Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2031-2034

  Amblard, Franck ^a   Zhang, Hongwang ^a   Zhou, Longhu ^a   Shi, Junxing ^b   Bobeck, Drew R ^b   Nettles, James H ^a   Chavre, Satish ^a   McBrayer, Tamara R ^b   Tharnish, Philip ^b   Whitaker, Tony ^b   Coats, Steven J ^b   Schinazi, Raymond F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RFS Pharma LLC   (United States)

Author keywords

Antiviral agent; HCV; NS5A

Indexed keywords

CYTOCHROME P450; DACLATASVIR; NONSTRUCTURAL PROTEIN 5A;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C; HUMAN; HUMAN CELL; LIVER CELL CULTURE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; VERO CELL; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPACIVIRUS; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84875226968     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.023     Document Type: Article

References (24)

1. Hepatitis C-global prevalence (update). WHO wkly. Epidemio. rec 1999, 74, 425.
2. A.I. Kim, and S. Saab Am. J. Med. 118 2005 808
3. C. Sheridan Nat. Biotechnol. 29 2011 553
4. S.M. Lemon, J.A. McKeating, T. Pietschmann, D.N. Frick, J.S. Glenn, T.L. Tellinghuisen, J. Symons, and P.A. Furman Antivir. Res. 86 2010 79
5. M. Gao, R.E. Nettles, M. Belema, L.B. Snyder, V.N. Nguyen, R.A. Fridell, M.H. Serrano-Wu, D.R. Langley, J.H. Sun, D.R. O'Boyle II, J.A. Lemm, C. Wang, J.O. Knipe, C. Chien, R.J. Colonno, D.M. Grasela, N.A. Meanwell, and L.G. Hamann Nature 465 2010 96
6. T. Asselah J. Hepatol. 54 2011 1069
7. Sun, J.-H.; Gao, M.; O'Boyle, D. R. II.; Lemm, J. A.; Roberts, S. B.; Belema, M.; Meanwell, N. A. PCT Int. Appl. 2012, WO 2012009394 A2 20120119.
8. Lopez, O. D.; St. Laurent, D. R.; Goodrich, J.; Romine, J. Lee; Serrano-Wu, M.; Yang, F.-K.; Kakarla, R.; Yang, X.-J.; Qiu, Y.-P.; Snyder, L. B. U.S. Pat. Appl. Publ. 2011, US 20110294819 A1 20111201.
9. Belema, M.; Romine, J. L.; Nguyen, V. N.; Wang, G.; Lopez, O. D.; St. Laurent, D. R.; Chen, Q.; Bender, J. A.; Yang, Z.; Hewawasam, P.; Xu, N.-N.; Meanwell, N. A.; Easter, J. A.; Su, B.-N.; Smith, M. J. U.S. Pat. Appl. Publ. 2011, US 20110286961 A1 20111124.
10. Belema, M.; Hewawasam, P. U.S. Pat. Appl. Publ. 2011, US 20110237636 A1 20110929.
11. Bender, J. A.; Hewawasam, P.; Kadow, J. F.; Lopez, O. D.; Meanwell, N. A.; Nguyen, V. N.; Romine, J. L.; Snyder, L. B.; St. Laurent, D. R.; Wang, G.; Xu, N.-N.; Belema, M. PCT Int. Appl. 2010, WO 2010117635 A1 20101014.
12. Belema, M.; Nguyen, V. N.; Serrano-Wu, M.; St. Laurent, D. R.; Qiu, Y.-P., Ding, M.; Meanwell, N. A.; Snyder, L. B. U.S. Pat. Appl. Publ. 2010, US 20100080772 A1 20100401.
13. Bachand, C.; Belema, M.; Deon, D. H.; Good, A. C.; Goodrich, J.; Hamann, L. G.; James, C. A.; Langley, D. R.; Lavoie, R.; Lopez, O. D.; Martel, A.; Meanwell, N. A.; Nguyen, V. N.; Romine, J. L.; Ruediger, E. H.; Snyder, L. B.; St. Laurent, D. R.; Yang, F.-K., Wang, G. PCT Int. Appl. 2008, WO 2008144380 A1 20081127.
14. Milbank, J. B. J.; Tran, T. D.; Wakenhut, F. PCT Int. Appl. 2011, WO 2011154871 A1 20111215.
15. Vandyck, K.; Verschueren, W. G.; Raboisson, P. J.-M. B. PCT Int. Appl. 2012, WO 2012013643 A1 20120202.
16. Li, L.-P.; Zhong, M. PCT Int. Appl. 2011, WO 2011156543 A2 20111215.
17. Qiu, Y.-L.; Wang, C.; Ying, L.; Peng, X.-W.; Or, Y. S. PCT Int. Appl. 2010, WO 2010091413 A1 20100812.
18. Li, L.-P.; Zhong, M. PCT Int. Appl. 2011, WO 2011150243 A1 20111201.
19. Kim, S.; Gao, Q.; Yang, F.-K. U.S. Pat. Appl. Publ. 2010, US 20100158862 A1 20100624.
20. Bachand, C.; Belema, M.; Deon, D. H.; Good, A. C.; Goodrich, J.; James, C. A.; Lavoie, R.; Lopez, O. D.; Martel, A.; Meanwell, N. A.; Nguyen, V. N.; Romine, J. L.; Ruediger, E. H.; Snyder, L. B.; St. Laurent, D. R.; Yang, F.-K.; Langley, D. R.; Wang, G.; Hamann, L. G. PCT Int. Appl. 2009, WO 2009102318 A1 20090820.
21. Bachand, C.; Belema, M.; Deon, D. H.; Good, A. C.; Goodrich, J.; James, C. A.; Lavoie, R.; Lopez, O. D.; Martel, A.; Meanwell, N. A.; Nguyen, V. N.; Romine, J. L.; Ruediger, E. H.; Snyder, L. B.; St. Laurent, D. R.; Yang, F.-K., Langley, D. R.; Hamann, L. G. PCT Int. Appl. 2008, WO 2008021936 A2 20080221.
22. Belema, M.; Romine, J. L.; Nguyen, V. N.; Wang, G.; Lopez, O. D.; St. Laurent, D. R.; Chen, Q.; Bender, J. A.; Yang, Z.; Hewawasam, P.; Xu, N.-N.; Meanwell, N. A.; Easter, J. A.; Su, B.-N.; Smith, M. J. PCT Int. Appl. 2011, WO 2011075439 A1 20110623.
23. Corte, J. R.; Fang, T.; Decicco, C. P.; Pinto, D. J. P.; Rossi, K. A.; Hu, Z.-L.; Jeon, Y.; Quan, M. L.; Smallheer, J. M.; Wang, Y.-F.; Yang, W. PCT Int. Appl. 2011, WO 2011100401 A1 20110818.
24. H. Zhang, L. Zhou, F. Amblard, J. Shi, D.R. Bobeck, S. Tao, T.R. McBrayer, P.M. Tharnish, T. Whitaker, S.J. Coats, and R.F. Schinazi Bioorg. Med. Chem. Lett. 22 2012 4864