.0b013e31828525a5     Document Type: Review

References (6)

1. Wilson SR, Scirica BM, Braunwald E, et al. Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial. J Am Coll Cardiol. 2009;53: 1510-1516.
2. Rifkin SI. Multiple drug interactions in a renal transplant patient lead to simvastatin induced rhabdomyolysis: a case report. Medscape J Med. 2008;10:264.
3. Hylton AC, Ezekiel TO. Rhabdomyolysis in a patient receiving ranolazine and simvastatin. Am J Health Syst Pharm. 2010;67:1829-1831.
4. Thompson PD, Clarkson PM, Rosenson RS. An assessment of statin safety by muscle experts. Am J Cardiol. 2006;97:69C-76C.
5. Thompson PD, Clarkson PM, Karas RH. Statinassociated myopathy. JAMA. 2003;289:1681-1690.
6. Jerling M, Huan BL, Leung K, et al. Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects. J Clin Pharmacol. 2005;45:422-433.