Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 2, 2013, Pages 516-523

  Sawant, Devendra A ^a   Tharakan, Binu ^a   Tobin, Richard P ^a   Reilly, John ^a   Hunter, Felicia A ^a   Newell, Martha Karen ^a   Smythe, William Roy ^a   Childs, Ed W ^b  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial adherens junctions; Hemorrhagic shock; Mitochondria; Vascular leak

Indexed keywords

BETA CATENIN; CASPASE 3; DIHYDRORHODAMINE 123; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MITOCHONDRIAL CREATINE KINASE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; STAUROSPORINE; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUOROMETRY; IMMUNOFLUORESCENCE; MEMBRANE POTENTIAL; MICROVASCULAR ENDOTHELIAL CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ADHERENS JUNCTIONS; ANIMALS; CAPILLARY PERMEABILITY; CASPASE 3; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FLOW CYTOMETRY; MICROSCOPY, FLUORESCENCE; MICROVESSELS; MITOCHONDRIA; RATS; REACTIVE OXYGEN SPECIES; STAUROSPORINE;

EID: 84875259004     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31827a0620     Document Type: Article

References (28)

1. Childs EW, Udobi KF, Hunter FA, Dhevan V. Evidence of transcellular albumin transport after hemorrhagic shock. Shock. 2005;23:565-570.
2. Yuan SY. Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol. 2002;39:213-223.
3. Gibran HS, Heimbach DM. Current status of burn wound pathophysiology. Clin Plast Surg. 2000;27:11-22.
4. Dejana E, Spagnuolo R, Bazzoni G. Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb Haemost. 2001;86:308-315.
5. Dejana E, Orsenigo F, Lampugnani MG. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci. 2008;121:2115-2122.
6. Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Investig Dermatol. 2007;127:2525-2532.
7. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2008;84:869-901.
8. Sawant DA, Tharakan B, Hunter FA, Smythe WR, Childs EW. Role of A-catenin in regulating microvascular endothelial cell hyperpermeability. J Trauma. 2011;70:481-487.
9. Sawant DA, Tharakan B, Adekanbi A, Hunter FA, Smythe WR, Childs EW. Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability. Microcirculation. 2011;18:46-55.
10. Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2007;292:H3179-H3189.
11. Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyper-permeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2008;294:H2285-H2295.
12. Steinhusen U, Badock V, Baur A, Behrens J, Wittman-Liebold B, Dorken B, Bommert K. Apoptosis-induced Cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem. 2000;275:16345-16353.
13. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun. 2003;304:433-435.
14. Sugawara T, Noshita N, Lewen A, Gasche Y, Ferrand-Drake M, Fujimura M, Morita-Fujimura Y, Chan PH. Overexpression of copper/zinc super-oxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci. 2002;22:209-217.
15. Garrido C, Galluzi L, Brunet M, Puig PE, Didelot C, Kroemer G. Mechanism of cytochrome c release from mitochondria. Cell Death Diff. 2006;13:1423-1433.
16. Gregorc U, Ivanova S, Thomas M, Turk V, Banks L, Turk B. hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis. Biol Chem. 2005;386:705-710.
17. Tharakan B, Hunter FA, Smythe WR, Childs EW. Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeability. Shock. 2008;30:571-577.
18. Berger AB, Sexton KB, Bogyo M. Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity. Cell Res. 2006;16:961-963.
19. Lamkanfi M, Declercq W, Kalai M, Saelens X, Vandenabeele P. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ. 2002;9:358-361.
20. Okuyama R, Nguyen BC, Talora C, Ogawa E, Tommasi di Vignano A, Lioumi M, et al. High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell. 2004;6:551-562.
21. Yan XX, Najbauer J, Woo CC, Dashtipour K, Ribak CE, Leon M. Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain. J Comp Neurol. 2001;433:4-22.
22. De Botton S, Sabri S, Daugas E, Zermati Y, Guidotti JE, Hermine O, et al. Platelet formation is the consequence of caspase activation within mega-karyocytes. Blood. 2002;100:1310-1317.
23. Zandy AJ, Lakhani S, Zheng T, Flavell RA, Bassnett S. Role of the executioner caspases during lens development. J Biol Chem. 2005;280: 30263-30272.
24. Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, Valensi F, et al. Caspase activation is required for terminal erythroid differentiation. J Exp Med. 2001;193:247-254.
25. Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, et al. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest. 2004;114:1704-1713.
26. Fernando P, Brunette S, Megeney LA. Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J. 2005;19: 1671-1673.
27. Woo M, Hakem R, Furlonger C, Hakem A, Duncan GS, Sasaki T, et al. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol. 2003;4:1016-1022.
28. Santambrogio L, Potolicchio I, Fessler SP, Wong SH, Raposo G, Strominger JL. Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells. Nat Immunol. 2005; 6:1020-1028.