Is paracetamol hepatotoxic at normal doses?

BMJ (Online)

Volumn 346, Issue 7899, 2013, Pages

  Moore, Nicholas D ^a   Gulmez, Ezgi ^a   Blin, Patrick ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

DRUG OVERDOSE; HUMAN; LETTER; LIVER FAILURE; LIVER TRANSPLANTATION; PRIORITY JOURNAL; TOXIC HEPATITIS; UNITED KINGDOM;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EVIDENCE-BASED MEDICINE; GREAT BRITAIN; HUMANS; LIVER FAILURE, ACUTE; NONPRESCRIPTION DRUGS; TIME FACTORS;

EID: 84875134792     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f1519     Document Type: Letter

References (4)

1. Gulmez SE, Larrey D, Pageaux GP, Lignot S, Lassalle R, Jove J, et al. Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study. Drug Saf 2013; 36:135-44.
2. Hawton K, Bergen H, Simkin S, Dodd S, Pocock P, Bernal W, Gunnell D, Kapur N. Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses. BMJ 2013; 346:f403. (7 February.)
3. Moore N, Gulmez SE, Larrey D, Pageaux GP, Lignot S, Lassalle R, et al. Choice of the denominator in case population studies: event rates for registration for liver transplantation after exposure to NSAIDs in the SALT study in France. Pharmacoepidemiol Drug Saf 2013; 22:160-7.
4. Shaheen S, Potts J, Gnatiuc L, Makowska J, Kowalski ML, Joos G, et al. The relation between paracetamol use and asthma: a GA2LEN European case-control study. Eur Resp J 2008; 32:1231-6.