Does hormone replacement therapy cause breast cancer? Commentary on Shapiro et al. papers, Parts 1-5

Journal of Family Planning and Reproductive Health Care

Volumn 39, Issue 2, 2013, Pages 72-74

  Panay, Nick ^a,b,c  

^a British Menopause Society   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CANCER RISK; CLINICAL TRIAL (TOPIC); FEMALE; HORMONE SUBSTITUTION; HUMAN; MEDICAL SOCIETY; MENOPAUSE; NOTE; ADVERSE EFFECTS; BREAST TUMOR; CHEMICALLY INDUCED; DRUG EFFECTS; MIDDLE AGED;

BREAST NEOPLASMS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MENOPAUSE; MIDDLE AGED;

EID: 84875195167     PISSN: 14711893     EISSN: None     Source Type: Journal    
DOI: 10.1136/jfprhc-2013-100578     Document Type: Note

References (19)

1. Collaborative Group on Hormonal factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. Lancet 1997;350:1047-1059.
2. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's health initiative randomised controlled trial. JAMA 2002;288:321-333.
3. Million Women Study Collaborators. Breast cancer and HRT in the Million Women Study. Lancet 2003;362:419-427.
4. Cumming GP, Currie HD, Panay N, et al. Stopping hormone replacement therapy: were women ill advised? Menopause Int 2011;17:82-87.
5. Shapiro S, Farmer RD, Mueck AO, et al. Does hormone replacement therapy cause breast cancer? An application of causal principles to three studies. Part 1. The Collaborative Reanalysis. J Fam Plann Reprod Health Care 2011;37:103-109.
6. Shapiro S, Farmer RD, Mueck AO, et al. Does hormone replacement therapy cause breast cancer? An application of causal principles to three studies: Part 2. The Women's Health Initiative: estrogen plus progestogen. J Fam Plann Reprod Health Care 2011;37:165-172.
7. Shapiro S, Farmer RD, Mueck AO, et al. Does hormone replacement therapy cause breast cancer? An application of causal principles to three studies: Part 3. The Women's Health Initiative: unopposed estrogen. J Fam Plann Reprod Health Care. 2011;37:225-230.
8. Shapiro S, Farmer RD, Stevenson JC, et al. Does hormone replacement therapy cause breast cancer? An application of causal principles to three studies: Part 4: The Million Women Study. J Fam Plann Reprod Health Care 2012;38:102-109.
9. Shapiro S, Farmer RD, Stevenson JC, et al. Does hormone replacement therapy (HRT) cause breast cancer? An application of causal principles to three studies: Part 5. Trends in breast cancer incidence in relation to the use of HRT. J Fam Plann Reprod Health Care 2013;39:80-88.
10. Fenton A, Panay N. The Women's Health Initiative - a decade of progress. Climacteric 2012;15:205.
11. Utian WH. A decade post WHI, menopausal hormone therapy comes full circle - need for independent commission. Climacteric 2012;15:320-325.
12. Ravdin PM, Cronin KA, Howlader N, et al. The decrease in incidence of breast cancer in the United States. N Engl J Med 2007;356:1670-1674.
13. Robbins AS, Clarke CA. Regional changes in hormone therapy use and breast cancer incidence in California from 2001 to 2004. J Clin Oncol 2007;26:3437-3439.
14. Fournier A, Fabre A, Mesrine S, et al. Use of different postmenopausal hormone therapies and risk of histology- and hormone receptor-defined invasive breast cancer. J Clin Oncol 2008;26:1260-1268.
15. Harman SM, Brinton EA, Cedars M, et al. KEEPS: the Kronos Early Estrogen Prevention Study. Climacteric 2005;8:3-12.
16. Kronos Longevity Research Institute. Hormone therapy has many favorable effects in newly menopausal women: initial findings of the Kronos Early Estrogen Prevention Study (KEEPS). Press release dated 3 October 2012. http://www. menopause.org/docs/agm/general-release.pdf?sfvrsn=0 [accessed 2 February 2013].
17. Schierbeck LL, Rejnmark L, Tofteng CL, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomized trial. BMJ 2012;345:e6409.
18. Panay N, Fenton A. Has the time for the definitive, randomized, placebo-controlled HRT trial arrived? Climacteric 2011;14:195-196.
19. British Menopause Society Council. Modernizing the NHS: observations and recommendations from the British Menopause Society. Menopause Int 2011;17:41-43.