Strontium ranelate prevents the deleterious action of advanced glycation endproducts on osteoblastic cells via calcium channel activation

European Journal of Pharmacology

Volumn 706, Issue 1-3, 2013, Pages 41-47

  Fernández, Juan Manuel ^a   Molinuevo, María Silvina ^a   Sedlinsky, Claudia ^a   Schurman, León ^a   Cortizo, Ana María ^a   McCarthy, Antonio Desmond ^a  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

Author keywords

Advanced glycation endproducts; b Catenin; Calcium channels; Extracellular regulated kinases; Osteoblasts; Strontium ranelate

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADVANCED GLYCATION END PRODUCT; BETA CATENIN; BOVINE SERUM ALBUMIN; CALCIUM CHANNEL; CYTOKINE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NIFEDIPINE; STRONTIUM RANELATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANIMALS; BETA CATENIN; BONE DENSITY CONSERVATION AGENTS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; COLLAGEN TYPE I; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOSYLATION END PRODUCTS, ADVANCED; INTERLEUKIN-1BETA; MICE; NIFEDIPINE; OSTEOBLASTS; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875388775     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.02.042     Document Type: Article

References (39)

1. M. Alikhani, Z. Alikhani, C. Boyd, C.M. MacLellan, M. Raptis, R. Liu, N. Pischon, P.C. Trackman, L. Gerstenfeld, and D.T. Graves Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways Bone 40 2007 345 353
2. P. Ammann Strontium ranelate: a novel mode of action leading to renewed bone quality Osteoporos. Int. 16 Suppl. 1 2005 S11 15
3. A. Bierhaus, P.M. Humpert, D.M. Stern, B. Arnold, and P.P. Nawroth Advanced glycation end product receptor-mediated cellular dysfunction Ann. N.Y. Acad. Sci. 1043 2005 676 680
4. H.C. Blair, P.H. Schlesinger, C.L. Huang, and M. Zaidi Calcium signalling and calcium transport in bone disease Subcell. Biochem 45 2007 539 562
5. E. Boanini, P. Torricelli, M. Fini, and A. Bigi Osteopenic bone cell response to strontium-substituted hydroxyapatite J. Mater. Sci. - Mater. Med. 22 2011 2079 2088
6. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
7. E.M. Brown Is the calcium receptor a molecular target for the actions of strontium on bone? Osteoporos. Int. 14 Suppl. 3 2003 S25 34
8. J. Caverzasio Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms Bone 42 2008 1131 1136
9. A.M. Cortizo, G. Ruderman, G. Correa, I.G. Mogilner, and E.J. Tolosa Effect of surface topography of collagen scaffolds on cytotoxicity and osteoblast differentiation J. Biomater. Tissue Eng. 2012 2
10. N. Chattopadhyay, S.J. Quinn, O. Kifor, C. Ye, and E.M. Brown The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation Biochem. Pharmacol. 74 2007 438 447
11. S. Choudhary, P. Halbout, C. Alander, L. Raisz, and C. Pilbeam Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins J. Bone Miner. Res. 22 2007 1002 1010
12. J.E. Fonseca Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength Rheumatology (Oxford) 47 Suppl. 4 2008 iv17 19
13. S. Franke, C. Ruster, J. Pester, G. Hofmann, P. Oelzner, and G. Wolf Advanced glycation end products affect growth and function of osteoblasts Clin. Exp. Rheumatol. 29 2011 650 660
14. O. Fromigue, E. Hay, A. Barbara, C. Petrel, E. Traiffort, M. Ruat, and P.J. Marie Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate J. Cell. Mol. Med. 13 2009 2189 2199
15. M.V. Gangoiti, A.M. Cortizo, V. Arnol, J.I. Felice, and A.D. McCarthy Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells Eur. J. Pharmacol. 600 2008 140 147
16. J.C. Krakauer, M.J. McKenna, N.F. Buderer, D.S. Rao, F.W. Whitehouse, and A.M. Parfitt Bone loss and bone turnover in diabetes Diabetes 44 1995 775 782
17. S. Kwan Tat, M. Padrines, S. Theoleyre, D. Heymann, and Y. Fortun IL-6, RANKL, TNF-α/IL-1: interrelations in bone resorption pathophysiology Cytokine Growth Factor Rev. 15 2004 49 60
18. U.K. Laemmli, L.A. Amos, and A. Klug Correlation between structural transformation and cleavage of the major head protein of T4 bacteriophage Cell 7 1976 191 203
19. C. Lambert, C. Oury, E. Dejardin, A. Chariot, J. Piette, M. Malaise, M.P. Merville, and N. Franchimont Further insights in the mechanisms of interleukin-1β stimulation of osteoprotegerin in osteoblast-like cells J. Bone Miner. Res. 22 2007 1350 1361
20. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
21. S.C. Manolagas, and A.M. Parfitt What old means to bone Trends Endocrinol. Metab. 21 2010 369 374
22. P.J. Marie Effective doses for strontium ranelate Osteoporos. Int. 19 1813 2008 1815 1817 author reply
23. P.J. Marie Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology Mol. Interv. 10 2010 305 312
24. A.D. McCarthy, S.B. Etcheverry, L. Bruzzone, and A.M. Cortizo Effects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells Mol. Cell. Biochem. 170 1997 43 51
25. A.D. McCarthy, S.B. Etcheverry, L. Bruzzone, G. Lettieri, D.A. Barrio, and A.M. Cortizo Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress BMC Cell Biol. 2 2001 16
26. A.D. McCarthy, S.B. Etcheverry, and A.M. Cortizo Advanced glycation endproduct-specific receptors in rat and mouse osteoblast-like cells: regulation with stages of differentiation Acta Diabetol. 36 1999 45 52
27. A.D. McCarthy, S.B. Etcheverry, and A.M. Cortizo Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development Acta Diabetol. 38 2001 113 122
28. N. Mercer, H. Ahmed, A.D. McCarthy, S.B. Etcheverry, G.R. Vasta, and A.M. Cortizo AGE-R3/galectin-3 expression in osteoblast-like cells: regulation by AGEs Mol. Cell. Biochem. 266 2004 17 24
29. M.S. Molinuevo, L. Schurman, A.D. McCarthy, A.M. Cortizo, M.J. Tolosa, M.V. Gangoiti, V. Arnol, and C. Sedlinsky Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies J. Bone Miner. Res. 25 2010 211 221
30. J.A. Mosquera Role of the receptor for advanced glycation end products (RAGE) in inflammation Invest. Clin. 51 2010 257 268
31. L.D. Quarles, D.A. Yohay, L.W. Lever, R. Caton, and R.J. Wenstrup Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development J. Bone Miner. Res. 7 1992 683 692
32. G. Schett Effects of inflammatory and anti-inflammatory cytokines on the bone Eur. J. Clin. Invest. 41 2011 1361 1366
33. L. Schurman, A.D. McCarthy, C. Sedlinsky, M.V. Gangoiti, V. Arnol, L. Bruzzone, and A.M. Cortizo Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells Exp. Clin. Endocrinol. Diabetes 116 2008 333 340
34. M. Takagi, S. Kasayama, T. Yamamoto, T. Motomura, K. Hashimoto, H. Yamamoto, B. Sato, S. Okada, and T. Kishimoto Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells J. Bone Miner. Res. 12 1997 439 446
35. P. Vestergaard, L. Rejnmark, and L. Mosekilde Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk Diabetologia 48 2005 1292 1299
36. H. Vlassara, and M.R. Palace Diabetes and advanced glycation endproducts J. Intern. Med. 251 2002 87 101
37. H. Vlassara, and G.E. Striker AGE restriction in diabetes mellitus: a paradigm shift Nat. Rev. Endocrinol. 7 2011 526 539
38. K. Wongdee, and N. Charoenphandhu Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms World J. Diabetes 2 2011 41 48
39. L.L. Zhu, S. Zaidi, Y. Peng, H. Zhou, B.S. Moonga, A. Blesius, I. Dupin-Roger, M. Zaidi, and L. Sun Induction of a program gene expression during osteoblast differentiation with strontium ranelate Biochem. Biophys. Res. Commun. 355 2007 307 311