Distinctive Subdomains in the Resorbing Surface of Osteoclasts

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Szewczyk, Kinga A ^a   Fuller, Karen ^a   Chambers, Tim J ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CATHEPSIN K; CELL PROTEIN; CIC 7 PROTEIN; F ACTIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MINERAL; CELL ACTIVATION; CELL MEMBRANE; CELL STRUCTURE; CELL SURFACE; CELL VACUOLE; CELLULAR DISTRIBUTION; ENZYME RELEASE; LIGAND BINDING; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; POLAR BODY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTON TRANSPORT; TRANSMISSION ELECTRON MICROSCOPY;

ACTIN CYTOSKELETON; ACTINS; BONE RESORPTION; CHLORIDE CHANNELS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; OSTEOCLASTS; VACUOLAR PROTON-TRANSLOCATING ATPASES; VITRONECTIN;

EID: 84875360347     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060285     Document Type: Article

References (29)

1. Chambers TJ, (2000) Regulation of the differentiation and function of osteoclasts. J Pathol 192: 4-13.
2. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, et al. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357.
3. Vaananen HK, Zhao H, Mulari M, Halleen JM, (2000) The cell biology of osteoclast function. J Cell Sci 113 (Pt 3): 377-381.
4. Stenbeck G, (2002) Formation and function of the ruffled border in osteoclasts. Semin Cell Dev Biol 13: 285-292.
5. Mulari MT, Zhao H, Lakkakorpi PT, Vaananen HK, (2003) Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake. Traffic 4: 113-125.
6. Fuller K, Ross JL, Szewczyk KA, Moss R, Chambers TJ (2010) Bone is not essential for osteoclast activation. PLoS One 5.
7. Laitala T, Vaananen HK, (1994) Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J Clin Invest 93: 2311-2318.
8. Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T, (2011) ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity. EMBO J 30: 2140-2152.
9. Li YP, Chen W, Liang Y, Li E, Stashenko P, (1999) Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet 23: 447-451.
10. Frattini A, Orchard PJ, Sobacchi C, Giliani S, Abinun M, et al. (2000) Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat Genet 25: 343-346.
11. Kornak U, Kasper D, Bosl MR, Kaiser E, Schweizer M, et al. (2001) Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104: 205-215.
12. Saftig P, Hunziker E, Wehmeyer O, Jones S, Boyde A, et al. (1998) Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A 95: 13453-13458.
13. Kornak U, Schulz A, Friedrich W, Uhlhaas S, Kremens B, et al. (2000) Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis. Hum Mol Genet 9: 2059-2063.
14. Fuller K, Kirstein B, Chambers TJ, (2006) Murine osteoclast formation and function: differential regulation by humoral agents. Endocrinology 147: 1979-1985.
15. McSheehy PM, Chambers TJ, (1986) Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118: 824-828.
16. van Meel E, Boonen M, Zhao H, Oorschot V, Ross FP, et al. (2011) Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis. Traffic 12: 912-924.
17. Holtrop ME, King GJ (1977) The ultrastructure of the osteoclast and its functional implications. Clin Orthop Relat Res: 177-196.
18. Akisaka T, Yoshida H, Suzuki R, (2006) The ruffled border and attachment regions of the apposing membrane of resorbing osteoclasts as visualized from the cytoplasmic face of the membrane. J Electron Microsc (Tokyo) 55: 53-61.
19. Saltel F, Destaing O, Bard F, Eichert D, Jurdic P, (2004) Apatite-mediated actin dynamics in resorbing osteoclasts. Mol Biol Cell 15: 5231-5241.
20. Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, et al. (2007) The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS One 2: e179.
21. Baharloo B, Textor M, Brunette DM, (2005) Substratum roughness alters the growth, area, and focal adhesions of epithelial cells, and their proximity to titanium surfaces. J Biomed Mater Res A 74: 12-22.
22. Grossner-Schreiber B, Herzog M, Hedderich J, Duck A, Hannig M, et al. (2006) Focal adhesion contact formation by fibroblasts cultured on surface-modified dental implants: an in vitro study. Clin Oral Implants Res 17: 736-745.
23. Baron R, Neff L, Louvard D, Courtoy PJ, (1985) Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101: 2210-2222.
24. van Noorden CJ, Everts V, (1991) Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts. Biochem Biophys Res Commun 178: 178-184.
25. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, et al. (2000) The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. Journal of Biological Chemistry 275: 32331-32337.
26. Stenbeck G, Horton MA, (2000) A new specialized cell-matrix interaction in actively resorbing osteoclasts. J Cell Sci 113 (Pt 9): 1577-1587.
27. Bromme D, Okamoto K, Wang BB, Biroc S, (1996) Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J Biol Chem 271: 2126-2132.
28. Chambers TJ, (1985) The pathobiology of the osteoclast. J Clin Pathol 38: 241-252.
29. Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, et al. (2010) Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science 328: 1401-1403.