Leishmania donovani targets dicer1 to downregulate miR-122, lower serum cholesterol, and facilitate murine liver infection

Cell Host and Microbe

Volumn 13, Issue 3, 2013, Pages 277-288

  Ghosh, June ^a   Bose, Mainak ^a   Roy, Syamal ^a   Bhattacharyya, Suvendra N ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DICER; DICER1 PROTEIN; GLYCOPROTEIN; GLYCOPROTEIN GP63 PROTEIN; METALLOPROTEINASE; MICRORNA 122; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; GENE ACTIVITY; GENETIC ASSOCIATION; HEPATITIS; INFECTION RESISTANCE; INTERNALIZATION; LEISHMANIA DONOVANI; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE LOAD; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; VISCERAL LEISHMANIASIS;

EID: 84875169603     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2013.02.005     Document Type: Article

References (35)

1. F. Andrianaivo, M. Lecocq, S. Wattiaux-De Coninck, R. Wattiaux, and M. Jadot Hydrodynamics-based transfection of the liver: entrance into hepatocytes of DNA that causes expression takes place very early after injection J. Gene Med. 6 2004 877 883
2. S. Banerjee, J. Ghosh, S. Sen, R. Guha, R. Dhar, M. Ghosh, S. Datta, B. Raychaudhury, K. Naskar, and A.K. Haldar Designing therapies against experimental visceral leishmaniasis by modulating the membrane fluidity of antigen-presenting cells Infect. Immun. 77 2009 2330 2342
3. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
4. L. Beattie, A. Peltan, A. Maroof, A. Kirby, N. Brown, M. Coles, D.F. Smith, and P.M. Kaye Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells PLoS Pathog. 6 2010 e1000805
5. C. Belair, J. Baud, S. Chabas, C.M. Sharma, J. Vogel, C. Staedel, and F. Darfeuille Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Silence 2 2011 7
6. A. Benito, J.X. Feliu, and A. Villaverde Beta-galactosidase enzymatic activity as a molecular probe to detect specific antibodies J. Biol. Chem. 271 1996 21251 21256
7. S. Bhatnagar, K. Shinagawa, F.J. Castellino, and J.S. Schorey Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo Blood 110 2007 3234 3244
8. S. Bhowmick, R. Ravindran, and N. Ali gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani Infect. Immun. 76 2008 1003 1015
9. A. Brittingham, C.J. Morrison, W.R. McMaster, B.S. McGwire, K.P. Chang, and D.M. Mosser Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis J. Immunol. 155 1995 3102 3111
10. D. Cazalla, T. Yario, and J.A. Steitz Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA Science 328 2010 1563 1566
11. D. Chakraborty, S. Banerjee, A. Sen, K.K. Banerjee, P. Das, and S. Roy Leishmania donovani affects antigen presentation of macrophage by disrupting lipid rafts J. Immunol. 175 2005 3214 3224
12. J. Chang, E. Nicolas, D. Marks, C. Sander, A. Lerro, M.A. Buendia, C. Xu, W.S. Mason, T. Moloshok, and R. Bort miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1 RNA Biol. 1 2004 106 113
13. J.A. Cooper, and C.S. King Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src Mol. Cell. Biol. 6 1986 4467 4477
14. S.L. Croft, S. Sundar, and A.H. Fairlamb Drug resistance in leishmaniasis Clin. Microbiol. Rev. 19 2006 111 126
15. M. Desjardins, and A. Descoteaux Survival strategies of Leishmania donovani in mammalian host macrophages Res. Immunol. 149 1998 689 692
16. A.C. Durieux, A. Vignaud, B. Prudhon, M.T. Viou, M. Beuvin, S. Vassilopoulos, B. Fraysse, A. Ferry, J. Lainé, and N.B. Romero A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice Hum. Mol. Genet. 19 2010 4820 4836
17. J. Elmén, M. Lindow, A. Silahtaroglu, M. Bak, M. Christensen, A. Lind-Thomsen, M. Hedtjärn, J.B. Hansen, H.F. Hansen, and E.M. Straarup Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver Nucleic Acids Res. 36 2008 1153 1162
18. C.R. Engwerda, M. Ato, and P.M. Kaye Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis Trends Parasitol. 20 2004 524 530
19. C. Esau, S. Davis, S.F. Murray, X.X. Yu, S.K. Pandey, M. Pear, L. Watts, S.L. Booten, M. Graham, and R. McKay miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab. 3 2006 87 98
20. W. Filipowicz, S.N. Bhattacharyya, and N. Sonenberg Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9 2008 102 114
21. J. Ghosh, C.S. Lal, K. Pandey, V.N. Das, P. Das, K. Roychoudhury, and S. Roy Human visceral leishmaniasis: decrease in serum cholesterol as a function of splenic parasite load Ann. Trop. Med. Parasitol. 105 2011 267 271
22. J. Ghosh, S. Das, R. Guha, D. Ghosh, K. Naskar, A. Das, and S. Roy Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol J. Lipid Res. 53 2012 2560 2572
23. M. Girard, E. Jacquemin, A. Munnich, S. Lyonnet, and A. Henrion-Caude miR-122, a paradigm for the role of microRNAs in the liver J. Hepatol. 48 2008 648 656
24. M. Hallé, M.A. Gomez, M. Stuible, H. Shimizu, W.R. McMaster, M. Olivier, and M.L. Tremblay The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation J. Biol. Chem. 284 2009 6893 6908
25. M. Jaramillo, M.A. Gomez, O. Larsson, M.T. Shio, I. Topisirovic, I. Contreras, R. Luxenburg, A. Rosenfeld, R. Colina, and R.W. McMaster Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection Cell Host Microbe 9 2011 331 341
26. J. Krützfeldt, and M. Stoffel MicroRNAs: a new class of regulatory genes affecting metabolism Cell Metab. 4 2006 9 12
27. C.S. Lal, A. Kumar, S. Kumar, K. Pandey, N. Kumar, S. Bimal, P.K. Sinha, and P. Das Hypocholesterolemia and increased triglyceride in pediatric visceral leishmaniasis Clin. Chim. Acta 382 2007 151 153
28. E. Liberopoulos, G. Alexandridis, E. Bairaktari, and M. Elisaf Severe hypocholesterolemia with reduced serum lipoprotein(a) in a patient with visceral leishmaniasis Ann. Clin. Lab. Sci. 32 2002 305 308
29. V. Libri, A. Helwak, P. Miesen, D. Santhakumar, J.G. Borger, G. Kudla, F. Grey, D. Tollervey, and A.H. Buck Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target Proc. Natl. Acad. Sci. USA 109 2012 279 284
30. H.W. Murray, J.D. Berman, C.R. Davies, and N.G. Saravia Advances in leishmaniasis Lancet 366 2005 1561 1577
31. M. Olivier, D.J. Gregory, and G. Forget Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view Clin. Microbiol. Rev. 18 2005 293 305
32. G. Raposo, H.W. Nijman, W. Stoorvogel, R. Liejendekker, C.V. Harding, C.J. Melief, and H.J. Geuze B lymphocytes secrete antigen-presenting vesicles J. Exp. Med. 183 1996 1161 1172
33. B. Saha, H. Nanda-Roy, A. Pakrashi, R.N. Chakrabarti, and S. Roy Immunobiological studies on experimental visceral leishmaniasis. I. Changes in lymphoid organs and their possible role in pathogenesis Eur. J. Immunol. 21 1991 577 581
34. J.M. Silverman, J. Clos, C.C. de'Oliveira, O. Shirvani, Y. Fang, C. Wang, L.J. Foster, and N.E. Reiner An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages J. Cell Sci. 123 2010 842 852
35. M. Tada, E. Hatano, K. Taura, T. Nitta, N. Koizumi, I. Ikai, and Y. Shimahara High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine J. Gene Med. 8 2006 1018 1026