News on the genetics of lipoprotein metabolism and cardiovascular disease

Current Opinion in Lipidology

Volumn 24, Issue 2, 2013, Pages 185-186

  Van De Sluis, Bart ^a   Kuivenhoven, Jan ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HEPATOCYTE NUCLEAR FACTOR 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ALLELE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ENVIRONMENTAL FACTOR; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HEREDITY; HUMAN; LIFESTYLE; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MENDELIAN RANDOMIZATION ANALYSIS; NOTE; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LIPID METABOLISM; RISK FACTORS; TRIGLYCERIDES;

EID: 84875141072     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32835ec621     Document Type: Note

References (10)

1. Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study. Lancet 2012; 380: 572-580. This study underscores that Mendelian randomization approaches do not support the HDL hypothesis.
2. Vergeer M, Holleboom AG, Kastelein JJ, Kuivenhoven JA. The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? J Lipid Res 2010; 51: 2058-2073.
3. Chapman MJ, Ginsberg HN, Amarenco P, et al., European Atherosclerosis Society Consensus Panel. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011; 32: 1345-1361.
4. Rader DJ, Tall AR. The not-so-simple HDL story: is it time to revise the HDL cholesterol hypothesis? Nat Med 2012; 18: 1344-1346.
5. Asselbergs FW, Guo Y, van Iperen EP, et al. Large-scale gene-centric metaanalysis across 32 studies identifies multiple lipid loci. Am J Hum Genet 2012; 91: 823-838. This study shows gene-centric genotyping may permit a better identification of multiple functional polymorphisms, or their proxies, at each locus.
6. Deloukas P, Kanoni S, Willenborg C, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012; 45: 25-33. This study shows that bioinformatic network analyses may help us interpreting GWAS data.
7. Kettunen J, Tukiainen T, Sarin AP, et al. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 2012; 44: 269-276.
8. Suhre K, Gieger C. Genetic variation in metabolic phenotypes: study designs and applications. Nat Rev Genet 2012; 13: 759-769.
9. Johannsen TH, Frikke-Schmidt R, Schou J, et al. Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects. J Am Coll Cardiol 2012; 60: 2041-2048.
10. Quagliarini F, Wang Y, Kozlitina J, et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci USA 2012; 109: 19751-19756.