Doxycycline use in patients with lymphangioleiomyomatosis: Biomarkers and pulmonary function response;Doxiciclina em pacientes com linfangioleiomiomatose: Biomarcadores e resposta funcional pulmonar

Jornal Brasileiro de Pneumologia

Volumn 39, Issue 1, 2013, Pages 5-15

  Pimenta, Suzana Pinheiro ^a   Baldi, Bruno Guedes ^b   Kairalla, Ronaldo Adib ^b   Carvalho, Carlos Roberto Ribeiro ^b  

^a A C CAMARGO CANCER CENTER   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Doxycycline; Lymphangioleiomyomatosis; Matrix metalloproteinases; Respiratory function tests

Indexed keywords

EID: 84875141583     PISSN: 18063713     EISSN: 18063756     Source Type: Journal    
DOI: 10.1590/S1806-37132013000100002     Document Type: Article

References (41)

1. Costello LC, Hartman TE, Ryu JH. High frequency of pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex. Mayo Clin Proc. 2000;75(6):591-4. PMid:10852420. http://dx.doi.org/10.4065/75.6.591
2. Chu SC, Horiba K, Usuki J, Avila NA, Chen CC, Travis WD, et al. Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest. 1999;115(4):1041-52. PMid:10208206. http://dx.doi.org/10.1378/chest.115.4.1041
3. Taveira-DaSilva AM, Steagall WK, Moss J. Lymphangioleiomyomatosis. Cancer Control. 2006;13(4):276-85.
4. Johnson SR, Tattersfield AE. Clinical experience of lymphangioleiomyomatosis in the UK. Thorax. 2000;55(12):1052-7. PMCid:1745654. http://dx.doi.org/10.1136/thorax.55.12.1052
5. Taylor JR, Ryu J, Colby TV, Raffin TA. Lymphangioleiomyomatosis. Clinical course in 32 patients. N Engl J Med. 19901;323(18):1254-60.
6. Baldi BG, Pimenta SP, Kawassaki Ade M, Bernardi Fdel C, Dolhnikoff M, Carvalho CR. Pulmonary arterial involvement leading to alveolar hemorrhage in lymphangioleiomyomatosis. Clinics (Sao Paulo). 2011;66(7):1301-3. PMCid:3148482. http://dx.doi.org/10.1590/S1807-59322011000700031
7. Ryu JH, Moss J, Beck GJ, Lee JC, Brown KK, Chapman JT, et al. The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment. Am J Respir Crit Care Med. 2006;173(1):105-11. PMid:16210669 PMCid:2662978. http://dx.doi.org/10.1164/rccm.200409-1298OC
8. Taveira-DaSilva AM, Stylianou MP, Hedin CJ, Hathaway O, Moss J. Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone. Chest. 2004;126(6):1867-74. PMid:15596686. http://dx.doi.org/10.1378/chest.126.6.1867
9. Baldi BG, Medeiros Junior P, Pimenta SP, Lopes RI, Kairalla RA, Carvalho CR. Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis. J Bras Pneumol. 2011;37(3):375-9. PMid:21755194. http://dx.doi.org/10.1590/S1806-37132011000300015
10. Harari S, Cassandro R, Chiodini I, Taveira-DaSilva AM, Moss J. Effect of a gonadotrophin-releasing hormone analogue on lung function in lymphangioleiomyomatosis. Chest. 2008;133(2):448-54. Erratum in: Chest. 2009;136(2):653. PMid:18071009 PMCid:2946894. http://dx.doi.org/10.1378/chest.07-2277
11. McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011;364(17):1595-606. PMid:21410393 PMCid:3118601. http://dx.doi.org/10.1056/NEJMoa1100391
12. Matsui K, Takeda K, Yu ZX, Travis WD, Moss J, Ferrans VJ. Role for activation of matrix metalloproteinases in the pathogenesis of pulmonary lymphangioleiomyomatosis. Arch Pathol Lab Med. 2000;124(2):267-75. PMid:10656737.
13. Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M. Matrix metalloproteinases in blood from patients with LAM. Respir Med. 2009;103(1):124-9. PMid:18760908. http://dx.doi.org/10.1016/j.rmed.2008.07.017
14. Ji RC. Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix. Lymphat Res Biol. 2006;4(2):83-100. PMid:16808670. http://dx.doi.org/10.1089/lrb.2006.4.83
15. Vignola AM, Paganin F, Capieu L, Scichilone N, Bellia M, Maakel L, et al. Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD. Eur Respir J. 2004;24(6):910-7. PMid:15572531. http://dx.doi.org/10.1183/09031936.04.00032603
16. Hayashi T, Rush WL, Travis WD, Liotta LA, Stetler-Stevenson WG, Ferrans VJ. Immunohistochemical study of matrix metalloproteinases and their tissue inhibitors in pulmonary Langerhans' cell granulomatosis. Arch Pathol Lab Med. 1997;121(9):930-7. PMid:9302924.
17. Fukuda Y, Kawamoto M, Yamamoto A, Ishizaki M, Basset F, Masugi Y. Role of elastic fiber degradation in emphysema-like lesions of pulmonary lymphangiomyomatosis. Hum Pathol. 1990;21(12):1252-61. http://dx.doi.org/10.1016/S0046-8177(06)80039-0
18. Hayashi T, Fleming MV, Stetler-Stevenson WG, Liotta LA, Moss J, Ferrans VJ, et al. Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM). Hum Pathol. 1997;28(9):1071-8. http://dx.doi.org/10.1016/S0046-8177(97)90061-7
19. Moses MA, Harper J, Folkman J. Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs. N Engl J Med. 2006;354(24):2621-2. PMid:16775248. http://dx.doi.org/10.1056/NEJMc053410
20. Pimenta SP, Baldi BG, Acencio MM, Kairalla RA, Carvalho CR. Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade. J Bras Pneumol. 2011;37(4):424-30. PMid:21881731. http://dx.doi.org/10.1590/S1806-37132011000400003
21. Johnson SR, Cordier JF, Lazor R, Cottin V, Costabel U, Harari S, et al. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J. 2010;35(1):14-26. PMid:20044458. http://dx.doi.org/10.1183/09031936.00076209
22. Rubin AS, Santana AN, Costa AN, Baldi BG, Pereira, CA, Carvalho CR, et al. Diretrizes de doenças pulmonares intersticiais da Sociedade Brasileira de Pneumologia e Tisiologia. J Bras Pneumol. 2012;38(Suppl 2): S1-S133.
23. Pereira CA, Sato T, Rodrigues SC. New reference values for forced spirometry in white adults in Brazil. J Bras Pneumol. 2007;33(4):397-406. PMid:17982531. http://dx.doi.org/10.1590/S1806-37132007000400008
24. Neder JA, Andreoni S, Castelo-Filho A, Nery LE. Reference values for lung function tests. I. Static volumes. Braz J Med Biol Res. 1999;32(6):703-17. PMid:10412549.
25. Neder JA, Andreoni S, Peres C, Nery LE. Reference values for lung function tests. III. Carbon monoxide diffusing capacity (transfer factor). Braz J Med Biol Res. 1999;32(6):729-37. PMid:10412551. http://dx.doi.org/10.1590/S0100-879X1999000600008
26. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111-7. PMid:12091180.
27. Soaresa MR, Pereira CA. Six-minute walk test: reference values for healthy adults in Brazil. J Bras Pneumol. 2011;37(5):576-83. PMid:22042388. http://dx.doi.org/10.1590/S1806-37132011000500003
28. Zimmermann CS, Carvalho CR, Silveira KR, Yamaguti WP, Moderno EV, Salge JM, et al. Comparison of two questionnaires which measure the health-related quality of life of idiopathic pulmonary fibrosis patients. Braz J Med Biol Res. 2007;40(2):179-87. PMid:17273654. http://dx.doi.org/10.1590/S0100-879X2006005000056
29. Ciconelli RM, Ferraz MB, Santos W, Meinão I, Quaresma MR. Tradução para língua portuguesa e validação do questionário genérico de de avaliação de qualidade de vida SF-36 (Brasil SF-36). Rev Bras Reumatol. 1999;39:143-50.
30. Chang WY, Clements D, Johnson SR. Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells. Am J Physiol Lung Cell Mol Physiol. 2010;299(3):L393-400. PMid:20581100. http://dx.doi.org/10.1152/ajplung.00437.2009
31. Moir LM, Ng HY, Poniris MH, Santa T, Burgess JK, Oliver BG, et al. Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells. Br J Pharmacol. 2011;164(1):83-92. PMid:21418186 PMCid:3171862. http://dx.doi.org/10.1111/j.1476-5381.2011.01344.x
32. Lee CZ, Xu B, Hashimoto T, McCulloch CE, Yang GY, Young WL. Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke. 2004;35(7):1715-9. PMid:15166398. http://dx.doi.org/10.1161/01.STR.0000129334.05181.b6
33. Chung AW, Yang HH, Radomski MW, van Breemen C. Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and-9. Circ Res. 2008;102(8):e73-85. PMid:18388324. http://dx.doi.org/10.1161/CIRCRESAHA.108.174367
34. Steagall WK, Glasgow CG, Hathaway OM, Avila NA, Taveira-Dasilva AM, Rabel A, et al. Genetic and morphologic determinants of pneumothorax in lymphangioleiomyomatosis. Am J Physiol Lung Cell Mol Physiol. 2007;293(3):L800-8. PMid:17616646. http://dx.doi.org/10.1152/ajplung.00176.2007
35. Yao JS, Shen F, Young WL, Yang GY. Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration. Neurochem Int. 2007;50(3):524-30. PMid:17145119 PMCid:1876824. http://dx.doi.org/10.1016/j.neuint.2006.10.008
36. Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'Amato R, et al. Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J. 2008;22(10):3728-35. PMid:18606869. http://dx.doi.org/10.1096/fj.08-110494
37. Gilbertson-Beadling S, Powers EA, Stamp-Cole M, Scott PS, Wallace TL, Copeland J, et al. The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism. Cancer Chemother Pharmacol. 1995;36(5):418-24. PMid:7543375. http://dx.doi.org/10.1007/BF00686191
38. Glasgow CG, Avila NA, Lin JP, Stylianou MP, Moss J. Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement. Chest. 2009;135(5):1293-300. PMid:19420197 PMCid:2818417. http://dx.doi.org/10.1378/chest.08-1160
39. Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, et al. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest. 2010;138(3):674-81. PMid:20382711 PMCid:2940071. http://dx.doi.org/10.1378/chest.10-0573
40. Chang WY, Cane JL, Blakey JD, Kumaran M, Pointon KS, Johnson SR. Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis. Respir Res. 2012;13:34. PMid:22513045 PMCid:3431996. http://dx.doi.org/10.1186/1465-9921-13-34
41. Johnson SR, Tattersfield AE. Decline in lung function in lymphangioleiomyomatosis: relation to menopause and progesterone treatment. Am J Respir Crit Care Med. 1999;160(2):628-33. PMid:10430739.