Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment

Toxicology and Applied Pharmacology

Volumn 268, Issue 3, 2013, Pages 294-299

  Larsen, Søren Thor ^a   Wolkoff, Peder ^a   Hammer, Maria ^a   Kofoed Sørensen, Vivi ^a   Clausen, Per Axel ^a   Nielsen, Gunnar Damgård ^a  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

Author keywords

Airways; Formaldehyde; Humidity; Mice; Sensitization

Indexed keywords

FORMALDEHYDE; OVALBUMIN; SODIUM CHLORIDE;

AEROSOL; AIRBORNE PARTICLE; ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ARTICLE; ASTHMA; BREATHING; BRONCHOSPASM; CONTROLLED STUDY; EXPIRATORY FLOW RATE; EXPOSURE; HUMIDITY; INHALATION; MALE; MOUSE; NONHUMAN; PROVOCATION TEST; RESPIRATORY AIRFLOW; RESPIRATORY TRACT PARAMETERS; SENSITIZATION; SENSORY STIMULATION; SHAM PROCEDURE; UPPER RESPIRATORY TRACT; VAPOR;

AIR POLLUTANTS; ANIMALS; BRONCHITIS; CHICKENS; ENVIRONMENTAL EXPOSURE; FORMALDEHYDE; HUMIDITY; INHALATION EXPOSURE; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; PULMONARY VENTILATION;

EID: 84875347313     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.02.006     Document Type: Article

References (29)

1. Alarie Y. Sensory irritation by airborne chemicals. Crit. Rev. Toxicol. 1973, 2:299-363.
2. Alarie Y. Computer-based bioassay for evaluation of sensory irritation of airborne chemicals and its limit of detection. Arch. Toxicol. 1998, 72:277-282.
3. Boylestein L.A., Anderson S.J., Thompson R.D., Alarie Y. Characterization of the effect of an airborne mixture of chemicals on the respiratory tract and smoothing polynomial spline analysis of the data. Arch. Toxicol. 1995, 69:579-589.
4. Boylestein L.A., Luo J., Stock M.F., Alarie Y. An attempt to define a just detectable effect for airborne chemicals on the respiratory tract in mice. Arch. Toxicol. 1996, 70:567-578.
5. Brewer J.P., Kisselgof A.B., Martin T.R. Genetic variability in pulmonary physiological cellular, and antibody responses to antigen in mice. Am. J. Respir. Crit. Care Med. 1999, 160:1150-1156.
6. Golden R. Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards. Crit. Rev. Toxicol. 2011, 41:672-721.
7. Hansen J.S., Larsen S.T., Poulsen L.K., Nielsen G.D. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice. Toxicology 2007, 232:79-88.
8. Hansen J.S., Larsen S.T., Poulsen L.K., Nielsen G.D. Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization. J. Toxicol. Environ. Health A 2007, 70:128-137.
9. Henderson R.F. Use of bronchoalveolar lavage to detect lung damage. Environ. Health Perspect. 1984, 56:115-129.
10. Larsen S.T., Nielsen G.D. Acute airway irritation of methyl formate in mice. Arch. Toxicol. 2012, 86:285-292.
11. Larsen S.T., Hougaard K.S., Alarie Y., Wolkoff P., Clausen P.A., Wilkins C.K., Nielsen G.D. Effects of R-(+)- and S-(-)-limonene on the respiratory tract in mice. Hum. Exp. Toxicol. 2000, 19:457-466.
12. Larsen S.T., Hansen J.S., Hammer M., Alarie Y., Nielsen G.D. Effects of mono-2-ethylhexyl phthalate on the respiratory tract in BALB/c mice. Hum. Exp. Toxicol. 2004, 23:537-545.
13. Larsen S.T., Matsubara S., McConville G., Poulsen S.S., Gelfand E.W. Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen. J. Toxicol. Environ. Health A 2010, 73:738-747.
14. Li W.L., Pauluhn J. Comparative assessment of the sensory irritation potency in mice and rats nose-only exposed to ammonia in dry and humid atmospheres. Toxicology 2010, 276:135-142.
15. McFadden E.R., Nelson J.A., Skowronski M.E., Lenner K.A. Thermally induced asthma and airway drying. Am. J. Respir. Crit. Care Med. 1999, 160:221-226.
16. Mendell M.J., Mirer A.G., Cheung K., Tong M., Douwes J. Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ. Health Perspect. 2011, 119:748-756.
17. Nielsen G.D., Hougaard K.S., Larsen S.T., Hammer M., Wolkoff P., Clausen P.A., Wilkins C.K., Alarie Y. Acute airway effects of formaldehyde and ozone in BALB/c mice. Hum. Exp. Toxicol. 1999, 18:400-409.
18. Nielsen G.D., Larsen S.T., Hougaard K.S., Hammer M., Wolkoff P., Clausen P.A., Wilkins C.K., Alarie Y. Mechanisms of acute inhalation effects of (+) and (-)-α-pinene in BALB/c mice. Pharmacol. Toxicol. 2005, 96:1-9.
19. Nøjgaard J.K., Christensen K.B., Wolkoff P. The effect on human eye blink frequency by exposure to limonene oxidation products and methacrolein. Toxicol. Lett. 2005, 156:241-251.
20. Raeburn D., Webber S.E. Proinflammatory potential of the airway epithelium in bronchial asthma. Eur. Respir. J. 1994, 7:2226-2233.
21. Sunwoo Y., Chou C., Takeshita J., Murakami M., Tochihara Y. Physiological and subjective responses to low relative humidity in young and elderly men. J. Physiol. Anthropol. 2006, 25:229-238.
22. Taylor-Clark T.E., Undem B.J. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J. Physiol. 2010, 588:423-433.
23. Vijayaraghavan R., Schaper M., Thompson R., Stock M.F., Alarie Y. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch. Toxicol. 1993, 67:478-490.
24. Vijayaraghavan R., Schaper M., Thompson R., Stock M.F., Boylstein L.A., Luo J.E., Alarie Y. Computer assisted recognition and quantitation of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. Arch. Toxicol. 1994, 68:490-499.
25. Wilkins C.K., Wolkoff P., Clausen P.A., Hammer M., Nielsen G.D. Upper airway irritation of terpene/ozone oxidation products (TOPS). Dependence on reaction time, relative humidity and initial ozone concentration. Toxicol. Lett. 2003, 143:109-114.
26. Wolkoff P., Kjærgaard S.K. The dichotomy of relative humidity on indoor air quality. Environ. Int. 2007, 33:850-857.
27. Wolkoff P., Nielsen G.D. Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline. Environ. Int. 2010, 36:788-799.
28. Wolkoff P., Kärcher T., Mayer H. Problems of the "outer eyes" in the office environment: an ophthalmologic approach. J. Occup. Environ. Med. 2012, 54:621-631.
29. World Health Organisation WHO Guidelines for indoor air quality. Selected Pollutants 2010, WHO Regional Office for Europe, Copenhagen.