Diffuse alveolar hemorrhage and libman-sacks endocarditis as a manifestation of possible primary antiphospholipid syndrome

Journal of Clinical Rheumatology

Volumn 19, Issue 2, 2013, Pages 79-83

  Koolaee, Roodabeh Michelle ^a   Moran, Anna M ^b   Shahane, Anupama ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

anticardiolipin antibodies; antiphospholipid syndrome; diffuse alveolar hemorrhage; lupus anticoagulant; pulmonary capillaritis; pulmonary hemorrhage

Indexed keywords

ANTINUCLEAR ANTIBODY; AZATHIOPRINE; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; HEMOGLOBIN; IMMUNOGLOBULIN G; LUPUS ANTICOAGULANT; METHYLPREDNISOLONE; PREDNISONE; WARFARIN;

ADULT; ANTIBODY BLOOD LEVEL; ANTICOAGULANT THERAPY; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BRONCHOSCOPY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; ENDOCARDITIS; FOLLOW UP; HEART VALVE REPLACEMENT; HEMOGLOBIN BLOOD LEVEL; HEMOPTYSIS; HISTIOCYTE; HUMAN; HUMAN TISSUE; INTERNATIONAL NORMALIZED RATIO; LIBMAN SACKS ENDOCARDITIS; LUNG BIOPSY; LUNG HEMORRHAGE; LYMPH NODE DISSECTION; MACROPHAGE; MALE; MEAN CORPUSCULAR VOLUME; MITRAL VALVE REGURGITATION; MITRAL VALVE REPLACEMENT; PARTIAL THROMBOPLASTIN TIME; PLASMAPHERESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SYSTOLIC HEART MURMUR; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSTHORACIC ECHOCARDIOGRAPHY; VIDEO ASSISTED THORACOSCOPIC SURGERY;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ECHOCARDIOGRAPHY; ENDOCARDITIS, NON-INFECTIVE; HEART VALVE PROSTHESIS IMPLANTATION; HEMOPTYSIS; HEMORRHAGE; HUMANS; LUNG DISEASES; MALE; MITRAL VALVE; MITRAL VALVE INSUFFICIENCY; PULMONARY ALVEOLI; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84874948263     PISSN: 10761608     EISSN: 15367355     Source Type: Journal    
DOI: 10.1097/RHU.0b013e318278c577     Document Type: Article

References (21)

1. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295-306
2. Erkan D, Lockshin MD. Non-criteria manifestations of antiphopholipid syndrome. Lupus. 2010;19:424-427
3. Scheiman Elazary A, Cohen MJ, Aamar S, et al. Pulmonary hemorrhage in antiphospholipid antibody syndrome. J Rheumatol. 2012;39:1628-1631
4. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthritis Rheum. 2002;46:1019-1027
5. Cervera R, Tektonidou MG, Espinosa G, et al. Task force on catastrophic antiphospholipid syndrome (APS) and non-criteria APS manifestations: Catastrophic APS, APS nephropathy and heart valve lesions. Lupus. 2011;20:165-173
6. Hillerdal G, Hagg A, Licke G, et al. Case report: Intra-alveolar haemorrhage in the anticardiolipin antibody syndrome. Scand J Rheumatol. 1991;20:58-62
7. Gertner E, Lie JT. Care report: Pulmonary capillaritis, alveolar hemorrhage, and recurrent microvascular thrombosis in primary antiphospholipid syndrome. J Rheumatol. 1993;20:1224-1228
8. Crausman R, Achenbach G, Pluss W, et al. Case report: Pulmonary capillaritis and alveolar hemorrhage associated with the antiphospholipid antibody syndrome. J Rheumatol. 1995;22:554-556
9. Gertner E. Diffuse alveolar hemorrhage in the antiphospholipid syndrome: Spectrum of disease and treatment. J Rheumatol. 1999;26:805-807
10. Waterer GW, Latham B, Waring J, et al. Case report: Pulmonary capillaritis associated with the antiphospholipid syndrome and rapid response to plasmapheresis. Respirology. 1999;4:405-408
11. Asherson R, Greenblatt M. Recurrent alveolar hemorrhage and pulmonary capillaritis in the ''primary'' antiphospholipid syndrome. J Clin Rheumatol. 2001;7:30-33
12. Deane KD, West SG. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: A case series and literature review. Semin Arthritis Rheum. 2005;35:154-165
13. Suzuki A, Asazuma N, Kikuchi E, et al. ''Possible primary antiphospholipid syndrome'' with concurrent diffuse alveolar hemorrhaging and Libman-Sacks endocarditis mimicking catastrophic antiphospholipid syndrome. Intern Med. 2012;51:813-816
14. Scheiman Elazary A, Klahr PP, Hershko AY, et al. Rituximab induces resolution of recurrent diffuse alveolar hemorrhage in a patient with primary antiphospholipid antibody syndrome. Lupus. 2012;21:438-440
15. Lafosse-Marin M, Marcq M, Diot P, et al. Intra-alveolar pulmonary haemorrhage, an unusual manifestation of the primary antiphospholipid syndrome. Rev Med Interne. 2009;30:271-273
16. Marcos Rodríguez PJ, Montero Martínez C, Verea Hernando H. Pulmonary haemorrhage and primary antiphospholipid syndrome: Case report and review. An Med Interna. 2007;24:125-128
17. Asherson R, Cervera R, Wells AU. Editorial: Diffuse alveolar hemorrhage: A nonthrombotic antiphospholipid lung syndrome? Semin Arthritis Rheum. 2005;35:138-142
18. Holers VM, Girardi G, Mo L, et al. Complement C3 activation is required for antiphospholipid antibodyYinduced fetal loss. J Exp Med. 2002;195:211-220
19. Salmon JE, Girardi G, Holers VM. Activation of complement mediates antiphospholipid antibodyYinduced pregnancy loss. Lupus. 2003;12:535-538
20. Girardi G, Berman J, Redecha P, et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid antibody syndrome. J Clin Invest. 2003;112:1644-1654
21. Bucciarelli S, Espinosa G, Cervera R, et al. Mortality in catastrophic antiphospholipid syndrome: Causes of death and prognostic factors in a series of 250 patients. Arthritis Rheum. 2006;54:2568-2576