Temporal and Pharmacological Characterization of Angiostatin Release and Generation by Human Platelets: Implications for Endothelial Cell Migration

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Radziwon Balicka, Aneta ^a   Moncada de la Rosa, Cesar ^a   Zielnik, Barbara ^a   Doroszko, Adrian ^b   Jurasz, Paul ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOSTATIN; APROTININ; GLYCOPROTEIN; PROSTACYCLIN; PROTEIN GPIIB; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; BLOOD CLOTTING; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGOLD ELECTRON MICROSCOPY; INHIBITION KINETICS; NEOVASCULARIZATION (PATHOLOGY); PROTEIN SECRETION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ADENINE; ANGIOGENESIS INHIBITORS; ANGIOSTATINS; ASPIRIN; BLOOD PLATELETS; CELL HYPOXIA; CELL LINE; CELL MOVEMENT; COLLAGEN; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; HUMANS; PEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; S-NITROSOGLUTATHIONE; VALERATES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84875021120     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059281     Document Type: Article

References (33)

1. Browder T, Folkman J, Pirie-Shepherd S, (2000) The Hemostatic System as a Regulator of Angiogenesis. J Biol Chem 275: 1521-1524.
2. Radziwon-Balicka A, Moncada de la Rosa C, Jurasz P, (2012) Platelet-associated angiogenesis regulating factors: a pharmacological perspective. Can J Physiol Pharmacol 90: 679-688.
3. Jurasz P, Yurkova N, Kirshenbaum LA, Stewart DJ, (2011) VEGF Masks BNIP3-mediated Apoptosis of Hypoxic Endothelial Cells. Angiogenesis 14: 199-207.
4. Mohle R, Green D, Moore M, Nachman R, Rafii S, (1997) Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci USA 94: 663-668.
5. Jurasz P, Alonso D, Castro-Blanco S, Murad F, Radomski MW, (2003) Generation and role of angiostatin in human platelets. Blood 102: 3217-3223.
6. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328.
7. Falcone DJ, Khan KMF, Layne T, Fernandes L, (1998) Macrophage Formation of Angiostatin during Inflammation. J Biol Chem 273: 31480-31485.
8. Jurasz P, Ng D, Granton JT, Courtman DW, Stewart DJ, (2010) Elevated platelet angiostatin and circulating endothelial microfragments in idiopathic pulmonary arterial hypertension: A preliminary study. Thromb Res 125: 53-60.
9. Jurasz P, Santos-Martinez MJ, Radomska A, Radomski MW, (2006) Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects on angiogenesis. J Thromb Haemost 4: 1095-1106.
10. Griscelli F, Li H, Bennaceur-Griscelli A, Soria J, Opolon P, et al. (1998) Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc Natl Acad Sci USA 95: 6367-6372.
11. Meena RS, George PT, Mahesh CS, (2004) Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem 91: 398-409.
12. Gately S, Twardowski P, Stack MS, Patrick M, Boggio L, et al. (1996) Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor angiostatin. Cancer Res 56: 4887-4890.
13. Ji W-r, Castellino FJ, Chang Y, Deford ME, Gray H, et al. (1998) Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis. FASEB J 12: 1731-1738.
14. Troyanovsky B, Levchenko T, Mansson G, Matvijenko O, Holmgren L, (2001) Angiomotin: An angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol 152: 1247-1254.
15. Claesson-Welsh L, Welsh M, Ito N, Anand-Apte B, Soker S, et al. (1998) Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc Natl Acad Sci USA 95: 5579-5583.
16. Hanford HA, Wong CA, Kassan H, Cundiff DL, Chandel N, et al. (2003) Angiostatin4.5-mediated apoptosis of vascular endothelial cells. Cancer Res 63: 4275-4280.
17. Veitonmaki N, Cao R, Wu L-H, Moser TL, Li B, et al. (2004) Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-induced antiangiogenesis. Cancer Res 64: 3679-3686.
18. Radziwon-Balicka A, Ramer C, Moncada de la Rosa C, Zielnik-Drabik B, Jurasz P (2012) Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: a hypoxia specific mechanism of action. Vasc Pharmacol In press.
19. Radomski A, Jurasz P, Sanders EJ, Overall CM, Bigg HF, et al. (2002) Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. Br J Pharmacol 137: 1330-1338.
20. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, et al. (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha-granules and differentially released. Blood 111: 1227-1233.
21. Kamykowski J, Carlton P, Sehgal S, Storrie B, (2011) Quantitative immunofluorescence mapping reveals little functional co-clustering of proteins within platelet alpha-granules. Blood 118: 1370-1373.
22. Ma L, Perini R, McKnight W, Dicay M, Klein A, et al. (2005) Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 102: 216-220.
23. Radomski MW, Palmer R, Moncada S, (1987a) Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 92: 181-187.
24. Zhang C, Yang Y (2012) Microparticles are the basic storage units for different proteins in platelet granules. Blood Jul 24. In press.
25. Folkman J (2008) Angiostatin and Endostatin: Angiogenesis inhibitors in blood and stroma. [In] Angiogenesis: an integretive approach from science to medicine. 133 p.
26. Radomski MW, Palmer RMJ, Moncada S, (1987b) Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. The Lancet 330: 1057-1058.
27. Hagberg A, Solvik UO, Updahl H, Roald HD, Lyberg T, (1999) Inhalation of nitric oxide inhibits ADP-induced platelet aggregation and alpha-granule release. Platelets 10: 382-390.
28. Menter DG, OJ, Moilanen D, Sloane BF, Taylor JD, Honn KV, (1987) Inhibition by prostacyclin of the tumor cell-induced platelet release reaction and platelet aggregation. J Natl Cancer Inst. 78: 961-969.
29. Battinelli EM, Markens BA, Italiano JE, (2011) Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood 118: 1359-1369.
30. Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, et al. (2001) Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci USA 98: 6470-6475.
31. Amirkhosravi A, Amaya M, Siddiqui F, Biggerstaff JP, Meyer TV, et al. (1999) Blockade of GpIIb/IIIa inhibits the release of vascular endothelial growth factor (VEGF) from tumor cell-activated platelets and experimental metastasis. Platelets 10: 285-292.
32. Fergusson DA, Hebert PC, Mazer CD, Fremes S, MacAdams C, et al. (2008) A Comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery. Engl J Med 358: 2319-2331.
33. Howell N, Senanayake E, Freemantle N, Pagano D (2012) Putting the record straight on aprotinin as safe and effective: Results from a mixed treatment meta-analysis of trials of aprotinin. J Thorac Cardiovasc Surg Aug 10. In press.