Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: A retrospective clinical pathologic analysis of 138 cases

American Journal of Surgical Pathology

Volumn 37, Issue 4, 2013, Pages 606-612

  Volante, Marco ^a   Daniele, Lorenzo ^a   Asioli, Sofia ^a   Cassoni, Paola ^a   Comino, Alberto ^b   Coverlizza, Sergio ^c   De Giuli, Paolo ^d   Fava, Cristina ^e,f   Manini, Claudia ^a,d   Berruti, Alfredo ^a   Papotti, Mauro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Giovanni Bosco Hospital   (Italy)

^c MAURIZIANO HOSPITAL   (Italy)

^d S CROCE E CARLE HOSPITAL   (Italy)

^e Santa Croce Hospital   (Italy)

^f Alba Bra Hospital   (Italy)

Author keywords

appendix; carcinoid; neuroendocrine tumor; prognosis; staging

Indexed keywords

ADOLESCENT; ADULT; AGED; APPENDIX TUMOR; ARTICLE; CANCER GRADING; CANCER STAGING; CARCINOMA; CHILD; CLASSIFICATION; FEMALE; HUMAN; ITALY; MALE; MIDDLE AGED; MITOSIS; MORTALITY; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SURVIVAL RATE; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APPENDICEAL NEOPLASMS; CARCINOMA, NEUROENDOCRINE; CHILD; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; MITOSIS; NEOPLASM GRADING; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; WORLD HEALTH ORGANIZATION; YOUNG ADULT;

EID: 84875213926     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318275d1d7     Document Type: Article

References (25)

1. Gustafsson BI, Siddique L, Chan A, et al. Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy. Int J Oncol. 2008;33:1121-1131.
2. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063-3072.
3. Niederle MB, Hackl M, Kaserer K, et al. Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer. 2010;17:909-918.
4. Marudanayagam R, Williams GT, Rees BI. Review of the pathological results of 2660 appendicectomy specimens. J Gastroenterol. 2006;41:745-749.
5. Tchana-Sato V, Detry O, Polus M, et al. Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies. World J Gastroenterol. 2006;12:6699-6701.
6. In't Hof KH, van der Wal HC, Kazemier G, et al. Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg. 2008;12:1436-1438.
7. Shapiro R, Eldar S, Sadot E, et al. The significance of occult carcinoids in the era of laparoscopic appendectomies. Surg Endosc. 2010;24:2197-2199.
8. Shapiro R, Eldar S, Sadot E, et al. Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg. 2011;201:805-808.
9. Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol. 2011;17:1961-1970.
10. Maggard MA, O'Connell JB, Ko CY. Updated population-based review of carcinoid tumors. Ann Surg. 2004;240:117-122.
11. Boudreaux JP, Klimstra DS, Hassan MM, et al. The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum. Pancreas. 2010;39: 753-766.
12. Mullen JT, Savarese DM. Carcinoid tumors of the appendix: a population-based study. J Surg Oncol. 2011;104:41-44.
13. Washington MK, Tang LH, Berlin J, et al. Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix. Arch Pathol Lab Med. 2010;134:171-175.
14. Deschamps L, Couvelard A. Endocrine tumors of the appendix: a pathologic review. Arch Pathol Lab Med. 2010;134:871-875.
15. Bosman FT, Carneiro F, Hruban RH, et al. World Health Organization Classification of Tumours. Pathology and Genetics. Tumors of the Digestive System. Lyon: IARC Press; 2010: 126-128.
16. Rindi G, Kloppel G, Couvelard A, et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2007;451:757-762.
17. Edge SB, Byrd DR, Compton CC, et al. AJCC Cancer Staging Handbook. 7th ed. New York: Springer; 2010:161-171.
18. Parkes SE, Muir KR, al Sheyyab M, et al. Carcinoid tumours of the appendix in children 1957-1986: incidence, treatment and outcome. Br J Surg. 1993;80:502-504.
19. Prommegger R, Obrist P, Ensinger C, et al. Retrospective evaluation of carcinoid tumors of the appendix in children. World J Surg. 2002;26:1489-1492.
20. Khan RA, Ghani I, Chana RS. Routine histopathological examination of appendectomy specimens in children: is there any rationale? Pediatr Surg Int. 2011;27:1313-1315.
21. Pape UF, Perren A, Niederle B, et al. ENETS Consensus Guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas. Neuroendocrinology. 2012;95:135-156.
22. Solcia E, Kloppel G, Sobin L. World Health Organization International Histological Classification of Tumors. Histological Typing of Endocrine Tumors. Berlin: Springer; 2000:67-68.
23. Jann H, Roll S, Couvelard A, et al. Neuroendocrine tumors of midgut and hindgut origin: tumor-node-metastasis classification determines clinical outcome. Cancer. 2011;117:3332-3341.
24. Strosberg J, Nasir A, Coppola D, et al. Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors. Hum Pathol. 2009;40:1262-1268.
25. Alexandraki KI, Griniatsos J, Bramis KI, et al. Clinical value of right hemicolectomy for appendiceal carcinoids using pathologic criteria. J Endocrinol Invest. 2011;34:255-259.