Postural Tachycardia Syndrome in Children and Adolescents

Seminars in Pediatric Neurology

Volumn 20, Issue 1, 2013, Pages 18-26

  Jarjour, Imad T ^a,b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CLONIDINE; DESMOPRESSIN; FLUDROCORTISONE; IMMUNOGLOBULIN; METHYLPHENIDATE; METOPROLOL; MIDODRINE; OCTREOTIDE; PHENOTHIAZINE DERIVATIVE; PROPRANOLOL; PYRIDOSTIGMINE; RECOMBINANT ERYTHROPOIETIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE;

ABDOMINAL CRAMP; ARTICLE; AUTONOMIC NEUROPATHY; CLINICAL FEATURE; COMPRESSION STOCKING; DIARRHEA; DISEASE CLASSIFICATION; DRUG DOSE TITRATION; EXERCISE; FLUID INTAKE; HUMAN; HYPOVOLEMIA; JOINT LAXITY; LOW DRUG DOSE; ORTHOSTATIC HYPOTENSION; ORTHOSTATIC INTOLERANCE; PARESTHESIA; PATHOPHYSIOLOGY; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; PRACTICE GUIDELINE; PREVALENCE; PRURITUS; SALT INTAKE; SCALP PRURITUS; SYMPTOMATOLOGY; VENOUS STASIS;

ADOLESCENT; CHILD; HUMANS; ORTHOSTATIC INTOLERANCE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME;

EID: 84875275758     PISSN: 10719091     EISSN: 15580776     Source Type: Journal    
DOI: 10.1016/j.spen.2013.01.001     Document Type: Article

References (71)

1. Low P.A., Sandroni P., Joyner M., et al. Postural tachycardia syndrome (POTS). J Cardiovasc Electrophysiol 2009, 20:352-358.
2. Stewart J.M. Orthostatic intolerance in pediatrics. J Pediatr 2002, 140:404-411.
3. Schondrof R., Low P.A. Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?. Neurology 1993, 43:132-137.
4. Mathias C.J., Low P.A., Iodice V., et al. Postural tachycardia syndrome-current experience and concepts. Nat Rev Neurol 2012, 8:22-34.
5. Yamaguchi H., Tanaka H., Adachi K., et al. Beat-to-beat blood pressure and heart rate responses to active standing in Japanese children. Acta Paediatr 1996, 85:577-583.
6. Weiling W., Karemaker J.M. Measurement of heart rate and blood pressure to evaluate disturbances in neurocardiovascular control. Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System 2006, 196-210. Oxford University Press, Oxford. ed 4. C.J. Mathias, R. Bannister (Eds.).
7. Horam W.J., Roscelli J.D. Establishing standards of orthostatic measurements in normovolemic adolescents. Am J Dis Child 1992, 146:848-851.
8. Skinner J.E., Driscoll S.W., Porter C.B., et al. Orthostatic heart rate and blood pressure in adolescents: Reference ranges. J Child Neurol 2010, 25:1210-1215.
9. Singer W., Sletten D.M., Opfer-Gehrking T.L., et al. Postural tachycardia in children and adolescents: What is abnormal?. J Pediatr 2012, 160:222-226.
10. Thieben M.J., Sandroni P., Sletten D.M., et al. Postural orthostatic tachycardia syndrome: The Mayo Clinic experience. Mayo Clin Proc 2007, 82:308-313.
11. Ojha A., Chelimsky T.C., Chelimsky G. Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome. J Pediatr 2011, 158:20-23.
12. Streeten D.H., Kerr C.B., Kerr L.P., et al. Hyperbradykininism: A new orthostatic syndrome. Lancet 1972, 7786:1048-1053.
13. Stewart J.M., Gewitz M.H., Weldon A., et al. Patterns of orthostatic intolerance: The orthostatic tachycardia syndrome and adolescent chronic fatigue. J Pediatr 1999, 135:218-225.
14. Tanka H., Yamaguchi H., Matushima R., et al. Instantaneous orthostatic hypotension in children and adolescents: A new entity of orthostatic intolerance. Pediatr Res 1999, 46:691-696.
15. Karas B., Grubb B.P., Boehm K., et al. The postural orthostatic tachycardia syndrome: A potentially treatable cause of chronic fatigue, exercise intolerance, and cognitive impairment in adolescents. Pacing Clin Electrophysiol 2000, 23:344-351.
16. Stewart J.M. Transient orthostatic hypotension is common in adolescents. J Pediatr 2002, 140:418-424.
17. Robertson D. The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 2008, 18(suppl 1):2-7.
18. Weiling W., van Lieshout J.J. Maintenance of postural normotension in humans. Clinical Autonomic Disorders 2008, 57-67. ed 3. P.A. Low, E.E. Benarroch (Eds.).
19. Wieling W., Krediet C.T.P., van Dijk N., et al. Initial orthostatic hypotension: Review of a forgotten condition. Clin Sci 2007, 112:157-165.
20. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 46:1470, 1996.
21. Freeman R., Wieling W., Axelrod F.B., et al. Consensus statement on the definition of orthostatic hypotension, neutrally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 2011, 21:69-72.
22. Gibbons C.H., Freeman R. Delayed orthostatic hypotension a frequent cause of orthostatic intolerance. Neurology 2006, 67:28-32.
23. Vernino S., Low P.A., Fealey R.D., et al. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med 2000, 343:847-855.
24. Stewart J.M. Postural tachycardia syndrome and reflex syncope: Similarities and differences. J Pediatr 2009, 154:481-485.
25. Jarjour I.T., Jarjour L.K. Low iron storage in children and adolescents with neutrally mediated syncope. J Pediatr 2008, 153:40-44.
26. Hernandez A., Jarjour I.T., Jarjour L.K. Pediatric postural tachycardia syndrome. A children's hospital experience. Neurology 2012, 78(suppl 1). [P05.205 (Abstract)], 2012.
27. Khurana R.K., Eisenberg L. Orthostatic and non-orthostatic headache in postural tachycardia. Cephalalgia 2011, 31:409-415.
28. Mack K.J., Johnson J.N., Rowe P. Orthostatic intolerance and the headache patient. Semin Pediatr Neurol 2010, 17:109-116.
29. Chelmisky G., Boyle J.T., Tusing L., et al. Autonomic abnormalities in children with functional abdominal pain: Coincidence or etiology?. J Pediatr Gastroenterol Nutr 2001, 33:47-53.
30. Ocon A.J., Messer Z.R., Medow M.S., et al. Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome. Clin Sci 2012, 122:227-238.
31. Galland B.C., Jackson P.M., Sayers R.M., et al. A matched case control study of orthostatic intolerance in children/adolescents with chronic fatigue syndrome. Pediatr Res 2008, 63:196-202.
32. Bagai K., Song Y., Ling J.F., et al. Sleep disturbances and diminished quality of life in postural tachycardia syndrome. J Clin Sleep Med 2011, 7:204-210.
33. Raj V., Haman K.L., Raj S.R., et al. Psychiatric profile and attention deficits in postural tachycardia syndrome. J Neurol Neurosurg Psychiatry 2009, 80:339-344.
34. Benrud-Larson L.M., Sandroni P., Haythornthwaite J.A., et al. Correlates of functional disability in patients with postural tachycardia syndrome: Preliminary cross-sectional findings. Health Psychol 2003, 22:643-648.
35. Kanjwal K., Saeed B., Karabin B., et al. Clinical presentation and management of patients with hyperadrenergic postural orthostatic tachycardia syndrome. A single center experience. Cardiol J 2011, 18:527-531.
36. Garland E.M., Raja S.R., Black B.K., et al. The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome. Neurology 2007, 69:790-798.
37. Robertson D. The epidemic of orthostatic tachycardia and orthostatic intolerance. Am J Med Sci 1999, 317:75-77.
38. Shannon J.R., Flattem N.L., Jordan J., et al. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 2000, 342:541-549.
39. Lenders J.W., Eisenhofer G., Mannelli M., et al. Pheochromocytoma. Lancet 2005, 366:665-675.
40. Shibao C., Arzubiaga C., Roberts L.J., et al. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension 2005, 45:385-390.
41. Ketch T., Biaggioni I., Robertson R., et al. Four faces of baroreflex failure hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia. Circulation 2002, 105:2518-2523.
42. Stewart J.M., Weldon A. Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. J Appl Physiol 2000, 89:1505-1512.
43. Masuki S., Eisenach J.H., Johnson C.P., et al. Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety. J Appl Physiol 2007, 102:896-903.
44. Stewart J.M. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res 2000, 48:218-226.
45. Tanaka H., Matsushima R., Tamai H., et al. Impaired postural cerebral hemodynamics in young patients with chronic fatigue with or without orthostatic intolerance. J Pediatr 2002, 140:142-147.
46. Freeman R. The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes. Clin Auton Res 2002, 12:231-233.
47. Okamoto L.E., Raja S.R., Peltier A., et al. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. Clin Sci 2012, 122:183-192.
48. Jarjour I.T., Jarjour L.K. The diagnostic value of co-morbid conditions in neutrally mediated syncope. Ann Neurol 2006, 60(suppl 3):S147. [Abstract].
49. Jarjour I.T., Jarjour L.K. Low iron stores in postural tachycardia syndrome in adolescents. Clin Auton Res 2009, 19:277. [Abstract].
50. Jarjour I.T., Jarjour L.K. Hypovitaminosis D in postural tachycardia syndrome in adolescents. Ann Neurol 2009, 66(suppl 13):S129. [Abstract].
51. Antiel R.M., Caudill J.S., Bukhardt B.E., et al. Iron Insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance. South Med J 2012, 104:609-611.
52. Jacob G., Costa F., Shannon J.R., et al. The neuropathic postural tachycardia syndrome. N Engl J Med 2000, 343:1008-1014.
53. Mckeon A., Lennon V.A., Lachance D.H., et al. Ganglionic acetylcholine receptor autoantibody. Arch Neurol 2009, 66:735-741.
54. Murali H.R., Mack K.J., Kuntz N.L. Acquired orthostatic intolerance and alpha-3 ganglionic acetylcholine antibodies in an adolescent girl. Clin Auton Res 2009, 19:298. [Abstract].
55. Rowe P.C., Barron D.F., Calkins H., et al. Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome. J Pediatr 1999, 135:494-499.
56. Gazit Y., Nahrin A.M., Grahame R., et al. Dysautonomia in the joint hypermobility syndrome. Am J Med 2003, 115:33-40.
57. Smits-Engelsman B., Klerks M., Kirby A. Beighton score: A valid measure for generalized hypermobility in children. J Pediatr 2011, 158:119-123.
58. Brady P.A., Low P.A., Shen W.K. Inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, and overlapping syndromes. Pacing Clin Electrophysiol 2005, 28:1112-1121.
59. Al-Shekhlee A., Lindenberg J.R., Hachwi R., et al. The value of autonomic testing in postural tachycardia syndrome. Clin Auton Res 2005, 15:219-222.
60. Sukul D., Chelimsky T.C., Chelimsky G. Pediatric autonomic testing: Retrospective review of a large series. Clin Pediatr 2012, 51:17-22.
61. Brewster J.A., Garland E.M., Biaggioni I., et al. Diurnal variability in orthostatic tachycardia: Implications for the postural tachycardia syndrome. Clin Sci 2012, 122:25-31.
62. Low P.A., Schondorf R., Rummans T.A. Why do patients have orthostatic symptoms in POTS?. Clin Auton Res 2001, 11:223-224.
63. El-Sayed R. Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart 1996, 75:134-140.
64. Shannon J.R., Diedrich A., Biaggioni I., et al. Water drinking as a treatment for orthostatic syndromes. Am J Med 2002, 112:355-360.
65. Fu Q., Vangundy T.B., Shibata S., et al. Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome. Hypertension 2011, 58:167-175.
66. Verdon F., Burnand B., Stubi C.L., et al. Iron supplementation for unexplained fatigue in non-anaemic women: Double blind randomised placebo controlled trial. Br Med J 2003, 326:1124-1127.
67. Fortunato J.E., Shaltout H.A., Larkin M.M., et al. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clin Auton Res 2001, 21:419-423.
68. Gordon V.M., Opfer-Gehrking T.L., Novak V., et al. Hemodynamic and symptomatic effects of acute interventions on tilt in patients with postural tachycardia syndrome. Clin Auton Res 2000, 10:29-33.
69. Chen L., Wang L., Sun J., et al. Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome. Circ J 2011, 75:927-931.
70. Raj S.R., Black B.K., Biaggioni I., et al. Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome. Circulation 2005, 111:2734-2740.
71. Iodice V., Kimpinski K., Vernino S., et al. Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopathy. Neurology 2009, 72:2002-2008.