A randomized, double-blind, placebo-controlled trial of oral montelukast in acute asthma exacerbation

BMC Pulmonary Medicine

Volumn 13, Issue 1, 2013, Pages

  Zubairi, Ali Bin Sarwar ^a   Salahuddin, Nawal ^a   Khawaja, Ali ^a   Awan, Safia ^a   Shah, Adil Aijaz ^a   Haque, Ahmed Suleman ^a   Husain, Shahid Javed ^a   Rao, Nisar ^a   Khan, Javaid Ahmad ^a  

^a AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

Asthma attack; FEV1; Leukotriene receptor antagonist; Montelukast; PEF

Indexed keywords

HYDROCORTISONE; IPRATROPIUM BROMIDE; MONTELUKAST; PREDNISOLONE; SALBUTAMOL; ACETIC ACID DERIVATIVE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PLACEBO; QUINOLINE DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; ACUTE DISEASE; AGED; CONVALESCENCE; DRUG EFFECTS; FORCED EXPIRATORY VOLUME; IMMUNOLOGY; LUNG; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PEAK EXPIRATORY FLOW; PHYSIOLOGY; TREATMENT OUTCOME;

ACETATES; ACUTE DISEASE; ADMINISTRATION, ORAL; ADULT; AGED; ASTHMA; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOTRIENE ANTAGONISTS; LUNG; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; PLACEBOS; QUINOLINES; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 84875306673     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-13-20     Document Type: Article

References (26)

1. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for asthma: United States, 1980-1999. MMWR CDC Surveill Summ 2002, 51:1-13.
2. Hazir T, Das C, Piracha F, Waheed B, Azam MI. Carers' perception of childhood asthma and its management in a selected Pakistani community. Arch Dis Chil 2002, 87:287-290.
3. Khan MA, Hazir T. Management of bronchial asthma in children. J Pak Med Assoc 1995, 45:46-50.
4. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H,. ISAAC Phase Three Study Group Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet 2006, 368:733-743. ISAAC Phase Three Study Group.
5. Peters-Golden M, Henderson WR. Leukotrienes. N Engl J Med 2007, 357:1841-1854.
6. Dockhorn RJ, Baumgartner RA, Leff JA, Noonan M, Vandormael K, Stricker W, Weinland DE, Reiss TF. Comparison of the effects of intravenous and oral montelukast on airway function: a double blind, placebo controlled, three period, crossover study in asthmatic patients. Thorax 2000, 55:260-265.
7. Global Initiative for Asthma Global Strategy for Asthma Management and Prevention. Updated 2010 http://www.ginasthma.org/Guidelines/guidelines-resources.html, Global Initiative for Asthma.
8. Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev 2001, 1. CD002178.
9. Strauss L, Hejal R, Galan G, Dixon L, McFadden ER. Observations on the effects of aerosolized albuterol in acute asthma. Am J Respir Crit Care Med 1997, 155:454-458.
10. National Asthma Education and Prevention Program Expert panel report II: guidelines for the diagnosis and management of asthma 1997, Bethesda, MD: National Heart, Lung and Blood Institute, NIH Publication No. 97-4051, National Asthma Education and Prevention Program.
11. National Institutes of Health Global initiative for asthma: global strategy for asthma management and prevention: National Heart, Lung, and Blood Institute/World Health Organization Workshop Report 1995, Bethesda, MD: National Institutes of Health, NIH Publication No. 95-3659, National Institutes of Health.
12. Kelsen SG, Kelsen DP, Fleeger BF, Jones RC, Rodman T. Emergency room assessment and treatment of patients with acute asthma: adequacy of the conventional approach. Am J Med 1978, 64:622-628.
13. Ducharme FM, Kramer MS. Relapse following emergency treatment for acute asthma: can it be predicted or prevented?. J Clin Epidemiol 1993, 46:1395-1402.
14. Emerman CL, Cydulka RK. Factors associated with relapse after emergency department treatment for acute asthma. Ann Emerg Med 1995, 26:6-11.
15. Emerman CL, Woodruff PG, Cydulka RK, Gibbs MA, Pollack CV, Camargo CA. Prospective multicenter study of relapse following treatment for acute asthma among adults presenting to the emergency department. MARC investigators. Multicenter asthma research collaboration. Chest 1999, 115:919-927.
16. Malmstrom K, Rodriguez-Gomez G, Guerra J, Villaran C, Piñeiro A, Wei LX, Seidenberg BC, Reiss TF. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/beclomethasone study group. Ann Intern Med 1999, 130(6):487-495.
17. Arm JP, Lee TH. Chemical mediators: Leukotrienes and eicosanoids. Bronchial asthma: mechanisms and therapeutics 1993, 112-134. Boston: Little Brown, Weiss EB, Stein M.
18. Ramsay CF, Pearson D, Mildenhall S, Wilson AM. Oral montelukast in acute asthma exacerbations: a randomized, double-blind, placebo-controlled trial. Thorax 2011, 66:7-11.
19. Silverman RA, Nowak RM, Korenblat PE, Skobeloff E, Chen Y, Bonuccelli CM, Miller CJ, Simonson SG. Zafirlukast treatment for acute asthma: evaluation in a randomised, double-blind, multicenter trial. Chest 2004, 126:1480-1489.
20. Camargo CA, Smithline HA, Malice MP, Green SA, Reiss TF. A randomized controlled trial of intravenous montelukast in acute asthma. Am J Respir Crit Care Med 2003, 167:528-533.
21. Adachi M, Taniguchi H, Tohda Y, Sano Y, Ishine T, Smugar SS, Hisada S. The efficacy and tolerability of intravenous montelukast in acute asthma exacerbations in Japanese patients. J Asthma 2012, 49:649-656.
22. Nelson KA, Smith SR, Trinkaus K, Jaffe DM. Pilot study of oral montelukast added to standard therapy for acute asthma exacerbations in children aged 6 to 14 years. Pediatr Emerg Care 2008, 24:21-27.
23. Morris CR, Becker AB, Piñieiro A, Massaad R, Green SA, Smugar SS, Gurner DM. A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma. Ann Allergy Asthma Immunol 2010, 104:161-171.
24. Todi VK, Lodha R, Kabra SK. Effect of addition of single dose of oral montelukast to standard treatment in acute moderate to severe asthma in children between 5 and 15 years of age: a randomised, double-blind, placebo controlled trial. Arch Dis Child 2010, 95:540-543.
25. Green SA, Malice MP, Tanaka W, Tozzi CA, Reiss TF. Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation. Thorax 2004, 59:100-104.
26. Rothe T, Karrer W, Schindler C. Accuracy of the piko-1 pocket spirometer. J Asthma 2012, 49:45-50.