Genetically elevated levels of circulating triglycerides and brachial-ankle pulse wave velocity in a Chinese population

Journal of Human Hypertension

Volumn 27, Issue 4, 2013, Pages 265-270

  Yao, W M ^a   Zhang, H F ^a   Zhu, Z Y ^a   Zhou, Y L ^a   Liang, N X ^a   Xu, D J ^a   Zhou, F ^a   Sheng, Y H ^a   Yang, R ^a   Gong, L ^b   Yin, Z J ^c   Chen, F K ^d   Cao, K J ^a   Li, X L ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b Health Bureau of Gaoyou   (China)

^c Centre Clinics of Baoqiao   (China)

^d Centre Clinics of Songqiao   (China)

Author keywords

apolipoprotein A V gene; arterial stiffness; Mendelian randomization; triglycerides

Indexed keywords

APOLIPOPROTEIN A5; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; AGED; ANTIHYPERTENSIVE THERAPY; ARTERIAL STIFFNESS; ARTICLE; BODY MASS; BRACHIAL ANKLE PULSE WAVE VELOCITY; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO;

ADOLESCENT; ADULT; AGED; ANKLE BRACHIAL INDEX; APOLIPOPROTEINS A; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHI-SQUARE DISTRIBUTION; CHINA; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PULSE WAVE ANALYSIS; REGRESSION ANALYSIS; RISK ASSESSMENT; RISK FACTORS; TRIGLYCERIDES; UP-REGULATION; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 84875221234     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2012.23     Document Type: Article

References (32)

1. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308.
2. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S et al. Triglycerides and the risk of coronary heart disease: 10, 158 incident cases among 262, 525 participants in 29 Western prospective studies. Circulation 2007; 115: 450-458.
3. Miller M, Cannon CP, Murphy SA, Qin J, Ray KK, Braunwald E. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 2008; 51: 724-730.
4. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 2588-2605.
5. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010; 55: 1318-1327.
6. Wang KL, Cheng HM, Sung SH, Chuang SY, Li CH, Spurgeon HA et al. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study. Hypertension 2010; 55: 799-805.
7. Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010; 375: 1634-1639.
8. Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T et al. Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement-a survey of 12517 subjects. Atherosclerosis 2003; 166: 303-309.
9. Nakanishi N, Shiraishi T, Wada M. Brachial-ankle pulse wave velocity and metabolic syndrome in a Japanese population: the Minoh study. Hypertens Res 2005; 28: 125-131.
10. McEniery CM, Spratt M, Munnery M, Yarnell J, Lowe GD, Rumley A et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension 2010; 56: 36-43.
11. Ho CT, Lin CC, Hsu HS, Liu CS, Davidson LE, Li TC et al. Arterial Stiffness is Strongly Associated with Insulin Resistance in Chinese-A Population-Based Study (Taichung Community Health Study, TCHS). J Atheroscler Thromb 2010; 18: 122-130.
12. Anderson SG, Sanders TA, Cruickshank JK. Plasma fatty acid composition as a predictor of arterial stiffness and mortality. Hypertension 2009; 53: 839-845.
13. Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension 2009; 54: 1328-1336.
14. Wang F, Ye P, Luo L, Xiao W, Qi L, Bian S et al. Association of serum lipids with arterial stiffness in a population-based study in Beijing. Eur J Clin Invest 2011; 41: 929-936.
15. Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004; 33: 30-42.
16. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359-364.
17. Tsuchikura S, Shoji T, Kimoto E, Shinohara K, Hatsuda S, Koyama H et al. Brachial-ankle pulse wave velocity as an index of central arterial stiffness. J Atheroscler Thromb 2010; 17: 658-665.
18. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 2001; 294: 169-173.
19. Martin S, Nicaud V, Humphries SE, Talmud PJ. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta 2003; 1637: 217-225.
20. Lai CQ, Demissie S, Cupples LA, Zhu Y, Adiconis X, Parnell LD et al. Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study. J Lipid Res 2004; 45: 2096-2105.
21. Klos KL, Hamon S, Clark AG, Boerwinkle E, Liu K, Sing CF. APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study. J Lipid Res 2005; 46: 564-571.
22. Chandak GR, Ward KJ, Yajnik CS, Pandit AN, Bavdekar A, Joglekar CV et al. Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet 2006; 7: 76.
23. Hallman DM, Srinivasan SR, Chen W, Boerwinkle E, Berenson GS. Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study. Metabolism 2006; 55: 1574-1581.
24. Martinelli N, Trabetti E, Bassi A, Girelli D, Friso S, Pizzolo F et al. The-1131 T4C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study. Atherosclerosis 2007; 191: 409-417.
25. Jang Y, Paik JK, Hyun YJ, Chae JS, Kim JY, Choi JR et al. The apolipoprotein A5-1131 T4C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease. Clin Chim Acta 2009; 402: 83-87.
26. Baum L, Tomlinson B, Thomas GN. APOA5-1131T4C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet 2003; 63: 377-379.
27. Jiang CQ, Liu B, Cheung BM, Lam TH, Lin JM, Li Jin Y et al. A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese. Eur J Hum Genet 2010; 18: 1255-1260.
28. Zhang HF, Zhu ZY, Yao WM, Xu F, Gong L, Wu ZJ et al. Prevalence and risk factors of atrial fibrillation in a rural area of Jiangsu Province. J Clin Cardiol (Chinese) 2010; 26: 773-775.
29. Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008; 40: 189-197.
30. Olofsson SO. ApoA-V: the regulation of a regulator of plasma triglycerides. Arterioscler Thromb Vasc Biol 2005; 25: 1097-1099.
31. Zhao T, Zhao J. Association of the apolipoprotein A5 gene-1131 T4C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects. BMC Med Genet 2010; 11: 120.
32. The Reference Values for Arterial Stiffness' Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. Eur Heart J 2010; 31: 2338-2350.