Modeling the effects of caffeine on the sleep/ wake cycle

Biomedical Sciences Instrumentation

Volumn 48, Issue , 2012, Pages

  Daniello, Allison ^a   Fievisohn, Elizabeth ^a   Gregory, T Stan ^a  

^a Virginia Tech Wake Forest School of Biomedical Engineering and Sciences   (United States)

Author keywords

Adenosine; Caffeine; Circadian; Flip flop; Homeostatic drive; Sleep cycle; Sleep homeostat

Indexed keywords

CAFFEINE; FLIP FLOP CIRCUITS; WAKES;

ADENOSINE; CIRCADIAN; FLIP-FLOP; HOMEOSTATIC DRIVES; SLEEP CYCLE; SLEEP HOMEOSTAT;

SLEEP RESEARCH;

CAFFEINE;

ARTICLE; CIRCADIAN RHYTHM; HOMEOSTASIS; SLEEP PATTERN; SLEEP WAKING CYCLE; WAKEFULNESS;

EID: 84875216560     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. H.P. Landolt. "Sleep Homeostasis: A Role for Adenosine in Humans?" Biochem Pharmacol, vol. 75, no. 11, pp. 2070-79, June, 2008.
2. R. Basheer, R.E. Strecker, M.M. Thakkar, R.W. McCarley. "Adenosine and Sleep-Wake Regulation, " Prog Neurobiol, vol. 73, no. 6, pp. 379-96, Aug, 2004.
3. Z.W. Liu, X.B. Gao. "Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect, " J Neurophysiol, vol. 97, no. 1, pp. 837-48, Jan., 2007.
4. C. Alford, J. Bhatti, T. Leigh, A. Jamieson, I. Hindmarch. "Caffeine-Induced Sleep Disruption: Effects on Waking the Following Day and Its Reversal with an Hypnotic, " Hum Psychopharmacol, vol. 11, no. 3, pp. 185-98, May, 1996.
5. C. Drapeau, I. Hamel-Hebert, R. Robillard, B. Selmaoui, D. Filipini, J. Carrier. "Challenging Sleep in Aging: The Effects of 200 Mg of Caffeine During the Evening in Young and Middle-Aged Moderate Caffeine Consumers, " J Sleep Research, vol. 15, no. 2, pp. 133-41, June, 2006.
6. H.P. Landolt, J.V. Retey, K. Tonz, J.M. Gottselig, R. Khatami, I. Buckelmuller, P. Achermann. "Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans, " Neuropsychopharmacology, vol. 29, pp. 1933-39, 2004.
7. J.A. Murphy, S. Deurveilher, K. Semba. "Stimulant Doses of Caffeine Induce C-Fos Activation in Orexin/Hypocretin-Containing Neurons in Rat, " Neuroscience, vol. 121, no. 2, pp. 269-75, Oct., 2003.
8. M.J. Rempe, J. Best, D. Terman. "A Mathematical Model of the Sleep/Wake Cycle, " J Math Biol, vol. 60, no. 5, pp. 615-44, May, 2010.
9. C.B. Saper, T.E. Scammell, J. Lu. "Hypothalamic regulation of sleep and circadian rhythms, " Nature, vol. 437, no. 7063, pp. 1257-1263, Oct., 2005.
10. M. Puckeridge, B.D. Fulcher, A.J.K. Phillips, P.A. Robinson. "Incorporation of Caffeine into a Quantitative Model of Fatigue and Sleep, " J Theor Biol, vol. 273, no. 1, pp., 44-54, Mar., 2011.
11. A.J.K. Phillips, P.A. Robinson. "A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system, " J. Biol Rhythms, vol. 22, no. 2, pp. 167-179, Apr., 2007.
12. I. Karacan, J.I. Thornby, A.M. Anch, G.H.B. Junior, R.L. Williams, P.J. Salis. "Dose-related sleep disturbances induced by coffee and caffeine, " Clin. Pharmacol. Ther, vol. 20, no. 6, pp. 682-689, Dec. 1976.
13. V. Brezinova. "Effect of caffeine on sleep: EEG study in late middle age people, " Br. J. Clin. Pharmacol, vol. 1 no. 3, pp. 203-208, June, 1974.
14. T. Okuma, H. Matsuoka, Y. Matsue, K. Toyomura. "Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam" Psychopharmacol, vol. 76, no. 3, pp. 201-208, 1982.
15. J. Carrier, M. Fernandez-Bolanos, R. Robillard, M. Dumont, J. Paquet, B. Selmaoui, D. Filipini. "Effects of caffeine are more marked on daytime recovery sleep than nocturnal sleep, " Neuropsychopharamacology, vol. 32, pp. 964-972, 2007.