Expansion of a clonal CD8+CD57+ large granular lymphocyte population after autologous stem cell transplant in multiple myeloma

American Journal of Clinical Pathology

Volumn 139, Issue 2, 2013, Pages 231-241

  Wolniak, Kristy L ^a   Goolsby, Charles L ^a   Chen, Yi Hua ^a   Chenn, Anjen ^a   Singhal, Seema ^a   Mehta, Jayesh ^a   Peterson, LoAnn C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autologous stem cell transplant; Cytotoxic T cells; Flow cytometry; Hematopathology; Myeloma

Indexed keywords

CD57 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLOOD; BONE MARROW; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL LINEAGE; CONTROLLED STUDY; GENE REARRANGEMENT; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; LARGE GRANULAR LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; PRIORITY JOURNAL; AUTOTRANSPLANTATION; BONE MARROW CELL; CELL CLONE; CELL PROLIFERATION; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; LYMPHOCYTOSIS; METABOLISM; PATHOLOGY; POSTOPERATIVE COMPLICATION; STEM CELL TRANSPLANTATION;

ANTIGENS, CD57; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CLONE CELLS; FLOW CYTOMETRY; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; IMMUNITY, INNATE; IMMUNOPHENOTYPING; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; LYMPHOCYTOSIS; MULTIPLE MYELOMA; POSTOPERATIVE COMPLICATIONS; STEM CELL TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS;

MLCS; MLOWN;

EID: 84875070625     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP1T0JPBLSLAQF     Document Type: Article

References (21)

1. Au WY, Lam CC, Lie AK, et al. T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. Am J Clin Pathol. 2003;120:626-630.
2. Mohty M, Faucher C, Gaugler B, et al. Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: A case report. Bone Marrow Transplant. 2001;28:1157-1160.
3. Mohty M, Faucher C, Vey N, et al. Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: A long-term analysis. Leukemia. 2002;16:2129-2133.
4. Sabnani I, Zucker MJ, Tsang P, et al. Clonal T-large granular lymphocyte proliferation in solid organ transplant recipients. Transplant Proc. 2006;38:3437-3440.
5. Narumi H, Kojima K, Matsuo Y, et al. T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 2004;33:99-101.
6. Maggi F, Ricci V, Bendinelli M, et al. Changes in CD8+57+ T lymphocyte expansions after autologous hematopoietic stem cell transplantation correlate with changes in torquetenovirus viremia. Transplantation. 2008;85:1867-1868.
7. Sajeva MR, Greco MM, Cascavilla N, et al. Effective autologous peripheral blood stem cell transplantation in plasma cell leukemia followed by T-large granular lymphocyte expansion: A case report. Bone Marrow Transplant. 1996;18:225-227.
8. Lau LG, Tan LK, Salto-Tellez M, et al. T-cell post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: Another case and a review of the literature. Bone Marrow Transplant. 2004;34:821-822.
9. Dispenzieri A, Kyle R, Merlini G, et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia. 2009;23:215-224.
10. Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 2009;23:3-9.
11. Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood. 1993;82:1-14.
12. Ohgami RS, Ohgami JK, Pereira IT, et al. Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies. Leukemia. 2011;25:1439-1443.
13. Loughran TP. Large granular lymphocytic leukemia: An overview. Hosp Pract (Minneap). 1998;33:133-138.
14. Rossi D, Franceschetti S, Capello D, et al. Transient monoclonal expansion of CD8+/CD57+ T-cell large granular lymphocytes after primary cytomegalovirus infection. Am J Hematol. 2007;82:1103-1105.
15. Sabnani I, Tsang P. Are clonal T-cell large granular lymphocytes to blame for unexplained haematological abnormalities? Br J Haematol. 2007;136:30-37.
16. Isobe T, Tanimoto TE, Nakaji G, et al. Autoimmune thrombocytopenia with clonal expansion of CD8-positive T-cells after autologous peripheral blood stem cell transplantation for diffuse large B-cell lymphoma. Bone Marrow Transplant. 2005;35:315-316.
17. Sze DM, Giesajtis G, Brown RD, et al. Clonal cytotoxic T-cells are expanded in myeloma and reside in the CD8(+) CD57(+)CD28(-) compartment. Blood. 2001;98:2817-2827.
18. Halapi E, Werner A, Wahlstrom J, et al. T-cell repertoire in patients with multiple myeloma and monoclonal gammopathy of undetermined significance: Clonal CD8+ T-cell expansions are found preferentially in patients with a low tumor burden. Eur J Immunol. 1997;27:2245-2252.
19. Brown RD, Yuen E, Nelson M, et al. The prognostic significance of T-cell receptor beta gene rearrangements and idiotype-reactive T-cells in multiple myeloma. Leukemia. 1997;11:1312-1317.
20. Osterborg A, Werner A, Halapi E, et al. Clonal CD8+ and CD52-T-cells are induced in responding B cell lymphoma patients treated with Campath-1H (anti-CD52). Eur J Haematol. 1997;58:5-13.
21. Kollgaard T, Petersen SL, Hadrup SR, et al. Evidence for involvement of clonally expanded CD8+ T-cells in anticancer immune responses in CLL patients following nonmyeloablative conditioning and hematopoietic cell transplantation. Leukemia. 2005;19:2273-2280.