The Hypertension in the Very Elderly Trial - latest data

British Journal of Clinical Pharmacology

Volumn 75, Issue 4, 2013, Pages 951-954

  Mukhtar, Omar ^a   Jackson, Stephen H D ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Elderly; Hypertension; HYVET; Older adults; Treatment

Indexed keywords

ALCOHOL; INDAPAMIDE; PERINDOPRIL; PLACEBO;

ALCOHOL CONSUMPTION; ANTIHYPERTENSIVE THERAPY; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DIASTOLIC HYPERTENSION; DRINKING BEHAVIOR; DRUG TOLERABILITY; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; HYPERTENSION IN THE VERY ELDERLY TRIAL; MINI MENTAL STATE EXAMINATION; ORTHOSTATIC HYPOTENSION; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIDE EFFECT; SMOKING; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; URIC ACID BLOOD LEVEL;

AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; COGNITION DISORDERS; DELAYED-ACTION PREPARATIONS; DEMENTIA; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FRACTURES, BONE; HUMANS; HYPERTENSION; INDAPAMIDE; MULTICENTER STUDIES AS TOPIC; PERINDOPRIL; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84875064586     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04427.x     Document Type: Article

References (25)

1. Leishman AW. Hypertension - treated and untreated. BMJ 1961; 1: 1-5.
2. Hamilton M, Thompson EN, Wisniewski TKM. The role of blood pressure control in preventing complications of hypertension. Lancet 1964; 1: 235-238.
3. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129mm Hg. JAMA 1967; 202: 1028-1034.
4. Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the hypertension Detection and Follow-up Program: I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 1979; 242: 2562-2571.
5. Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the Hypertension Detection and Follow-up Program: II. Mortality by race-sex and age. JAMA 1979; 242: 2572-2577.
6. Amery A, Brixko P, Clement D, De Schaepdryver A, Fagard R, Forte J, Henry JF, Leonetti G, O'Malley K, Strasser T, Birkenhäger W, Bulpitt C, Deruyttere M, Dollery C, Forette F, Hamdy R, Joossens JV, Lund-Johansen P, Petrie J, Tuomilehto J, Williams B. Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly Trial. Lancet 1985; 1: 1349-1354.
7. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255-3264.
8. MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 1992; 304: 405-412.
9. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997; 350: 757-764.
10. Amery A, Birkenhäger W, Brixko P, Bulpitt C, Clement D, de Leeuw P, de Plaen JF, Deruyttere M, De Schaepdryver A, Dollery C, Fagard R, Feltkamp H, Forette F, Forte J, Hamdy R, Henry JF, Koistinen A, Leonetti G, Lund-Johansen P, Morris J, Nissinen A, O'Brien E, O'Malley K, Terzoli L, Tuomilehto J, Webster J, Williams B. Influence of antihypertensive drug treatment on morbidity and mortality in patients over the age of 60 years. European Working Party on High Blood Pressure in the Elderly (EWPHE) results: sub-group analysis on entry stratification. J Hypertens Suppl 1986; 4: S642-S647.
11. Gueyffier F, Bulpitt C, Boissel JP, Schron E, Ekbom T, Fagard R, Casiglia E, Kerlikowske K, Coope J. Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 1999; 353: 793-796.
12. Hypertension in the Very Elderly Trial Working Group. Results of the pilot study for the hypertension in the very elderly trial. J Hypertens 2003; 21: 2409-2417.
13. HYVET Study Group. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008; 358: 1887-1898.
14. Douma S, Petidis K, Zamboulis C. Treatment of hypertension in the elderly. N Engl J Med 2008; 359: 971-972.
15. Bulpitt CJ, Beckett NS, Peters R, Leonetti G, Gergova V, Fagard R, Burch LA, Banya W, Fletcher AE. Blood pressure control in the hypertension in the very elderly trial (HYVET). J Hum Hypertens 2012; 26: 157-163.
16. Messerli FH, Sulicka J, Gryglewska B. Treatment of hypertension in the elderly. N Engl J Med 2008; 359: 972-973.
17. Bulpitt CJ, Beckett NS, Peters R, Banya W, Liu L, Wang JG, Stoyanovsky V, Dumitrascu D, Nikitin Y, Staessen JA, Burch L, Fletcher AE. Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET). Blood Press 2009; 18: 17-22.
18. Mancia G, Grassi G. Treating very elderly hypertensive patients is rewarding: the HYVET results. Curr Hypertens Rep 2008; 10: 301-302.
19. Mukhtar O, Jackson SHD. Risk: benefit of treating high blood pressure in older adults. Br J Clin Pharmacol (in press). doi: 10.1111/j.1365-2125.2012.04375.x.
20. Beckett N, Peters R, Tuomilehto J, Swift C, Sever P, Potter J, McCormack T, Forette F, Gil-Extremera B, Dumitrascu D, Staessen JA, Thijs L, Fletcher A, Bulpitt C, HYVET Study Group. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to hypertension in the very elderly randomised controlled trial. BMJ 2012; 344: d7541.
21. Peters R, Beckett N, Burch L, de Vernejoul MC, Liu L, Duggan J, Swift C, Gil-Extremera B, Fletcher A, Bulpitt C. The effect of treatment based on a diuretic (indapamide) +/- ACE inhibitor (perindopril) on fractures in the hypertension in the very elderly trial (HYVET). Age Ageing 2010; 39: 609-616.
22. Peters R, Pinto E, Beckett N, Swift C, Potter J, McCormack T, Nunes M, Grimley-Evans J, Fletcher A, Bulpitt C. Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the hypertension in the very elderly trial (HYVET). Age Ageing 2010; 39: 439-445.
23. Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, Waldman A, Walton I, Poulter R, Ma S, Comsa M, Burch L, Fletcher A, Bulpitt C, HYVET Investigators. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008; 7: 683-689.
24. Peters R, Beckett N, Geneva M, Tzekova M, Lu FH, Poulter R, Gainsborough N, Williams B, de Vernejoul MC, Fletcher A, Bulpitt C. Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age Ageing 2009; 38: 521-527.
25. Peters R, Beckett N, Beardmore R, Peña-Miller R, Rockwood K, Mitnitski A, Mt-Isa S, Bulpitt C. Modelling cognitive decline in the Hypertension in the Very Elderly Trial [HYVET] and proposed risk tables for population use. PLoS ONE 2010; 5: e11775.