Results of a phase 2 study examining the effects of omitting elective neck irradiation to nodal levels IV and Vb in patients with N 0-1 nasopharyngeal carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 85, Issue 4, 2013, Pages 929-934

  Chen, Jian Zhou ^a   Le, Quynh Thu ^d   Han, Fei ^b,c   Lu, Li Xia ^b,c   Huang, Shao Min ^b,c   Lin, Cheng Guang ^b,c   Deng, Xiao Wu ^b,c   Cui, Nian Ji ^b,c   Zhao, Chong ^b,c  

^a CANCER HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

DISTANT METASTASIS; FAILURE-FREE SURVIVAL; INTENSITY-MODULATED RADIATION THERAPY; METHODS AND MATERIALS; NASOPHARYNGEAL CARCINOMA; OVERALL SURVIVAL RATES; PROSPECTIVE STUDY; REGIONAL CONTROLS;

DERMATITIS; IRRADIATION; PATIENT MONITORING; PHYSICAL THERAPY; TOXICITY;

PATIENT TREATMENT;

CISPLATIN; FLUOROURACIL;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; CONTINUOUS INFUSION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; METASTASIS; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; SKIN ATROPHY; SKIN FIBROSIS; TREATMENT OUTCOME; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; BRACHYTHERAPY; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC IRRADIATION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NECK; NEOPLASM STAGING; ORGAN SPARING TREATMENTS; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; SURVIVAL RATE; XEROSTOMIA; YOUNG ADULT;

EID: 84875195171     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.07.2356     Document Type: Article

References (20)

1. S.H. Ng, J.T. Chang, and S.C. Chan Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET Eur J Nucl Med Mol Imaging 31 2004 1073 1080
2. L. Tang, Y. Mao, and L. Liu The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging Cancer 115 2009 680 688
3. K.S. Chao, F.J. Wippold, and G. Ozyigit Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT Int J Radiat Oncol Biol Phys 53 2002 1174 1184
4. V. Gregoire, P. Levendag, and K.K. Ang CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines Radiother Oncol 69 2003 227 236
5. Xian Chaogui, and Zhang Enpei Radiation treatment of neck for nasopharyngeal carcinoma with negative cervical lymph nodes Chinese J Cancer 15 1996 137 138
6. nd ed 1993 Beijin Medical University & Xiehe Medical University Press 453
7. W.W. Xiao, S.M. Huang, and F. Han Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study Cancer 117 2011 1874 1883
8. P.M. Som, H.D. Curtin, and A.A. Mancuso An imaging-based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications Arch Otolaryngol Head Neck Surg 125 1999 388 396
9. L.A. Dawson, Y. Anzai, and L. Marsh Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer Int J Radiat Oncol Biol Phys 46 2000 1117 1126
10. Cancer Therapy Evaluation Program. Common terminology criteria for adverse events, Version 3.0, DCTD, NCI, NIH, DHHS. Available at: http://ctep.cancer.gov/protocolDevelopment/electronic- applications / docs/ctcae-glossary.pdf; 2003. Accessed July 8, 2010.
11. J.S. Sham, D. Choy, and W.I. Wei Nasopharyngeal carcinoma: orderly neck node spread Int J Radiat Oncol Biol Phys 19 1990 929 933
12. A.W. Lee, Y.F. Poon, and W. Foo Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure Int J Radiat Oncol Biol Phys 23 1992 261 270
13. D.X. Qin, Y.H. Hu, and J.H. Yan Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation Cancer 61 1988 1117 1124
14. Xian Chaogui, Lin Huangxin, and Zhen Lie Analysis of the cervical CT scan for 79 patients with nasophryngeal carcinoma Chinese J Cancer 17 1998 307 308
15. X. Wang, L. Li, and C. Hu Patterns of level II node metastasis in nasopharyngeal carcinoma Radiother Oncol 89 2008 28 32
16. Y. Sun, J. Ma, and T.X. Lu Regulation for distribution of metastatic cervical lymph nodes of 512 cases of nasopharyngeal carcinoma Ai Zheng 23 2004 1523 1527
17. F.C. Ho, I.W. Tham, and A. Earnest Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence BMC Cancer 12 2012 March 21 98 [Epub ahead of print]
18. C.Z. Chen, D.R. Li, and Z.J. Chen Long-term efficacy of prophylactic upper neck irradiation for stage N0 nasopharyngeal carcinoma Ai Zheng 27 2008 295 298
19. Y. Gao, G. Zhu, and J. Lu Is elective irradiation to the lower neck necessary for N0 nasopharyngeal carcinoma? Int J Radiat Oncol Biol Phys 77 2010 1397 1402
20. M. Little, M. Schipper, and F.Y. Feng Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands Int J Radiat Oncol Biol Phys 83 3 2012 1007 1014