Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic - Targeting Mycobacterium tuberculosis ribonucleotide reductase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1992-2000

  Nurbo, Johanna ^a   Ericsson, Daniel J ^a   Rosenström, Ulrika ^a   Muthas, Daniel ^a   Jansson, Anna M ^a   Lindeberg, Gunnar ^a   Unge, Torsten ^a   Karlén, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Mycobacterium tuberculosis; Peptide inhibitor; Pseudopeptide; Ribonucleotide reductase

Indexed keywords

(9H FLUOREN 9 YL)METHYL 2 [(1H INDOL 3 YL)METHYL] 4 (2 HYDROXYETHYL) 3 OXO 2,3,4,5 TETRAHYDRO 1H BENZOLE[E][1,4]DIAZEPIN 9 YLCARBAMATE; 2 (TERT BUTYLDIMETHYLSILYLOXY) N (2 CHLORO 3 NITROBENZYL)ETHANAMINE; 2 [(1H INDOL 3 YL)METHYL] 4 [2 (TERT BUTYLDIMETHYLSILYLOXY)ETHYL] 9 NITRO 4,5 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 (2H) ONE; 2 [2 [(1H INDOL 3 YL)METHYL] 9 [[(9H FLUOREN 9 YL)METHOXY]CARBONYLAMINO] 3 OXO 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 4(5H) YL]ACETIC ACID; 2 [2 [[1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL]METHYL] 9 NITRO 3 OXO 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 4(5H) YL]ACETIC ACID; 2 [9 [[(9H FLUOREN 9 YL)METHOXY]CARBONYLAMINO] 2 [[1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL]METHYL] 3 OXO 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 4(5H) YL]ACETIC ACID; 2 AMINO N [2 (TERT BUTYLDIMETHYLSILYLOXY)ETHYL] N (2 CHLORO 3 NITROBENZYL) 3 (1H INDOL 3 YL)ETHANAMINE; 2 CHLORO 3 NITROBENZALDEHYDE; BENZODIAZEPINE DERIVATIVE; PSEUDOPEPTIDE; RIBONUCLEOTIDE REDUCTASE; TERT BUTYL 3 [[4 (2 HYDROXYETHYL) 9 NITRO 3 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[E][1,4]DIAZEPIN 2 YL]METHYL] 1H INDOLE 1 CARBOXYLATE; TERT BUTYL 3 [[4 [2 (TERT BUTYLDIMETHYLSILYLOXY)ETHYL] 9 NITRO 3 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[E][1,4]DIAZEPIN 2 YL]METHYL] 1H INDOLE 1 CARBOXYLATE; TERT BUTYL 3 [[9 [[(9H FLUOREN 9 YL)METHOXY]CARBONYLAMINO] 4 [2 (TERT BUTYLDIMETHYLSILYLOXY)ETHYL] 3 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[E][1,4]DIAZEPIN 2 YL]METHYL] 1H INDOLE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; FLUORESCENCE POLARIZATION; HYDROPHOBICITY; IC 50; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PEPTIDE SYNTHESIS; SALMONELLA TYPHIMURIUM; SOLVATION;

AMINO ACID SEQUENCE; BENZODIAZEPINES; HUMANS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOMIMETICS; RIBONUCLEOTIDE REDUCTASES; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS; SALMONELLA TYPHIMURIUM;

EID: 84875216302     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.020     Document Type: Article

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