IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients

Journal of Investigational Allergology and Clinical Immunology

Volumn 23, Issue 2, 2013, Pages 107-111

  Micheal, S ^a,b   Minhas, K ^a   Ishaque, M ^a   Ahmed, F ^c   Ahmed, A ^a  

^a COMSATS Institute of Information Technology ^*  (Pakistan)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NATIONAL INSTITUTE OF HEALTH   (Pakistan)

Author keywords

Allergic rhinitis; Atopic asthma; Disease associated; IL 4; Polymorphism

Indexed keywords

INTERLEUKIN 4; MESSENGER RNA;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; ATOPY; CONTROLLED STUDY; CYTOKINE RESPONSE; ENVIRONMENTAL FACTOR; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; IL4 GENE; MAJOR CLINICAL STUDY; PAKISTAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; ASTHMA; CASE-CONTROL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-4; PAKISTAN; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RHINITIS, ALLERGIC, PERENNIAL;

EID: 84875424074     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. de Guia RM, Ramos JD. The -590C/T IL4 single-nucleotide polymorphism as a genetic factor of atopic allergy. Int J Mol Epidemiol Genet. 2010;1:67-73.
2. Burchard EG, Silverman EK, Rosenwasser LJ, Borish L, Yandava C, Pillari A, Weiss ST, Hasday J, Lilly CM, Ford JG, Drazen JM. Association between a sequence variant in the IL-4 gene promoter and FEV1 in asthma. Am J Respir Crit Care Med. 1999;160:919-22.
3. Bucková D, Hollá LI, Vasků A, Znojil V, Vácha J. Lack of association between atopic asthma and the tumor necrosis factor alpha-308 gene polymorphism in a Czech population. J Invest Allergol Clin Immunol. 2002;12:192-7.
4. Dolganov G, Bort S, Lovett M, Burr J, Schubert L, Short D, McGurn M, Gibson C, Lewis DB. Co-expression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood. 1996;87:3316-26.
5. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, le Söuef PN, Lathrop GM, Musk AW, Cookson WO.A genome wide search for quantitative trait loci underlying asthma. Nature. 1996;383:247-50.
6. Deichmann KA, Heinzmann A, Forster J, Dischinger S, Mehl C, Brueggenolte E, Hildebrandt F, Moseler M, Kuehr J.Linkage and allelic association of atopy and markers flanking the IL-4 receptor gene. Clin Exp Allergy. 1998;28:151-5.
7. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy. 1995; 25(Suppl. 2):74-78.
8. Noguchi E, Shibasaki M, Arinami T, Takeda K, Yokouchi Y, Kawashima T, Yanagi H, Matsui A, Hamaguchi H. Association of asthma and the inteleukin-4 promoter gene in Japanese. Clin Exp Allergy. 1998;28:449-53.
9. Basehore MJ, Howard TD, Lange LA, Moore WC, Hawkins GA, Marshik PL, Harkins MS, Meyers DA, Bleecker ER. A comprehensive evaluation of IL4 variants in ethnically diverse populations: Association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol. 2004;114: 80-7.
10. Kabesch M, Tzotcheva I, Carr D, Höfler C, Weiland SK, Fritzsch C, von Mutius E, Martinez FD. A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. J Allergy Clin Immunol. 2003;112:893-8
11. Walley AJ, Cookson WO. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet. 1996; 33:689-92.
12. Hijazi Z, Haider MZ. Interleukin-4 gene promoter polymorphism C590T and asthma in Kuwaiti Arabs. Int Arch Allergy Immunol. 2000;122:190-4
13. Cui T, Wu J, Pan S, Xie J. Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma. Clin Chem Lab Med. 2003;41:888-92.
14. de Faria IC, de Faria EJ, Toro AA, Ribeiro JD, Bertuzzo CS. Association of TGF-1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr (Rio J). 2008;84:203-10.
15. Nagarkatti R, Kumar R, Sharma SK, Ghosh B. Association of IL4 gene polymorphisms with asthma in North Indians. Int Arch Allergy Immunol. 2004;134: 206-12.
16. Bijanzadeh M, Ramachandra NB, Mahesh PA, Mysore RS, Kumar P, Manjunath BS, Jayaraj BS. Association of IL-4 and ADAM33 Gene Polymorphisms with Asthma in an Indian Population. Lung. 2010;188:415-22.
17. Noguchi E, Nukaga-Nishio Y, Jian Z, Yokouchi Y, Kamioka M, Yamakawa-Kobayashi K, Hamaguchi H,Matsui A, Shibasaki M, Arinami T. Haplotupes of the 5'region of the IL-4 gene and SNPs in the inter gene sequence between the IL-4 and IL-13 genes are associated with atopic asthma. Human Immunology. 2001;62:1251-7.
18. Woitsch B, Carr D, Stachel D, Schmid I, Weiland SK, Fritzsch C, von Mutius E, Kabesch M. Comprehensive Analysis of Interleukin-4 Receptor Polymorphisms and Their Association with Atopy and IgE Regulation in Childhood. Int Arch Allergy Immunol. 2004;135:319-24.
19. Chiang CH, Tang YC, Lin MW, Chung MY. Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese. Respirology. 2007;12:42-8.
20. Chinetti G, Fruchart JC, Staels B. Peroxisome proliferatoractivated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res. 2000;49:497-505.
21. Marx N, Kehrle B, Kohlhammer K, Grüb M, Koenig W, Hombach V, Libby P, Plutzky J. PPAR activators as anti-inflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation associated arteriosclerosis. Circ Res. 2002;90:703-10.
22. Yang XX, Li FX, Wu YS, Wu D, Tan JY, Li M. Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population. Asian Pac J Allergy Immunol. 2011;29:273-7.
23. Gervaziev YV, Kaznacheev VA, Gervazieva VB. Allelic polymorphisms in the Interleukin-4 promoter regions and their association with bronchial asthma among the Russian population. Int Arch Allergy Immunol. 2006;141:257-64.