Decreased hypothalamus volumes in generalized anxiety disorder but not in panic disorder

Journal of Affective Disorders

Volumn 146, Issue 3, 2013, Pages 390-394

  Terlevic, Robert ^a   Isola, Miriam ^a   Ragogna, Maria ^a   Meduri, Martina ^a   Canalaz, Francesca ^a   Perini, Laura ^a   Rambaldelli, Gianluca ^b   Travan, Luciana ^a   Crivellato, Enrico ^a   Tognin, Stefania ^b,c   Como, Giuseppe ^a   Zuiani, Chiara ^a   Bazzocchi, Massimo ^a   Balestrieri, Matteo ^a   Brambilla, Paolo ^a,d  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SCIENTIFIC INSTITUTE   (Italy)

Author keywords

Generalized anxiety disorder; Hypothalamus; Panic disorder; Structural magnetic resonance imaging

Indexed keywords

STRESS HORMONE;

ADULT; ANXIETY DISORDER; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PANIC; PRIORITY JOURNAL; SAMPLE SIZE; SCORING SYSTEM;

ADULT; ANXIETY DISORDERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; PANIC DISORDER; PITUITARY-ADRENAL SYSTEM; YOUNG ADULT;

EID: 84875220015     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.09.024     Document Type: Article

References (38)

1. J.L. Abelson, and G.C. Curtis Hypothalamic-pituitary-adrenal axis activity in panic disorder: 24-hour secretion of corticotropin and cortisol Archives of General Psychiatry 53 1996 323 331
2. J.L. Abelson, I. Liberzon, E.A. Young, and S. Khan Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjects Archives of General Psychiatry 62 2005 668
3. J.L. Abelson, S. Khan, I. Liberzon, and E.A. Young HPA axis activity in patients with panic disorder: review and synthesis of four studies Depression and Anxiety 24 2007 66 76
4. B. Bandelow, D. Wedekind, J. Pauls, A. Broocks, G. Hajak, and E. Rüther Salivary cortisol in panic attacks American Journal of Psychiatry 157 3 2000 454 456
5. P. Bollini, S. Pampallona, G. Tibaldi, B. Kupelnick, and C. Munizza Effectiveness of antidepressants. Meta-analysis of dose-effect relationships in randomised clinical trials British Journal of Psychiatry 174 1999 297 303
6. A. Bystritsky, D. Pontillo, M. Powers, F.W. Sabb, M.G. Craske, and S.Y. Bookheimer Functional MRI changes during panic anticipation and imagery exposure NeuroReport 12 2001 3953 3957
7. I. Chaudieu, I. Beluche, J. Norton, J.P. Boulenger, K. Ritchie, and M.L. Ancelin Abnormal reactions to environmental stress in elderly persons with anxiety disorders: evidence from a population study of diurnal cortisol changes Journal of Affective Disorders 106 2008 307 313
8. M. Colla, G. Kronenberg, M. Deuschle, K. Meichel, T. Hagen, M. Bohrer, and I. Heuser Hippocampal volume reduction and HPA-system activity in major depression Journal of Psychiatric Research 41 2007 553 560
9. J. Endicott, R.L. Spitzer, J.L. Fleiss, and J. Cohen The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance Archives of General Psychiatry 33 1976 766
10. A. Etkin, K.E. Prater, A.F. Schatzberg, V. Menon, and M.D. Greicius Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder Archives of General Psychiatry 66 2009 1361 1372
11. A. Etkin Functional neuroanatomy of anxiety: a neural circuit perspective M.B. Stein, T. Steckler, Behavioral Neurobiology of Anxiety and Its Treatment 2010 Springer 251 277
12. M.C. Ferrari, G.F. Busatto, P.K. McGuire, and J.A. Crippa Structural magnetic resonance imaging in anxiety disorders: an update of research findings Revista Brasileira de Psiquiatria 30 2008 251 264
13. C. Garcia-Leal, A.C. Parente, C.M. Del-Ben, F.S. Guimaraes, A.C. Moreira, L.L. Elias, and F.G. Graeff Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking Psychiatry Research 133 2005 239 252
14. M.G. Gelder, J.J.L. Ibor, and N.C. Andreasen New Oxford Textbook of Psychiatry 2000 Oxford University Press Oxford
15. S. Goldstein, U. Halbreich, G.M. Asnis, and J. Endicott The hypothalamic-pituitary-adrenal system in panic disorder American Journal of Psychiatry 144 1987 1320 1323
16. F.G. Graeff, and C.M. Del-Ben Neurobiology of panic disorder: from animal models to brain neuroimaging Neuroscience and Biobehavioral Reviews 32 2008 1326 1335
17. F.G. Graeff Anxiety, panic and the hypothalamic-pituitary-adrenal axis Revista Brasileira de Psiquiatria 29 Suppl. 1 2007 S3 S6
18. G.N.M. Gurguis, B.J. Vitton, and T.W. Uhde Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls Psychiatry Research 71 1997 27 39
19. M. Hamilton The assessment of anxiety states by rating British Journal of Medical Psychology 32 1959 50 55
20. F. Hayano, M. Nakamura, T. Asami, K. Uehara, T. Yoshida, T. Roppongi, T. Otsuka, T. Inoue, and H. Y. Smaller amygdala is associated with anxiety in patients with panic disorder Psychiatry and Clinical Neurosciences 63 2009 266 276
21. M.B. Hennessy, S.P. Mendoza, W.A. Mason, and G.P. Moberg Endocrine sensitivity to novelty in squirrel monkeys and titi monkeys: species differences in characteristic modes of responding to the environment Physiology & Behavior 57 1995 331 338
22. F. Holsboer, U. von Bardeleben, R. Buller, I. Heuser, and A. Steiger Stimulation response to corticotropin-releasing hormone (CRH) in patients with depression, alcoholism and panic disorder Hormone and Metabolic Research Supplement Series 16 1987 80 88
23. S. Kartalci, M. Dogan, S. Unal, A.C. Ozcan, S. Ozdemir, and M. Atmaca Pituitary volume in patients with panic disorder Progress in Neuro-Psychopharmacology and Biological Psychiatry 35 2011 203 207
24. A. Klomp, P.C. Koolschijn, H.E. Hulshoff Pol, R.S. Kahn, and N.E. Van Haren Hypothalamus and pituitary volume in schizophrenia: a structural MRI study International Journal of Neuropsychopharmacology 2011 1 8
25. E.J. Lenze, R.C. Mantella, P. Shi, A.M. Goate, P. Nowotny, M.A. Butters, C. Andreescu, P.A. Thompson, and B.L. Rollman Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram American Journal of Geriatric Psychiatry 19 2011 482 490
26. S. Levine Influence of psychological variables on the activity of the hypothalamic-pituitary-adrenal axis European Journal of Pharmacology 405 2000 149 160
27. R.C. Mantella, M.A. Butters, J.A. Amico, S. Mazumdar, B.L. Rollman, A.E. Begley, C.F. Reynolds, and E.J. Lenze Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder Psychoneuroendocrinology 33 2008 773 781
28. J.W. Mason A historical view of the stress field Journal of Human Stress 1 1975 22 36
29. R. Nieuwenhuys, J. Voogd, and C. van Huijzen The Human Central Nervous System 2008 Springer Verlag
30. R.C. Oldfield The assessment and analysis of handedness: the Edinburgh inventory Neuropsychologia. 9 1971 97 113
31. H.E.H. Pol, P.T. Cohen-Kettenis, N.E.M. Van Haren, J.S. Peper, R.G.H. Brans, W. Cahn, H.G. Schnack, L.J.G. Gooren, and R.S. Kahn Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure European Journal of Endocrinology 155 2006 S107
32. R.M. Sapolsky Stress, glucocorticoids, and damage to the nervous system: the current state of confusion Stress 1 1996 1 19
33. A. Schienle, F. Ebner, and A. Schafer Localized gray matter volume abnormalities in generalized anxiety disorder European Archives of Psychiatry and Clinical Neuroscience 261 2011 303 307
34. H. Vedder Physiology of the hypothalamic-pituitary-adrenocortical axis A. Del Rey, G.P. Chrousos, H.O. Besedovsky, The Hypothalamus-Pituitary-Adrenal Axis 2007 Elsevier 17 31
35. J. Ventura, K.H. Nuechterlein, K.L. Subotnik, D. Gutkind, and E.A. Gilbert Symptom dimensions in recent-onset schizophrenia and mania: a principal components analysis of the 24-item Brief Psychiatric Rating Scale Psychiatry Research 97 2000 129 135
36. P. Videbech, and B. Ravnkilde Hippocampal volume and depression: a meta-analysis of MRI studies American Journal of Psychiatry 161 2004 1957 1966
37. S.A. Vreeburg, F.G. Zitman, J. van Pelt, R.H. Derijk, J.C. Verhagen, R. van Dyck, W.J. Hoogendijk, J.H. Smit, and B.W. Penninx Salivary cortisol levels in persons with and without different anxiety disorders Psychosomatic Medicine 72 2010 340 347
38. J.M. Weiss Effects of coping responses on stress Journal of Comparative and Physiological Psychology 65 1968 251 260