-
1
-
-
78751477191
-
Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
-
Huntzinger, E. and Izaurralde, E. (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet., 12, 99-110.
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 99-110
-
-
Huntzinger, E.1
Izaurralde, E.2
-
2
-
-
84861866572
-
The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC
-
Fabian, M.R. and Sonenberg, N. (2012) The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat. Struct. Mol. Biol., 19, 586-593.
-
(2012)
Nat. Struct. Mol. Biol
, vol.19
, pp. 586-593
-
-
Fabian, M.R.1
Sonenberg, N.2
-
3
-
-
70349177026
-
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
-
Fabian, M.R., Mathonnet, G., Sundermeier, T., Mathys, H., Zipprich, J.T., Svitkin, Y.V., Rivas, F., Jinek, M., Wohlschlegel, J., Doudna, J.A. et al. (2009) Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol. Cell, 35, 868-880.
-
(2009)
Mol. Cell
, vol.35
, pp. 868-880
-
-
Fabian, M.R.1
Mathonnet, G.2
Sundermeier, T.3
Mathys, H.4
Zipprich, J.T.5
Svitkin, Y.V.6
Rivas, F.7
Jinek, M.8
Wohlschlegel, J.9
Doudna, J.A.10
-
4
-
-
71949121493
-
The silencing domain of GW182 interacts with PABP to promote translational repression and degradation of miRNA targets and is required for target release
-
Zekri, L., Huntzinger, E., Heimstadt, S. and Izaurralde, E. (2009) The silencing domain of GW182 interacts with PABP to promote translational repression and degradation of miRNA targets and is required for target release. Mol. Cell. Biol., 29, 6220-6231.
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 6220-6231
-
-
Zekri, L.1
Huntzinger, E.2
Heimstadt, S.3
Izaurralde, E.4
-
5
-
-
78650258635
-
Two PABP-binding sites in GW182 proteins promote miRNA-mediated gene silencing
-
Huntzinger, E., Braun, J.E., Heimstadt, S., Zekri, L. and Izaurralde, E. (2010) Two PABP-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J., 29, 4146-4160.
-
(2010)
EMBO J
, vol.29
, pp. 4146-4160
-
-
Huntzinger, E.1
Braun, J.E.2
Heimstadt, S.3
Zekri, L.4
Izaurralde, E.5
-
6
-
-
76349104822
-
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
-
Jnek, M., Fabian, M.R., Coyle, S.M., Sonenberg, N. and Doudna, J.A. (2010) Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat. Struct. Mol. Biol., 17, 238-240.
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 238-240
-
-
Jnek, M.1
Fabian, M.R.2
Coyle, S.M.3
Sonenberg, N.4
Doudna, J.A.5
-
7
-
-
77951596454
-
Structural basis of binding of P-body associated protein GW182 and Ataxin-2 by the MLLE domain of poly(A)-binding protein
-
Kozlov, G., Safaee, N., Rosenauer, A. and Gehrin, K. (2010) Structural basis of binding of P-body associated protein GW182 and Ataxin-2 by the MLLE domain of poly(A)-binding protein. J. Biol. Chem., 285, 13599-13606.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 13599-13606
-
-
Kozlov, G.1
Safaee, N.2
Rosenauer, A.3
Gehrin, K.4
-
8
-
-
80053580757
-
GW182 proteins recruit cytoplasmic deadenylase complexes to miRNA targets
-
Braun, J.E., Huntzinger, E., Fauser, M. and Izaurralde, E. (2011) GW182 proteins recruit cytoplasmic deadenylase complexes to miRNA targets. Mol. Cell, 44, 120-133.
-
(2011)
Mol. Cell
, vol.44
, pp. 120-133
-
-
Braun, J.E.1
Huntzinger, E.2
Fauser, M.3
Izaurralde, E.4
-
9
-
-
80555131046
-
MiRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs
-
Chekulaeva, M., Mathys, H., Zipprich, J.T., Attig, J., Colic, M., Parker, R. and Filipowicz, W. (2011) miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat. Struct. Mol. Biol., 18, 1218-1226.
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1218-1226
-
-
Chekulaeva, M.1
Mathys, H.2
Zipprich, J.T.3
Attig, J.4
Colic, M.5
Parker, R.6
Filipowicz, W.7
-
10
-
-
80555150587
-
MiRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT
-
Fabian, M.R., Cieplak, M.K., Frank, F., Morita, M., Green, J., Srikumar, T., Nagar, B., Yamamoto, T., Raught, B., Duchaine, T.F. et al. (2011) miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat. Struct. Mol. Biol., 18, 1211-1217.
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1211-1217
-
-
Fabian, M.R.1
Cieplak, M.K.2
Frank, F.3
Morita, M.4
Green, J.5
Srikumar, T.6
Nagar, B.7
Yamamoto, T.8
Raught, B.9
Duchaine, T.F.10
-
11
-
-
65249161794
-
Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila
-
Chekulaeva, M., Filipowicz, W. and Parker, R. (2009) Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA, 15, 794-803.
-
(2009)
RNA
, vol.15
, pp. 794-803
-
-
Chekulaeva, M.1
Filipowicz, W.2
Parker, R.3
-
12
-
-
66449124170
-
A C-terminal silencing domain in GW182 is essential for miRNA function
-
Eulalio, A., Helms, S., Fritzsch, C., Fauser, M. and Izaurralde, E. (2009) A C-terminal silencing domain in GW182 is essential for miRNA function. RNA, 15, 1067-1077.
-
(2009)
RNA
, vol.15
, pp. 1067-1077
-
-
Eulalio, A.1
Helms, S.2
Fritzsch, C.3
Fauser, M.4
Izaurralde, E.5
-
13
-
-
77956503398
-
Translational repression by deadenylases
-
Cooke, A., Prigge, A. and Wickens, M. (2010) Translational repression by deadenylases. J. Biol. Chem., 285, 28506-28513.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 28506-28513
-
-
Cooke, A.1
Prigge, A.2
Wickens, M.3
-
14
-
-
33746055678
-
MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
-
DOI 10.1101/gad.1424106
-
Behm-Ansmant, I., Rehwinkel, J., Doerks, T., Stark, A., Bork, P. and Izaurralde, E. (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev., 20, 1885-1898. (Pubitemid 44079326)
-
(2006)
Genes and Development
, vol.20
, Issue.14
, pp. 1885-1898
-
-
Behm-Ansmant, I.1
Rehwinkel, J.2
Doerks, T.3
Stark, A.4
Bork, P.5
Izaurralde, E.6
-
15
-
-
84864872623
-
Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells
-
Bethune, J., Artus-Revel, C.G. and Filipowicz, W. (2012) Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep., 13, 716-723.
-
(2012)
EMBO Rep
, vol.13
, pp. 716-723
-
-
Bethune, J.1
Artus-Revel, C.G.2
Filipowicz, W.3
-
16
-
-
84862778053
-
Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish
-
Bazzini, A.A., Lee, M.T. and Giraldez, A.J. (2012) Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science, 336, 233-237.
-
(2012)
Science
, vol.336
, pp. 233-237
-
-
Bazzini, A.A.1
Lee, M.T.2
Giraldez, A.J.3
-
17
-
-
84859632747
-
MiRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay
-
Djuranovic, S., Nahvi, A. and Green, A. (2012) miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science, 336, 237-240.
-
(2012)
Science
, vol.336
, pp. 237-240
-
-
Djuranovic, S.1
Nahvi, A.2
Green, A.3
-
18
-
-
34547944309
-
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
-
DOI 10.1126/science.1146067
-
Mathonnet, G., Fabian, M.R., Svitkin, Y.V., Parsyan, A., Huck, L., Murata, T., Biffo, S., Merrick, W.C., Darzynkiewicz, E., Pillai, R.S. et al. (2007) MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science, 17, 1764-1767. (Pubitemid 47461843)
-
(2007)
Science
, vol.317
, Issue.5845
, pp. 1764-1767
-
-
Mathonnet, G.1
Fabian, M.R.2
Svitkin, Y.V.3
Parsyan, A.4
Huck, L.5
Murata, T.6
Biffo, S.7
Merrick, W.C.8
Darzynkiewicz, E.9
Pillai, R.S.10
Filipowicz, W.11
Duchaine, T.F.12
Sonenberg, N.13
-
19
-
-
70349189317
-
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression
-
Zdanowicz, A., Thermann, R., Kowalska, J., Jemielity, J., Duncan, K., Preiss, T., Darzynkiewicz, E. and Hentze, M.W. (2009) Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol. Cell, 35, 881-888.
-
(2009)
Mol. Cell
, vol.35
, pp. 881-888
-
-
Zdanowicz, A.1
Thermann, R.2
Kowalska, J.3
Jemielity, J.4
Duncan, K.5
Preiss, T.6
Darzynkiewicz, E.7
Hentze, M.W.8
-
20
-
-
35348962568
-
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing
-
DOI 10.1101/gad.443107
-
Eulalio, A., Rehwinkel, J., Stricker, M., Huntzinger, E., Yang, S.F., Doerks, T., Dorner, S., Bork, P., Boutros, M. and Izaurralde, E. (2007) Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev., 21, 2558-2570. (Pubitemid 47607667)
-
(2007)
Genes and Development
, vol.21
, Issue.20
, pp. 2558-2570
-
-
Eulalio, A.1
Rehwinkel, J.2
Stricker, M.3
Huntzinger, E.4
Yang, S.-F.5
Doerks, T.6
Dorner, S.7
Bork, P.8
Boutros, M.9
Izaurralde, E.10
-
21
-
-
58149103297
-
Deadenylation is a widespread effect of miRNA regulation
-
Eulalio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M. and Izaurralde, E. (2009) Deadenylation is a widespread effect of miRNA regulation. RNA, 15, 21-32.
-
(2009)
RNA
, vol.15
, pp. 21-32
-
-
Eulalio, A.1
Huntzinger, E.2
Nishihara, T.3
Rehwinkel, J.4
Fauser, M.5
Izaurralde, E.6
-
22
-
-
24644480213
-
Molecular biology: Inhibition of translational initiation by let-7 microRNA in human cells
-
DOI 10.1126/science.1115079
-
Pillai, R.S., Bhattacharyya, S.N., Artus, C.G., Zoller, T., Cougot, N., Basyuk, E., Bertrand, E. and Filipowicz, W. (2005) Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science, 309, 1573-1576. (Pubitemid 41266485)
-
(2005)
Science
, vol.309
, Issue.5740
, pp. 1573-1576
-
-
Pillai, R.S.1
Bhattacharyya, S.N.2
Artus, C.G.3
Zoller, T.4
Cougot, N.5
Basyuk, E.6
Bertrand, E.7
Filipowicz, W.8
-
23
-
-
33947431322
-
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
-
DOI 10.1126/science.1137999
-
Mayr, C., Hemann, M.T. and Bartel, D.P. (2007) Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science, 315, 1576-1579. (Pubitemid 46449474)
-
(2007)
Science
, vol.315
, Issue.5818
, pp. 1576-1579
-
-
Mayr, C.1
Hemann, M.T.2
Bartel, D.P.3
-
24
-
-
3543016170
-
A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila
-
DOI 10.1038/sj.emboj.7600273
-
Temme, C., Zaessinger, S., Meyer, S., Simonelig, M. and Wahle, E. (2004) A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila. EMBO J., 23, 2862-2871. (Pubitemid 39013558)
-
(2004)
EMBO Journal
, vol.23
, Issue.14
, pp. 2862-2871
-
-
Temme, C.1
Zaessinger, S.2
Meyer, S.3
Simonelig, M.4
Wahle, E.5
-
25
-
-
78049393669
-
The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression
-
Chekulaeva, M., Parker, R. and Filipowicz, W. (2010) The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression. Nucleic Acids Res., 38, 6673-6683.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 6673-6683
-
-
Chekulaeva, M.1
Parker, R.2
Filipowicz, W.3
-
26
-
-
83555161676
-
PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro
-
Fukaya, T. and Tomari, Y. (2011) PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro. EMBO J., 30, 4998-5009.
-
(2011)
EMBO J
, vol.30
, pp. 4998-5009
-
-
Fukaya, T.1
Tomari, Y.2
-
27
-
-
79954610487
-
Divergent GW182 functional domains in the regulation of translational silencing
-
Yao, B., Li, S., Jung, H.M., Lian, S.L., Abadal, G.X., Han, F., Fritzler, M.J. and Chan, E.K. (2011) Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res., 39, 2534-2547.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 2534-2547
-
-
Yao, B.1
Li, S.2
Jung, H.M.3
Lian, S.L.4
Abadal, G.X.5
Han, F.6
Fritzler, M.J.7
Chan, E.K.8
-
28
-
-
41649115420
-
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay
-
DOI 10.1038/nsmb.1405, PII NSMB1405
-
Eulalio, A., Huntzinger, E. and Izaurralde, E. (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat. Struct. Mol. Biol., 15, 346-353. (Pubitemid 351483394)
-
(2008)
Nature Structural and Molecular Biology
, vol.15
, Issue.4
, pp. 346-353
-
-
Eulalio, A.1
Huntzinger, E.2
Izaurralde, E.3
-
29
-
-
84861854141
-
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes
-
Kuzuoglu-Ozturk, D., Huntzinger, E., Schmidt, S. and Izaurralde, E. (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res., 40, 5651-5665.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 5651-5665
-
-
Kuzuoglu-Ozturk, D.1
Huntzinger, E.2
Schmidt, S.3
Izaurralde, E.4
-
30
-
-
84856375470
-
Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish
-
Mishima, Y., Fukao, A., Kishimoto, T., Sakamoto, H., Fujiwara, T. and Inoue, K. (2012) Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Proc. Natl Acad. Sci. USA, 109, 1104-1109.
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 1104-1109
-
-
Mishima, Y.1
Fukao, A.2
Kishimoto, T.3
Sakamoto, H.4
Fujiwara, T.5
Inoue, K.6
-
31
-
-
84870622730
-
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex
-
Petit, A.P., Wohlbold, L., Bawankar, P., Huntzinger, E., Schmidt, S., Izaurralde, E. and Weichenrieder, O. (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res, 40, 11058-11072.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 11058-11072
-
-
Petit, A.P.1
Wohlbold, L.2
Bawankar, P.3
Huntzinger, E.4
Schmidt, S.5
Izaurralde, E.6
Weichenrieder, O.7
-
32
-
-
70350780068
-
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
-
Chen, C.Y., Zheng, D., Xia, Z. and Shyu, A.B. (2009) Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps. Nat. Struct. Mol. Biol., 16, 1160-1166.
-
(2009)
Nat. Struct. Mol. Biol
, vol.16
, pp. 1160-1166
-
-
Chen, C.Y.1
Zheng, D.2
Xia, Z.3
Shyu, A.B.4
-
33
-
-
77749334621
-
CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells
-
Piao, X., Zhang, X., Wu, L. and Belasco, J.G. (2010) CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells. Mol. Cell. Biol, 30, 1486-1494.
-
(2010)
Mol. Cell. Biol
, vol.30
, pp. 1486-1494
-
-
Piao, X.1
Zhang, X.2
Wu, L.3
Belasco, J.G.4
-
34
-
-
75649096055
-
Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression
-
Walters, R.W., Bradrick, S.S. and Gromeier, M. (2010) Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. RNA, 16, 239-250.
-
(2010)
RNA
, vol.16
, pp. 239-250
-
-
Walters, R.W.1
Bradrick, S.S.2
Gromeier, M.3
-
35
-
-
84861839851
-
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
-
Moretti, F., Kaiser, C., Zdanowicz-Specht, A. and Hentze, M.W. (2012) PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat. Struct. Mol. Biol., 19, 603-608.
-
(2012)
Nat. Struct. Mol. Biol
, vol.19
, pp. 603-608
-
-
Moretti, F.1
Kaiser, C.2
Zdanowicz-Specht, A.3
Hentze, M.W.4
-
36
-
-
84155195139
-
The Ccr4-not complex
-
Collart, M.A. and Panasenko, O.O. (2012) The Ccr4-not complex. Gene, 492, 42-53.
-
(2012)
Gene
, vol.492
, pp. 42-53
-
-
Collart, M.A.1
Panasenko, O.O.2
-
37
-
-
34548359334
-
Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein
-
DOI 10.1074/jbc.M701256200
-
Siddiqui, N., Mangus, D.A., Chang, T.C., Palermino, J.M., Shyu, A.B. and Gehring, K. (2007) Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. J. Biol. Chem., 282, 25067-25075. (Pubitemid 47347518)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.34
, pp. 25067-25075
-
-
Siddiqui, N.1
Mangus, D.A.2
Chang, T.-C.3
Palermino, J.-M.4
Shyu, A.-B.5
Gehring, K.6
-
38
-
-
47549087539
-
Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells
-
DOI 10.1083/jcb.200801196
-
Zheng, D., Ezzeddine, N., Chen, C.Y., Zhu, W., He, X. and Shyu, A.B. (2008) Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J. Cell. Biol., 182, 89-101. (Pubitemid 352008624)
-
(2008)
Journal of Cell Biology
, vol.182
, Issue.1
, pp. 89-101
-
-
Zheng, D.1
Ezzeddine, N.2
Chen, C.-Y.A.3
Zhu, W.4
He, X.5
Shyu, A.-B.6
-
39
-
-
65249083468
-
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression
-
Zipprich, J.T., Bhattacharyya, S., Mathys, H. and Filipowicz, W. (2009) Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA, 15, 781-793.
-
(2009)
RNA
, vol.15
, pp. 781-793
-
-
Zipprich, J.T.1
Bhattacharyya, S.2
Mathys, H.3
Filipowicz, W.4
-
40
-
-
66449123316
-
The C-terminal domains of human TNRC6A, B and C silence bound transcripts independently of the Argonaute proteins
-
Lazzaretti, D., Tournier, I. and Izaurralde, E. (2009) The C-terminal domains of human TNRC6A, B and C silence bound transcripts independently of the Argonaute proteins. RNA, 15, 1059-1066.
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(2009)
RNA
, vol.15
, pp. 1059-1066
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Lazzaretti, D.1
Tournier, I.2
Izaurralde, E.3
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