Topical application of complement C3 in collagen formulation increases early wound healing

Journal of Dermatological Treatment

Volumn 24, Issue 2, 2013, Pages 141-147

  Sinno, Hani ^a   Malholtra, Meenakshi ^a   Lutfy, Justyn ^a   Jardin, Barbara ^a   Winocour, Sebastian ^b   Brimo, Fadi ^b   Beckman, Lorne ^b   Watters, Kevin ^b   Philip, Anie ^b   Williams, Bruce ^a   Prakash, Satya ^a  

^a Faculty of Medicine   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

complement C3; cutaneous; rat; skin; wound healing

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; COMPLEMENT COMPONENT C3; FIBRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG FORMULATION; FIBROBLAST; HISTOPATHOLOGY; INFLAMMATORY CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN; SKIN INCISION; STRENGTH; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; BLOTTING, WESTERN; C-REACTIVE PROTEIN; CELL MOVEMENT; COLLAGEN TYPE I; COMPLEMENT C3; DRUG CARRIERS; FIBROBLASTS; FIBRONECTINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SURGICAL WOUND DEHISCENCE; WOUND HEALING;

EID: 84875353999     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2011.631977     Document Type: Article

References (14)

1. Nguyen DT, Orgill DP, Murphy GF Chapter 4: The pathophysiologic basis for wound healing and cutaneous regeneration. In: Biomaterials for treating skin loss. Cambridge/Boca Raton: Woodhead Publishing (UK/Europe) & CRC Press (US); 2009. p. 25-57.
2. Porras-Reyes BH, Mustoe TA. Platelet-activating factor: improvement in wound healing by a chemotactic factor. Surgery. 1992;111:416-423.
3. Mustoe TA, Purdy J, Gramates P, Deuel TF, Thomason A, Pierce GF. Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg. 1989; 158:345-350. (Pubitemid 19246238)
4. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science. 1987;237:1333-1336. (Pubitemid 17125439)
5. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci. 2004;30:145-151. (Pubitemid 38519799)
6. Powers WE, Ogura JH, Palmer LA. Radiation therapy and wound healing delay. Animals and man. Radiology. 1967;89:112-115.
7. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF. Platelet derived growth factor BB for the treatment of chronic pressure ulcers. Lancet. 1992;339:23-25.
8. Mustoe TA, Cutler NR, Allman RM, Goode PS, Deuel TF, Prause JA, et al. A phase II study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. Arch Surg. 1994;129:213-219. (Pubitemid 24056078)
9. Robson MC, Phillips LG, Thomason A, Altrock BW, Pence PC, Heggers JP, et al. Recombinant human platelet derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plast Surg. 1992;29:193-201.
10. Hugli TE. Biochemistry and biology of anaphylatoxins. Complement. 1986;3:111-127. (Pubitemid 17208216)
11. Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg. 1998;176:26S-38S. (Pubitemid 28460655)
12. Hugli TE, Marceau F, Lundberg C. Effects of complement fragments on pulmonary and vascular smooth muscle. Am Rev Respir Dis. 1987;135:S9-13.
13. Bjork J, Hugli TE, Smedegard G. Microvascular effects of anaphylatoxins C3a and C5a. J Immunol. 1985;134: 1115-1119. (Pubitemid 15157311)
14. Hartung HP, Hadding U. Synthesis of complement by macrophages and modulation of their functions through complement activation. Springer Semin Immunopathol. 1983; 6:283-326. (Pubitemid 14180031)