Extended pain relief trial utilizing infiltration of Exparel®, a long-acting multivesicular liposome formulation of bupivacaine: A Phase IV health economic trial in adult patients undergoing open colectomy

Journal of Pain Research

Volumn 5, Issue , 2012, Pages 567-572

  Cohen, Stephen M ^a  

^a Atlanta Colon and Rectal Surgery Department   (United States)

Author keywords

Cost; Length of stay; Multimodal analgesia; Opioid consumption; Surgery

Indexed keywords

BUPIVACAINE; CREATININE; HYDROMORPHONE; IBUPROFEN; KETOROLAC; MORPHINE; PARACETAMOL;

ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; ASTHENIA; BRADYCARDIA; CLINICAL ARTICLE; COLON RESECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; DRUG USE; FATIGUE; FEMALE; HEMATOMA; HOSPITAL COST; HOSPITALIZATION; HUMAN; HYPERTENSION; ILEUS; LENGTH OF STAY; MALE; OUTCOME ASSESSMENT; PHASE 4 CLINICAL TRIAL; PLEURA EFFUSION; POSTOPERATIVE PAIN; SMALL INTESTINE OBSTRUCTION; UNSPECIFIED SIDE EFFECT;

EID: 84874966264     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S38621     Document Type: Article

References (15)

1. Clinicians' quick reference guide to postoperative pain management in adults. Pain Management Guideline Panel. Agency for Health Care Policy and Research, US Department of Health and Human Services. J Pain Symptom Manage. 1992;7:214-228.
2. The Joint Commission. Facts about pain management. Available from: http://www.jointcommission.org/pain_management/. Accessed August 21, 2012.
3. Rowlingson JC, Rawal N. Postoperative pain guidelines-targeted to the site of surgery. Reg Anesth Pain Med. 2003;28:265-267.
4. Apfelbaum JL. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology. 2012;116:248-273.
5. Warfield CA, Kahn CH. Acute pain management. Programs in US hospitals and experiences and attitudes among US adults. 1995;83:1090-1094.
6. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97:534-540.
7. Sommer M, de Rijke JM, Van Kleef M, et al. The prevalence of postoperative pain in a sample of 1490 surgical inpatients. Eur J Anaesthesiol. 2008;25:267-274.
8. Gramke HF, de Rijke JM, Van Kleef M, et al. The prevalence of postoperative pain in a cross-sectional group of patients after day-case surgery in a university hospital. Clin J Pain. 2007;23:543-548.
9. Beauregard L, Pomp A, Choiniere M. Severity and impact of pain after day-surgery. Can J Anaesth. 1998;45:304-311.
10. White PF. Multimodal analgesia: its role in preventing postoperative pain. Curr Opin Investig Drugs. 2008;9:76-82.
11. Oderda GM, Said Q, Evans RS, et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother. 2007;41:400-406.
12. Adamson RT, Lew I, Beyzarov E, Amara S, Reitan J. Clinical and economic implications of postsurgical use of opioid therapy. Hosp Pharm. 2011;46(6 Suppl 1):S4-S11.
13. Exparel (bupivacaine liposome injectable suspension) [package insert]. San Diego, CA: Pacira Pharmaceuticals Inc; 2011.
14. International Conference on Harmonisation Working Group. ICH Harmonised Tripartite Guideline: Guideline for Good Clinical Practice E6 (R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; June 10, 1996; Washington, DC. Available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6_R1/Step4/E6_R1__Guideline.pdf. Accessed April 19, 2012.
15. Polglase AL, McMurrick PJ, Simpson PJ, et al. Continuous wound infusion of local anesthetic for the control of pain after elective abdominal colorectal surgery. Dis Colon Rectum. 2007;50:2158-2167.