Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation

Heart Rhythm

Volumn 10, Issue 3, 2013, Pages 383-391

  Yeh, Yung Hsin ^a   Kuo, Chi Tai ^a   Lee, Yun Shien ^b   Lin, Yuan Min ^c   Nattel, Stanley ^d   Tsai, Feng Chun ^a   Chen, Wei Jan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b MING CHUAN UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Atrial fibrillation; Fibrosis; Left atrium; Microarray

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALKALINE PHOSPHATASE; ALPHA2 GLYCOPROTEIN; AMPHIREGULIN; BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 6; CERULOPLASMIN; CHORIONIC GONADOTROPIN; CLAUDIN 1; HYPOCALCIN; INTERLEUKIN 7; INTESTINAL TREFOIL FACTOR; PROTEIN KINASE B; SCLEROSTIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR FOXC1; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR PITX2; TROPOMYOSIN; VITRONECTIN;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CARDITIS; CELL DEATH; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEART ARRHYTHMIA; HEART ATRIUM APPENDAGE; HEART ATRIUM FIBRILLATION; HEART HYPERTROPHY; HEART LEFT ATRIUM; HEART MUSCLE FIBROSIS; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINUS RHYTHM; UPREGULATION;

ADULT; AGED; ATRIAL APPENDAGE; ATRIAL FIBRILLATION; ATRIAL FUNCTION, LEFT; BLOTTING, WESTERN; CARDIAC SURGICAL PROCEDURES; FEMALE; GENE EXPRESSION REGULATION; HEART VALVE DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MUSCLE PROTEINS; POLYMERASE CHAIN REACTION; RNA; TISSUE ARRAY ANALYSIS; TRANSCRIPTOME;

EID: 84875308967     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.11.013     Document Type: Article

References (35)

1. R. Wakili, N. Voigt, S. Kaab, D. Dobrev, and S. Nattel Recent advances in the molecular pathophysiology of atrial fibrillation J Clin Invest 121 2011 2955 2968
2. U. Schotten, S. Verheule, P. Kirchhof, and A. Goette Pathophysiological mechanisms of atrial fibrillation: a translational appraisal Physiol Rev 91 2011 265 325
3. P.C. Kahr, I. Piccini, and L. Fabritz Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue PLoS One 6 2011 e26389
4. R. Kabra, and J.P. Singh Catheter ablation targeting complex fractionated atrial electrograms for the control of atrial fibrillation Curr Opin Cardiol 27 2012 49 54
5. P. Sanders, O. Berenfeld, and M. Hocini Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans Circulation 112 2005 789 797
6. K. Nademanee, J. McKenzie, and E. Kosar A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate J Am Coll Cardiol 43 2004 2044 2053
7. M. Haissaguerre, M. Wright, M. Hocini, and P. Jais The substrate maintaining persistent atrial fibrillation Circ Arrhythm Elec 1 2008 2 5
8. Y.J. Lin, C.T. Tai, and T. Kao Spatiotemporal organization of the left atrial substrate after circumferential pulmonary vein isolation of atrial fibrillation Circ Arrhythm Elec 2 2009 233 241
9. 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation Circulation 125 2012 2059 2070
10. M.F. Swartz, G.W. Fink, and C.J. Lutz Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery Heart Rhythm 6 2009 1415 1422
11. N. Voigt, A. Trausch, and M. Knaut Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation Circ Arrhythm Elec 3 2010 472 480
12. D. Franco, M. Campione, and R. Kelly Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart Cir Res 87 2000 984 991
13. K. Ohara, H. Inoue, and T. Nozawa Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation Int J Cardiol 126 2008 316 321
14. H. Inoue, T. Nozawa, K. Okumura, J.D. Lee, A. Shimizu, and K. Yano Prothrombotic activity is increased in patients with nonvalvular atrial fibrillation and risk factors for embolism Chest 126 2004 687 692
15. I.R. Goldsmith, A.D. Blann, R.L. Patel, and G.Y. Lip von Willebrand factor, fibrinogen, and soluble P-selectin levels after mitral valve replacement versus mitral valve repair Am J Cardiol 85 2000 1218 1222
16. T. Watson, E. Shantsila, and G.Y. Lip Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited Lancet 373 2009 155 166
17. W.J. Chen, Y.H. Yeh, K.H. Lin, G.J. Chang, and C.T. Kuo Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism Basic Res Cardiol 106 2011 163 174
18. Y.H. Yeh, C.T. Kuo, and T.H. Chan Transforming growth factor-beta and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes Cardiovasc Res 91 2011 62 70
19. J. Wang, E. Klysik, S. Sood, R.L. Johnson, X. Wehrens, and J.F. Martin Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification Proc Natl Acad Sci USA 107 2010 9753 9758
20. N.G. Frangogiannis Matricellular proteins in cardiac adaptation and disease Physiol Rev 92 2012 635 688
21. A. Raya, and J.C. Izpisura Belmonte Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration Nat Rev Genet 7 2006 283 293
22. D.F. Gudbjartsson, D.O. Arnar, and A. Helgadottir Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 448 2007 353 357
23. S. Kaab, D. Darbar, and C. van Noord Large-scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation Eur Heart J 30 2009 813 819
24. P. Kirchhof, P.C. Kahr, and S. Kaese PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression Circ Cardiovasc Genet 4 2011 123 133
25. A Chinchilla, H Daimi, and E Lozano-Velasco PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis Circ Cardiovasc Genet 4 2011 269 279
26. R.A. Espinoza-Lewis, H. Liu, C. Sun, C. Chen, K. Jiao, and Y.P. Chen Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice Dev Biol 356 2011 359 369
27. B.L. Nguyen, M.C. Fishbein, L.S. Chen, P.S. Chen, and S. Masroor Histopathological substrate for chronic atrial fibrillation in humans Heart Rhythm 6 2009 454 460
28. G. Sweeney Cardiovascular effects of leptin Nat Rev Cardiol 7 2010 22 29
29. O. Yasuda, Y. Takemura, H. Kawamoto, and H. Rakugi Aspirin: recent developments Cell Mol Life Sci 65 2008 34 38
30. C.J. Fang, A. Richards, M.K. Liszewski, D. Kavanagh, and J.P. Atkinson Advances in understanding of pathogenesis of aHUS and HELLP Br J Haematol 143 2008 336 348
31. D. Dobrev Is altered atrial microRNA-ome a critical contributor to the pathophysiology of atrial fibrillation? Basic Res Cardiol 107 2012 284
32. D. Corradi, S. Callegari, and S. Benussi Myocyte changes and their left atrial distribution in patients with chronic atrial fibrillation related to mitral valve disease Hum Pathol 36 2005 1080 1089
33. D. Corradi, S. Callegari, and R. Maestri Heme oxygenase-1 expression in the left atrial myocardium of patients with chronic atrial fibrillation related to mitral valve disease: its regional relationship with structural remodeling Hum Pathol 39 2008 1162 1171
34. N. Gaborit, M. Steenman, and G. Lamirault Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation Circulation 112 2005 471 481
35. D. Dobrev, L. Carlsson, and S. Nattel Novel molecular targets for atrial fibrillation therapy Nat Rev Drug Discov 11 2012 275 291