Accumulation of tissue macrophages and depletion of resident macrophages in the diabetic thymus in response to hyperglycemia-induced thymocyte apoptosis

Journal of Diabetes and its Complications

Volumn 27, Issue 2, 2013, Pages 114-122

  Barbu Tudoran, Lucian ^a   Gavriliuc, Oana I ^b   Paunescu, Virgil ^b   Mic, Felix A ^c  

^a BABE BOLYAI UNIVERSITY   (Romania)

^b VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c Regional Center for Immunology of Transplantation   (Romania)

Author keywords

Diabetes; Macrophage accumulation; Phagocytosis; Rat; Thymic stroma; Thymocytes

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; GELATINASE A; GELATINASE B; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; BODY WEIGHT; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA DEGRADATION; DYNAMICS; ELECTRON MICROSCOPY; FEMALE; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INVOLUTION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; THYMOCYTE; THYMUS;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; DIABETES COMPLICATIONS; ECTODYSPLASINS; FEMALE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; LYMPHATIC DISEASES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; STROMAL CELLS; THYMOCYTES; THYMUS GLAND; UP-REGULATION; VACUOLES;

EID: 84875218935     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2012.10.007     Document Type: Article

References (31)

1. M.P. Armengol, L. Sabater, M. Fernández, M. Ruíz, N. Alonso, and M.J. Otero Influx of recent thymic emigrants into autoimmune thyroid disease glands in humans Clinical and Experimental Immunology 153 2008 338 350
2. R. Balasubramanian, J.F. Hofert, and M.L. Heidrick Suppressed proliferation of lymphatic tissue in diabetic and adrenalectomized-diabetic rats Immunopharmacology 10 1985 83 88
3. B.B. Barone, H.C. Yeh, C.F. Snyder, K.S. Peairs, K.B. Stein, and R.L. Derr Long- term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis Journal of the American Medical Association 2008 300 2008 2754 2764
4. S.P. Berzins, E.S. Venanzi, C. Benoist, and D. Mathis T-cell compartments of prediabetic NOD mice Diabetes 52 2003 327 334
5. R. Ceredig, and T. Rolink A positive look at double-negative thymocytes Nature Reviews Immunology 2 2002 888 897
6. K. Chatamra, P.M. Daniel, M.D. Kendall, and D.K. Lam Atrophy of the thymus in rats rendered diabetic by streptozotocin Hormone and Metabolic Research 17 1985 630 632
7. E. Esashi, T. Sekiguchi, H. Ito, S. Koyasu, and A. Miyajima Cutting edge: a possible role for CD4 + thymic macrophages as professional scavengers of apoptotic thymocytes The Journal of Immunology 171 2003 2773 2777
8. A.T. Gruia, L. Barbu-Tudoran, A.A. Mic, V.L. Ordodi, V. Paunescu, and F.A. Mic Arachidonic acid accumulates in the stromal macrophages during thymus involution in diabetes Histochemistry and Cell Biology 136 2011 79 92
9. M.A. Hayat Principles and techniques of electron microscopy: biological applications 2000 Cambridge University Press London
10. M.L. Hermiston, Z. Xu, and A. Weiss CD45: a critical regulator of signaling thresholds in immune cells Annual Review of Immunology 21 2003 107 137
11. J. Hofer, S. Hofer, M. Zlamy, V. Jeller, C. Koppelstaetter, and A. Brandstätter Elevated proportions of recent thymic emigrants in children and adolescents with type 1 diabetes Rejuvenation Research 12 2009 311 320
12. H.H. Huang, T.Y. Tsao, and H.S. Lee Effects of (-)-epigallocatechin-3- gallate on cyclooxygenase 2 and matrix metalloproteinase 3, 9, 13 expression induced by IL-1ß in rat meniscal fibrochondrocytes Journal of Food and Drug Analysis 17 2009 459 466
13. T. Hünig, N. Torres-Nagel, B. Mehling, H.J. Park, and T. Herrmann Thymic development and repertoire selection: the rat perspective Immunological Reviews 184 2001 7 19
14. J. Kampinga, and R. Aspinall Turnover of ED2-expressing macrophages in the thymus cortex of rats Thymus 13 1989 205 212
15. A. Junod, A.E. Lambert, L. Orci, R. Pictet, A.E. Gonet, and A.E. Renold Studies of the diabetogenic action of streptozotocin Proceedings of the Society for Experimental Biology and Medicine 126 1967 201 205
16. A.A. Like, and A.A. Rossini Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus Science 193 1976 415 417
17. A.A. Mic, F.A. Mic, C.A. Tatu, M. Ionac, V.L. Ordodi, and V. Paunescu Indomethacin inhibits thymic involution in mice with streptozotocin-induced diabetes Comparative Medicine 57 2007 476 481
18. L.M.A.J. Muller, K.J. Gorter, E. Hak, W.L. Goudzwaard, F.G. Schellevis, and A.I.M. Hoepelman Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus Clinical Infectious Diseases 41 2005 281 288
19. C. Odaka, and T. Mizuochi Macrophages are involved in DNA degradation of apoptotic cells in murine thymus after administration of hydrocortisone Cell Death and Differentiation 9 2002 104 112
20. S.G. Paik, N. Fleischer, and S.I. Shin Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes Proceedings of the National Academy of Sciences of the United States of America 77 1980 6129 6133
21. H.T. Petrie, and P.W. Kincade Many roads, one destination for T cell progenitors The Journal of Experimental Medicine 202 2005 11 13
22. G.M. Risinger Jr., T.S. Hunt, D.L. Updike, E.C. Bullen, and E.W. Howard Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors The Journal of Biological Chemistry 281 2006 25915 25925
23. A. Roldán, M.C. Filgueira, and M.B. Castillo Effect of streptozotocin-diabetes on thymus of normal and adrenalectomized rats Acta Physiol Latin Am 30 1980 205 210
24. A.G. Rolink, S. Massa, G. Balciunaite, and R. Ceredig Early lymphocyte development in bone marrow and thymus Swiss Medical Weekly 28 2006 679 683
25. A.A. Rossini, A.A. Like, W.L. Chick, M.C. Appel, and G.F. Cahill Studies of streptozotocin-induced insulitis and diabetes Proceedings of the National Academy of Sciences of the United States of America 74 1977 2485 2489
26. P. Schein, R. Kahn, P. Gorden, S. Wells, and V.T. Devita Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature Archives of Internal Medicine 132 1973 555 561
27. H.J. Schuurman, C.F. Kuper, and M.D. Kendall Thymic microenvironment at the light microscopic level Microscopy Research and Technique 38 1997 216 226
28. T. Tabata, Y. Okuno, S. Fujii, S. Kimura, and Y. Kinoshita Maturational impairment of thymic lymphocytes in streptozotocin-induced diabetes in rats Cellular Immunology 89 1984 250 258
29. D.R. Tulsiani, and O. Touster Thymus involution and inhibition of spleen growth accompanies streptozotocin-induced diabetes in rats; possible relationship of these changes to the elevated hydrolase levels in diabetic plasma Archives of Biochemistry and Biophysics 208 1981 59 68
30. S.R. Wellhausen Definition of streptozocin toxicity for primary lymphoidal tissues Diabetes 35 1986 1404 1411
31. H. Yang, Y.H. Youm, B. Vandanmagsar, J. Rood, K.G. Kumar, and A.A. Butler Obesity accelerates thymic aging Blood 29 2009 3803 3812