Serotonin transporter genotype modulates cognitive reappraisal of negative emotions: A functional magnetic resonance imaging study

Social Cognitive and Affective Neuroscience

Volumn 8, Issue 3, 2013, Pages 247-258

  Firk, Christine ^a   Siep, Nicolette ^a   Rob Markus, C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

5 HTTLPR; Cognitive reappraisal; Emotion regulation; FMRI; Serotonin transporter gene

Indexed keywords

OXYGEN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BRAIN; BRAIN MAPPING; COGNITION; EMOTIONAL DISORDER; FEMALE; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETICS; GENOTYPE; HUMAN; IMAGE PROCESSING; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOSTIMULATION; PHYSIOLOGY; VASCULARIZATION;

AFFECTIVE SYMPTOMS; ANALYSIS OF VARIANCE; BRAIN; BRAIN MAPPING; COGNITION; FEMALE; GENETIC TESTING; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; PHOTIC STIMULATION; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 84875248269     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsr091     Document Type: Article

References (71)

1. Amunts, K., Kedo, O., Kindler, M., et al. (2005). Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anatomy, Embryology, 210(5-6), 343-52.
2. Beauregard, M., Paquette, V., Levesque, J. (2006). Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder. Neuroreport, 17(8), 843-6.
3. Bertolino, A., Arciero, G., Rubino, V., et al. (2005). Variation of human amygdala response during threatening stimuli as a function of 50HTTLPR genotype and personality style. Biological Psychiatry, 57(12), 1517-25.
4. Boynton, G.M., Engel, S.A., Glover, G.H., Heeger, D.J. (1996). Linear systems analysis of functional magnetic resonance imaging in human V1. Journal of Neuroscience, 16(13), 4207-21.
5. Bush, G., Luu, P., Posner, M.I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215-22.
6. Campbell-Sills, L., Simmons, A.N., Lovero, K.L., et al. (2011). Functioning of neural systems supporting emotion regulation in anxiety-prone individuals. Neuroimage, 54(1), 689-96.
7. Canli, T., Omura, K., Haas, B.W., et al. (2005). Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences United States of America, 102(34), 12224-9.
8. Caspi, A., Sugden, K., Moffitt, T.E., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-9.
9. Collier, D.A., Stober, G., Li, T., et al. (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry, 1(6), 453-60.
10. Cools, R., Roberts, A.C., Robbins, T.W. (2008). Serotoninergic regulation of emotional and behavioural control processes. Trends in Cognitive Sciences, 12(1), 31-40.
11. Cooney, R.E., Joormann, J., Eugene, F., Dennis, E.L., Gotlib, I.H. (2010). Neural correlates of rumination in depression. Cognitive, Affective & Behavioral Neuroscience, 10(4), 470-8.
12. Craig, A.D. (2009). How do you feel now? The anterior insula and human awareness. Nat Rev Neurosci, 10(1), 59-70.
13. Critchley, H.D., Tang, J., Glaser, D., Butterworth, B., Dolan, R.J. (2005). Anterior cingulate activity during error and autonomic response. Neuroimage, 27(4), 885-95.
14. Damasio, A.R., Grabowski, T.J., Bechara, A., et al. (2000). Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience, 3(10), 1049-56.
15. Dannlowski, U., Ohrmann, P., Bauer, J., et al. (2008). 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology, 33(2), 418-24.
16. Davidson, R.J., Abercrombie, H., Nitschke, J.B., Putnam, K. (1999). Regional brain function, emotion and disorders of emotion. Current Opinion in Neurobiology, 9(2), 228-34.
17. Davidson, R.J., Pizzagalli, D., Nitschke, J.B., Putnam, K. (2002). Depression: perspectives from affective neuroscience. Annu Rev Psychol, 53, 545-74.
18. Drabant, E.M., McRae, K., Manuck, S.B., Hariri, A.R., Gross, J.J. (2009). Individual differences in typical reappraisal use predict amygdala and prefrontal responses. Biological Psychiatry, 65(5), 367-73.
19. Eickhoff, S.B., Stephan, K.E., Mohlberg, H., et al. (2005). A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage, 25(4), 1325-35.
20. Glatz, K., Mossner, R., Heils, A., Lesch, K.P. (2003). Glucocorticoidregulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region. Journal of Neurochemistry, 86(5), 1072-8.
21. Gonda, X., Juhasz, G., Laszik, A., Rihmer, Z., Bagdy, G. (2005). Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene. Journal of Affective Disorders, 87(2-3), 291-7.
22. Gonda, X., Rihmer, Z., Zsombok, T., et al. (2006). The 5HTTLPR polymorphism of the serotonin transporter gene is associated with affective temperaments as measured by TEMPS-A. Journal of Affective Disorders, 91(2-3), 125-31.
23. Greenberg, B.D., Tolliver, T.J., Huang, S.J., et al. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics, 88(1), 83-7.
24. Gross, D., editor. (2007). Handbook of emotion regulation. New York: Guilford Press.
25. Gross, J.J., John, O.P. (2003). Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. Journal of Personality and Social Psychology, 85(2), 348-62.
26. Hariri, A.R., Drabant, E.M., Munoz, K.E., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62(2), 146-52.
27. Hariri, A.R., Mattay, V.S., Tessitore, A., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400-3.
28. Heinz, A., Braus, D.F., Smolka, M.N., et al. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8(1), 20-1.
29. Homberg, J.R., Lesch, K.P. (2011). Looking on the bright side of serotonin transporter gene variation. Biological Psychiatry, 69, 513-19.
30. Hooley, J.M., Gruber, S.A., Parker, H.A., et al. (2009). Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression. Psychiatry Research, 171(2), 106-19.
31. Hu, X., Oroszi, G., Chun, J., et al. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism Clinical and Experimental Research, 29(1), 8-16.
32. Jacobs, N., Kenis, G., Peeters, F., et al. (2006). Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Archives of General Psychiatry, 63(9), 989-96.
33. Johnstone, T., van Reekum, C.M., Urry, H.L., Kalin, N.H., Davidson, R.J. (2007). Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience, 27(33), 8877-84.
34. Joiner, T.E.Jr, Johnson, F., Soderstrom, K., Brown, J.S. (2003). Is there an association between serotonin transporter gene polymorphism and family history of depression? Journal of Affective Disorders, 77(3), 273-5.
35. Kalisch, R., Wiech, K., Herrmann, K., Dolan, R.J. (2006). Neural correlates of self-distraction from anxiety and a process model of cognitive emotion regulation. Journal of Cognotove Neuroscience, 18(8), 1266-76.
36. Karg, K., Burmeister, M., Shedden, K., Sen, S. (in press). The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation. Archives of General Psychiatry.
37. Kim, S.H., Hamann, S. (2007). Neural correlates of positive and negative emotion regulation. Journal of Cognitive Neuroscience, 19(5), 776-98.
38. Lamm, C., Batson, C.D., Decety, J. (2007). The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. Journal of Cognitive Neuroscience, 19(1), 42-58.
39. Lang, P.J., Bradley, M.M., Cuthbert, B.N. (2001). International Affective Picture System (IAPS): Techninal manual and affective ratings. NIMH Center for the Study of Emotion and Attention.
40. Lemogne, C., Gorwood, P., Boni, C., et al. (2011). Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity. Human Brain Mapping.
41. Lesch, K.P., Bengel, D., Heils, A., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274(5292), 1527-31.
42. Lotrich, F.E., Pollock, B.G. (2004). Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatric Genetics, 14(3), 121-9.
43. Maes, M., Meltzer, H.Y. (1995). The serotonin hypothesis of major depression. In: Bloom, F.E., Kupfer, D.J., editors. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, pp. 933-44.
44. Mansouri, F.A., Tanaka, K., Buckley, M.J. (2009). Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex. Nature Review Neuroscience, 10(2), 141-52.
45. Markus, C.R., De Raedt, R. (2011). Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge. Neuropsychopharmacology, 36(4), 819-26.
46. Markus, C.R., Firk, C. (2009). Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge. Neuropsychopharmacology, 34(13), 2667-74.
47. McCormick, L.M., Ziebell, S., Nopoulos, P., et al. (2006). Anterior cingulate cortex: an MRI-based parcellation method. Neuroimage, 32(3), 1167-75.
48. McRae, K., Hughes, B., Chopra, S., et al. (2010). The neural bases of distraction and reappraisal. Journal of Cognitive Neuroscience, 22(2), 248-62.
49. Mohanty, A., Engels, A.S., Herrington, J.D., et al. (2007). Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function. Psychophysiology, 44(3), 343-51.
50. Munafo, M.R., Brown, S.M., Hariri, A.R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry, 63(9), 852-7.
51. Neumeister, A., Hu, X.Z., Luckenbaugh, D.A., et al. (2006). Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Archives of General Psychiatry, 63(9), 978-86.
52. Ochsner, K.N., Bunge, S.A., Gabrieli, J.D. (2002). Rethinking feelings: an FMRI study of the cognitive regulation of emotion. Journal of Cognitive Neuroscience, 14(8), 1215-29.
53. Ochsner, K.N., Gross, J.J. (2005). The cognitive control of emotion. Trends in Cognitive Science, 9(5), 242-9.
54. Ochsner, K.N., Gross, J. (2008). Cognitive emotion regulation. Insights from social, cognitive and affective neuroscience. Current Directions in Psychological Science, 17(2), 153-8.
55. Ochsner, K.N., Ray, R.D., Cooper, J.C., et al. (2004). For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage, 23(2), 483-99.
56. Olsson, A., Ochsner, K.N. (2008). The role of social cognition in emotion. Trendsin Cognitive Science, 12(2), 65-71.
57. Paulus, M.P., Stein, M.B. (2006). An insular view of anxiety. Biological Psychiatry, 60(4), 383-7.
58. Pessoa, L., Adolphs, R. (2010). Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nature Review Neuroscience, 11(11), 773-83.
59. Pezawas, L., Meyer-Lindenberg, A., Drabant, E.M., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience, 8(6), 828-34.
60. Phan, K.L., Fitzgerald, D.A., Nathan, P.J., et al. (2005). Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study. Biological Psychiatry, 57(3), 210-9.
61. Phillips, M.L., Ladouceur, C.D., Drevets, W.C. (2008). A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Molecular Psychiatry, 13(9), 829 833-57.
62. Ray, R.D., Ochsner, K.N., Cooper, J.C., et al. (2005). Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cognitive Affective and Behavioral Neuroscience, 5(2), 156-68.
63. Schardt, D.M., Erk, S., Nusser, C., et al. (2010). Volition diminishes genetically mediated amygdala hyperreactivity. Neuroimage, 53(3), 943-51.
64. Shah, M.P., Wang, F., Kalmar, J.H., et al. (2009). Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder. Neuropsychopharmacology, 34(5), 1301-10.
65. Singer, T., Seymour, B., O'Doherty, J., et al. (2004). Empathy for pain involves the affective but not sensory components of pain. Science, 303(5661), 1157-62.
66. Sterzer, P., Stadler, C., Poustka, F., Kleinschmidt, A. (2007). A structural neural deficit in adolescents with conduct disorder and its association with lack of empathy. Neuroimage, 37(1), 335-42.
67. Straube, T., Miltner, W.H. (2011). Attention to aversive emotion and specific activation of the right insula and right somatosensory cortex. Neuroimage, 54(3), 2534-8.
68. Uher, R., McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Molecular Psychiatry, 13(2), 131-46.
69. Walderhaug, E., Magnusson, A., Neumeister, A., et al. (2007). Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biological Psychiatry, 62(6), 593-9.
70. Wilhelm, K., Mitchell, P.B., Niven, H., et al. (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry, 188, 210-5.
71. Zalsman, G., Huang, Y.Y., Oquendo, M.A., et al. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry, 163(9), 1588-93.