A large animal neuropathic pain model in sheep: A strategy for improving the predictability of preclinical models for therapeutic development

Journal of Pain Research

Volumn 5, Issue , 2012, Pages 415-424

  Wilkes, Denise ^a   Li, Guangwen ^a   Angeles, Carmina F ^a   Patterson, Joel T ^b   Huang, Li Yen Mae ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Neurospine Institute   (United States)

Author keywords

Interspecies drug scaling; Neuropathic pain model; Ovine; Ovine pain model

Indexed keywords

MORPHINE;

ALLOMETRY; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CEREBROSPINAL FLUID; CHRONIC PAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; EVOKED RESPONSE; FEMALE; NEUROANATOMY; NEUROPATHIC PAIN; NONHUMAN; PERCEPTIVE THRESHOLD; PREDICTION; SHEEP; SPECIES COMPARISON;

EID: 84874976029     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S34977     Document Type: Article

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