Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Development (Cambridge)

Volumn 140, Issue 8, 2013, Pages 1676-1683

  Chi, Woo ^a   Wu, Eleanor ^a   Morgan, Bruce A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Dermal papilla; Hair; Stem cell niche

Indexed keywords

DOXYCYCLINE;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL REGENERATION; CONTROLLED STUDY; DERMAL PAPILLA CELL; HAIR; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HAIR SIZE; IN VIVO STUDY; KERATINOCYTE; MORPHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CELL;

ANIMALS; CELL COUNT; CELL PROLIFERATION; DERMIS; DOXYCYCLINE; HAIR; HAIR FOLLICLE; KERATINOCYTES; MESENCHYMAL STROMAL CELLS; MICE; MICE, TRANSGENIC;

MUS;

EID: 84875421255     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.090662     Document Type: Article

References (25)

1. Alcaraz, M. V., Villena, A. and Pérez de Vargas, I. (1993). Quantitative study of the human hair follicle in normal scalp and androgenetic alopecia. J. Cutan. Pathol. 20, 344-349.
2. Belteki, G., Haigh, J., Kabacs, N., Haigh, K., Sison, K., Costantini, F., Whitsett, J., Quaggin, S. E. and Nagy, A. (2005). Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res. 33, e51.
3. Biernaskie, J., Paris, M., Morozova, O., Fagan, B. M., Marra, M., Pevny, L. and Miller, F. D. (2009). SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell 5, 610-623.
4. Chi, W. Y., Enshell-Seijffers, D. and Morgan, B. A. (2010). De novo production of dermal papilla cells during the anagen phase of the hair cycle. J. Invest. Dermatol. 130, 2664-2666.
5. Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W. and Watt, F. M. (2009). Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development 136, 2815-2823.
6. Driskell, R. R., Juneja, V. R., Connelly, J. T., Kretzschmar, K., Tan, D. W. and Watt, F. M. (2012). Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J. Invest. Dermatol. 132, 1084-1093.
7. Elliott, K., Stephenson, T. J. and Messenger, A. G. (1999). Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J. Invest. Dermatol. 113, 873-877.
8. Enshell-Seijffers, D., Lindon, C. and Morgan, B. A. (2008). The serine protease Corin is a novel modifier of the Agouti pathway. Development 135, 217-225.
9. Enshell-Seijffers, D., Lindon, C., Kashiwagi, M. and Morgan, B. A. (2010a). Beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev. Cell 18, 633-642.
10. Enshell-Seijffers, D., Lindon, C., Wu, E., Taketo, M. M. and Morgan, B. A. (2010b). Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc. Natl. Acad. Sci. USA 107, 21564-21569.
11. Garza, L. A., Yang, C. C., Zhao, T., Blatt, H. B., Lee, M., He, H., Stanton, D. C., Carrasco, L., Spiegel, J. H., Tobias, J. W. et al. (2011). Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J. Clin. Invest. 121, 613-622.
12. Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., Dela Cruz-Racelis, J. and Fuchs, E. (2009). A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4, 155-169.
13. Ibrahim, L. and Wright, E. A. (1982). A quantitative study of hair growth using mouse and rat vibrissal follicles. I. Dermal papilla volume determines hair volume. J. Embryol. Exp. Morphol. 72, 209-224.
14. Kligman, A. M. (1988). The comparative histopathology of male-pattern baldness and senescent baldness. Clin. Dermatol. 6, 108-118.
15. Lee, P., Morley, G., Huang, Q., Fischer, A., Seiler, S., Horner, J. W., Factor, S., Vaidya, D., Jalife, J. and Fishman, G. I. (1998). Conditional lineage ablation to model human diseases. Proc. Natl. Acad. Sci. USA 95, 11371-11376.
16. Legué, E. and Nicolas, J. F. (2005). Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development 132, 4143-4154.
17. Miranda, B. H., Tobin, D. J., Sharpe, D. T. and Randall, V. A. (2010). Intermediate hair follicles: a new more clinically relevant model for hair growth investigations. Br. J. Dermatol. 163, 287-295.
18. Plikus, M. V., Mayer, J. A., de la Cruz, D., Baker, R. E., Maini, P. K., Maxson, R. and Chuong, C. M. (2008). Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451, 340-344.
19. Plikus, M. V., Baker, R. E., Chen, C. C., Fare, C., de la Cruz, D., Andl, T., Maini, P. K., Millar, S. E., Widelitz, R. and Chuong, C. M. (2011). Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science 332, 586-589.
20. Rompolas, P., Deschene, E. R., Zito, G., Gonzalez, D. G., Saotome, I., Haberman, A. M. and Greco, V. (2012). Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature 487, 496-499.
21. Sharov, A. A., Sharova, T. Y., Mardaryev, A. N., Tommasi di Vignano, A., Atoyan, R., Weiner, L., Yang, S., Brissette, J. L., Dotto, G. P. and Botchkarev, V. A. (2006). Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc. Natl. Acad. Sci. USA 103, 18166-18171.
22. Srinivas, S., Watanabe, T., Lin, C. S., William, C. M., Tanabe, Y., Jessell, T. M. and Costantini, F. (2001). Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4.
23. Sun, T. T., Cotsarelis, G. and Lavker, R. M. (1991). Hair follicular stem cells: the bulge-activation hypothesis. J. Invest. Dermatol. 96, 77S-78S.
24. Van Scott, E. J. and Ekel, T. M. (1958). Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J. Invest. Dermatol. 31, 281-287.
25. Wang, L., Sharma, K., Deng, H. X., Siddique, T., Grisotti, G., Liu, E. and Roos, R. P. (2008). Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology. Neurobiol. Dis. 29, 400-408.