Addition of time-dependent covariates to a survival model significantly improved predictions for daily risk of hospital death

Journal of Evaluation in Clinical Practice

Volumn 19, Issue 2, 2013, Pages 351-357

  Wong, Jenna ^a,b   Taljaard, Monica ^a   Forster, Alan J ^a,b,c   Escobar, Gabriel J ^d   Van Walraven, Carl ^a,b,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d DIVISION OF RESEARCH   (United States)

Author keywords

in hospital mortality; model calibration; model discrimination; risk prediction; survival analysis; time dependent covariates

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL PRACTICE; COHORT ANALYSIS; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; ELIXHAUSER COMORBIDITY INDEX; ESCOBAR MODEL; FEMALE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RECEIVER OPERATING CHARACTERISTIC; RISK ASSESSMENT; SURVIVAL TIME;

AGED; FEMALE; HOSPITAL MORTALITY; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; MODELS, THEORETICAL; ONTARIO; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 84874976391     PISSN: 13561294     EISSN: 13652753     Source Type: Journal    
DOI: 10.1111/j.1365-2753.2012.01832.x     Document Type: Article

References (13)

1. Shahian, D. M., Wolf, R. E., Iezzoni, L. I., Kirle, L., &, Normand, S. L., (2010) Variability in the measurement of hospital-wide mortality rates. New England Journal of Medicine, 363 (26), 2530-2539.
2. Wong, J., Taljaard, M., Forster, A. J., Escobar, G. J., &, van Walraven, C., (2011) Derivation and validation of a model to predict daily risk of death in hospital. Medical Care, 49 (8), 734-743.
3. Escobar, G. J., Greene, J. D., Scheirer, P., Gardner, M. N., Draper, D., &, Kipnis, P., (2008) Risk-adjusting hospital inpatient mortality using automated inpatient, outpatient, and laboratory databases. Medical Care, 46 (3), 232-239.
4. van Walraven, C., Austin, P. C., Jennings, A., Quan, H., &, Forster, A. J., (2009) A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Medical Care, 47 (6), 626-633.
5. van Walraven, C., Escobar, G. J., Greene, J. D., &, Forster, A. J., (2010) The Kaiser Permanente inpatient risk adjustment methodology was valid in an external patient population. Journal of Clinical Epidemiology, 63 (7), 798-803.
6. van Walraven, C., Wong, J., Bennett, C., &, Forster, A. J., (2011) The Procedural Index for Mortality Risk (PIMR): an index calculated using administrative data to quantify the independent influence of procedures on risk of hospital death. BMC Health Services Research, 11, 258.
7. Wei, L. J., Lin, D. Y., &, Weissfeld, L., (1989) Regression analysis of multivariate incomplete failure time data by modeling marginal distributions. Journal of the American Statistical Association, 84 (408), 1065-1073.
8. Kremers, W. K., (2007) Concordance for Survival Time Data: Fixed and Time-Dependent Covariates and Possible Ties in Predictor and Time. Rochester, MN: Mayo Foundation.
9. May, S., &, Hosmer, D. W., (1998) A simplified method of calculating an overall goodness-of-fit test for the Cox proportional hazards model. Lifetime Data Analysis, 4 (2), 109-120.
10. Pencina, M. J., D'Agostino, R. B. Sr, D'Agostino, R. B. Jr, &, Vasan, R. S., (2008) Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Statistics in Medicine, 27 (2), 157-172.
11. Pencina, M. J., D'Agostino, R. B. Sr, &, Steyerberg, E. W., (2011) Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Statistics in Medicine, 30 (1), 11-21.
12. Litvak, E., &, Pronovost, P. J., (2010) Rethinking rapid response teams. Journal of the American Medical Association, 304 (12), 1375-1376.
13. Escobar, G. J., Greene, J. D., Gardner, M. N., Marelich, G. P., Quick, B., &, Kipnis, P., (2011) Intra-hospital transfers to a higher level of care: contribution to total hospital and intensive care unit (ICU) mortality and length of stay (LOS). Journal of Hospital Medicine, 6 (2), 74-80.