BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Bai, Jin ^a   Mei, Pengjin ^a   Zhang, Cuipeng ^a   Chen, Feifei ^a   Li, Chen ^a   Pan, Zhenqiang ^a,b   Liu, Hui ^a   Zheng, Junnian ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRG1 PROTEIN; CYCLIN D1; CYCLIN E; GELATINASE A; PROTEIN P27; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; AGED; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CANCER SURVIVAL; CELL CYCLE REGULATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SPECIFIC SURVIVAL; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SURVIVAL RATE; TISSUE MICROARRAY; UPREGULATION;

BREAST NEOPLASMS; CELL CYCLE; CYCLIN D1; CYCLIN E; DNA HELICASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; NUCLEAR PROTEINS; PROGNOSIS; TRANSCRIPTION FACTORS;

EID: 84875343421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059772     Document Type: Article

References (34)

1. DeSantis C, Siegel R, Bandi P, Jemal A, (2011) Breast cancer statistics, 2011. CA Cancer J Clin 61: 409-418.
2. Chen J, Gallo KA, (2012) MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis. Cancer Res 72: 4130-4140.
3. Cowper-Sal Lari R, Zhang X, Wright JB, Bailey SD, Cole MD, et al. (2012) Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat Genet 44: 1191-1198.
4. Ho L, Crabtree GR, (2010) Chromatin remodelling during development. Nature 463: 474-484.
5. Wu JI, (2012) Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer. Acta Biochim Biophys Sin (Shanghai) 44: 54-69.
6. Dinant C, Houtsmuller AB, Vermeulen W, (2008) Chromatin structure and DNA damage repair. Epigenetics Chromatin 1: 9.
7. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, et al. (1996) Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev 10: 2117-2130.
8. Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, et al. (2000) A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell 6: 1287-1295.
9. Reisman D, Glaros S, Thompson EA, (2009) The SWI/SNF complex and cancer. Oncogene 28: 1653-1668.
10. Bock VL, Lyons JG, Huang XX, Jones AM, McDonald LA, et al. (2011) BRM and BRG1 subunits of the SWI/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours. Br J Dermatol 164: 1221-1227.
11. Fukuoka J, Fujii T, Shih JH, Dracheva T, Meerzaman D, et al. (2004) Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res 10: 4314-4324.
12. Wong AK, Shanahan F, Chen Y, Lian L, Ha P, et al. (2000) BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res 60: 6171-6177.
13. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E, (1999) Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol Cell Biol 19: 1460-1469.
14. Muchardt C, Yaniv M, (2001) When the SWI/SNF complex remodels..the cell cycle. Oncogene 20: 3067-3075.
15. Bai J, Mei PJ, Liu H, Li C, Li W, et al. (2012) BRG1 expression is increased in human glioma and controls glioma cell proliferation, migration and invasion in vitro. J Cancer Res Clin Oncol 138: 991-998.
16. Lin H, Wong RP, Martinka M, Li G, (2010) BRG1 expression is increased in human cutaneous melanoma. Br J Dermatol 163: 502-510.
17. Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ, (2009) The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene 28: 2492-2501.
18. Sentani K, Oue N, Kondo H, Kuraoka K, Motoshita J, et al. (2001) Increased expression but not genetic alteration of BRG1, a component of the SWI/SNF complex, is associated with the advanced stage of human gastric carcinomas. Pathobiology 69: 315-320.
19. Sun A, Tawfik O, Gayed B, Thrasher JB, Hoestje S, et al. (2007) Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers. Prostate 67: 203-213.
20. Elston CW, Ellis IO, (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-410.
21. Remmele W, Stegner HE, (1987) [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]. Pathologe 8: 138-140.
22. Mei PJ, Bai J, Liu H, Li C, Wu YP, et al. (2011) RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. J Cancer Res Clin Oncol 137: 1823-1830.
23. Serber DW, Rogala A, Makarem M, Rosson GB, Simin K, et al. (2012) The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. PLoS One 7: e31346.
24. DelBove J, Rosson G, Strobeck M, Chen J, Archer TK, et al. (2011) Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene. Epigenetics 6: 1444-1453.
25. Dal Molin M, Hong SM, Hebbar S, Sharma R, Scrimieri F, et al. (2012) Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas. Hum Pathol 43: 585-591.
26. Watanabe T, Semba S, Yokozaki H, (2011) Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells. Br J Cancer 104: 146-154.
27. Rodriguez-Nieto S, Sanchez-Cespedes M, (2009) BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer. Carcinogenesis 30: 547-554.
28. Zhang B, Chambers KJ, Leprince D, Faller DV, Wang S, (2009) Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control. Oncogene 28: 651-661.
29. Hendricks KB, Shanahan F, Lees E, (2004) Role for BRG1 in cell cycle control and tumor suppression. Mol Cell Biol 24: 362-376.
30. Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, et al. (2000) BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 102: 257-265.
31. Keenen B, Qi H, Saladi SV, Yeung M, de la Serna IL, (2010) Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene 29: 81-92.
32. Deryugina EI, Quigley JP, (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34.
33. Zhou Y, Yu C, Miao X, Tan W, Liang G, et al. (2004) Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. Carcinogenesis 25: 399-404.
34. Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, et al. (2010) Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer 9: 280.