Lipidoid-coated iron oxide nanoparticles for efficient DNA and siRNA delivery

Nano Letters

Volumn 13, Issue 3, 2013, Pages 1059-1064

  Jiang, Shan ^a,b   Eltoukhy, Ahmed A ^a   Love, Kevin T ^a,b   Langer, Robert ^a,b   Anderson, Daniel G ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

DNA delivery; gene therapy; iron oxide nanoparticle; magnetofection; siRNA delivery

Indexed keywords

COATED NANOPARTICLES; DNA DELIVERY; EXTERNAL MAGNETIC FIELD; IRON OXIDE NANOPARTICLE; MAGNETIC HYPERTHERMIA; MAGNETOFECTION; NUCLEIC ACID DELIVERIES; SIRNA DELIVERY;

DRUG THERAPY; GENE THERAPY; LIPOSOMES; OPTIMIZATION; RNA;

METAL NANOPARTICLES;

DNA; FERRIC ION; FERRIC OXIDE; LIPID; METAL NANOPARTICLE; SMALL INTERFERING RNA;

ARTICLE; CHEMISTRY; TRANSMISSION ELECTRON MICROSCOPY;

DNA; FERRIC COMPOUNDS; LIPIDS; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; RNA, SMALL INTERFERING;

EID: 84874961058     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl304287a     Document Type: Article

References (28)

1. Verma, I. M.; Somia, N. Gene therapy-promises, problems and prospects Nature 1997, 389 (6648) 239-242
2. Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking down barriers: advances in siRNA delivery Nat. Rev. Drug Discov. 2009, 8 (2) 129-138
3. Anderson, D. G.; Lynn, D. M.; Langer, R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery Angew. Chem., Int. Ed. 2003, 42 (27) 3153-3158
4. Schlachter, E. K.; Widmer, H. R.; Bregy, A.; Lonnfors-Weitzel, T.; Vajtai, I.; Corazza, N.; Bernau, V. J. P.; Weitzel, T.; Mordasini, P.; Slotboom, J.; Herrmann, G.; Bogni, S.; Hofmann, H.; Frenz, M.; Reinert, M. Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study Int. J. Nanomed. 2011, 6, 1793-1800
5. Tassa, C.; Shaw, S. Y.; Weissleder, R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy Acc. Chem. Res. 2011, 44 (10) 842-852
6. Driscoll, C. F.; Morris, R. M.; Senyei, A. E.; Widder, K. J.; Heller, G. S. Magnetic Targeting of Microspheres in Blood-Flow Microvasc. Res. 1984, 27 (3) 353-369
7. Hergt, R.; Dutz, S.; Muller, R.; Zeisberger, M. Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy J. Phys.: Condes. Matter 2006, 18 (38) S2919-S2934
8. Gupta, A. K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications Biomaterials 2005, 26 (18) 3995-4021
9. Park, J.; An, K. J.; Hwang, Y. S.; Park, J. G.; Noh, H. J.; Kim, J. Y.; Park, J. H.; Hwang, N. M.; Hyeon, T. Ultra-large-scale syntheses of monodisperse nanocrystals Nat. Mater. 2004, 3 (12) 891-895
10. Kim, J.; Kim, H. S.; Lee, N.; Kim, T.; Kim, H.; Yu, T.; Song, I. C.; Moon, W. K.; Hyeon, T. Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery Angew. Chem., Int. Ed. 2008, 47 (44) 8438-8441
11. Amstad, E.; Gillich, T.; Bilecka, I.; Textor, M.; Reimhult, E. Ultrastable Iron Oxide Nanoparticle Colloidal Suspensions Using Dispersants with Catechol-Derived Anchor Groups Nano Lett. 2009, 9 (12) 4042-4048
12. El Khoury, J. M.; Caruntu, D.; O' Connor, C. J.; Jeong, K. U.; Cheng, S. Z. D.; Hu, J. Poly(allylamine) stabilized iron oxide magnetic nanoparticles J. Nanopart. Res. 2007, 9 (5) 959-964
13. Liao, M. H.; Chen, D. H. Preparation and characterization of a novel magnetic nano-adsorbent J. Mater. Chem. 2002, 12 (12) 3654-3659
14. Ditsch, A.; Laibinis, P. E.; Wang, D. I. C.; Hatton, T. A. Controlled clustering and enhanced stability of polymer-coated magnetic nanoparticles Langmuir 2005, 21 (13) 6006-6018
15. Yoon, K. Y.; Kotsmar, C.; Ingram, D. R.; Huh, C.; Bryant, S. L.; Milner, T. E.; Johnston, K. P. Stabilization of Superparamagnetic Iron Oxide Nanoclusters in Concentrated Brine with Cross-Linked Polymer Shells Langmuir 2011, 27 (17) 10962-10969
16. Meyer, E. E.; Lin, Q.; Hassenkam, T.; Oroudjev, E.; Israelachvili, J. N. Origin of the long-range attraction between surfactant-coated surfaces Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (19) 6839-6842
17. Gonzales, M.; Krishnan, K. M. Synthesis of magnetoliposomes with monodisperse iron oxide nanocrystal cores for hyperthermia J. Magn. Magn. Mater. 2005, 293 (1) 265-270
18. Namiki, Y.; Namiki, T.; Yoshida, H.; Ishii, Y.; Tsubota, A.; Koido, S.; Nariai, K.; Mitsunaga, M.; Yanagisawa, S.; Kashiwagi, H.; Mabashi, Y.; Yumoto, Y.; Hoshina, S.; Fujise, K.; Tada, N. A novel magnetic crystal-lipid nanostructure for magnetically guided in vivo gene delivery Nature Nanotechnol. 2009, 4 (9) 598-606
19. Israelachvili, J. N., Intermolecular and Surface Forces. 3 ed.; Academic Press: Waltham, MA, 2010.
20. Greco, F. A. Polar, Aprotic-Solvents and the Hydrophobic Effect J. Phys. Chem. 1984, 88 (14) 3132-3133
21. Tong, S.; Hou, S. J.; Ren, B. B.; Zheng, Z. L.; Bao, G. Self-Assembly of Phospholipid-PEG Coating on Nanoparticles through Dual Solvent Exchange Nano Lett. 2011, 11 (9) 3720-3726
22. Love, K. T.; Mahon, K. P.; Levins, C. G.; Whitehead, K. A.; Querbes, W.; Dorkin, J. R.; Qin, J.; Cantley, W.; Qin, L. L.; Racie, T.; Frank-Kamenetsky, M.; Yip, K. N.; Alvarez, R.; Sah, D. W. Y.; de Fougerolles, A.; Fitzgerald, K.; Koteliansky, V.; Akinc, A.; Langer, R.; Anderson, D. G. Lipid-like materials for low-dose, in vivo gene silencing Proc. Natl. Acad. Sci. U.S.A. 2010, 107 (5) 1864-1869
23. Peters, J. P.; Maher, L. J. DNA curvature and flexibility in vitro and in vivo Q. Rev. Biophys. 2010, 43 (1) 23-63
24. Garcia, H. G.; Grayson, P.; Han, L.; Inamdar, M.; Kondev, J.; Nelson, P. C.; Phillips, R.; Widom, J.; Wiggins, P. A. Biological consequences of tightly bent DNA: The other life of a macromolecular celebrity Biopolymers 2007, 85 (2) 115-130
25. Boal, D., Mechanics of the Cell, 2 nd ed.; Cambridge University Press: Cambridge, U.K., 2012; p 624.
26. Luo, D.; Saltzman, W. M. Enhancement of transfection by physical concentration of DNA at the cell surface Nat. Biotechnol. 2000, 18 (8) 893-895
27. Maeda, H., The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting. In Advances in Enzyme Regulation; Weber, G., Ed.; Pergamon-Elsevier Science Ltd: Oxford, U.K., 2001; Vol. 41, pp 189-207.
28. Singh, N.; Agrawal, A.; Leung, A. K. L.; Sharp, P. A.; Bhatia, S. N. Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference J. Am. Chem. Soc. 2010, 132 (24) 8241-8243