Multiple autoantibodies display association with lymphopenia, proteinuria, and cellular casts in a large, ethnically diverse SLE patient cohort

Autoimmune Diseases

Volumn 1, Issue 1, 2012, Pages

  Lu, Rufei ^a,b   Robertson, Julie M ^a   Bruner, Benjamin F ^a,c   Guthridge, Joel M ^a   Neas, Barbara R ^d   Nath, Swapan K ^a   Kelly, Jennifer A ^a   Moser Sivils, Kathy L ^a   Chakravarty, Eliza F ^a   Kamen, Diane L ^e   Gilkeson, Gary S ^e   Wallace, Daniel J ^f   Weisman, Michael H ^f   Scofield, R Hal ^a,b,g   Harley, John B ^h,i   James, Judith A ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c HARDING UNIVERSITY   (United States)

^d UNIVERSITY OF OKLAHOMA   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f CEDARS SINAI MEDICAL CENTER   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CHROMATIN ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; LA ANTIBODY; RIBONUCLEOPROTEIN ANTIBODY; RIBOSOMAL P ANTIBODY; RO ANTIBODY; SM ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; AMERICAN INDIAN; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTHRITIS; ARTICLE; ASIAN AMERICAN; CLINICAL FEATURE; COHORT ANALYSIS; ETHNIC DIFFERENCE; EUROPEAN AMERICAN; FEMALE; HEMOLYTIC ANEMIA; HISPANIC; HUMAN; LEUKOPENIA; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; PERICARDITIS; PHOTOSENSITIVITY; PLEURISY; PRIORITY JOURNAL; PROTEINURIA; PSYCHOSIS; RASH; SEIZURE; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; URINALYSIS; URINE CELLULAR CAST; ANTIBODY SCREENING; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONTROLLED STUDY; ETHNICITY;

EID: 84874907638     PISSN: None     EISSN: 20900430     Source Type: Journal    
DOI: 10.1155/2012/819634     Document Type: Article

References (47)

1. Sherer Y., Gorstein A., Fritzler M. J., Shoenfeld Y., Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Seminars in Arthritis and Rheumatism 2004 34 2 501 537 2-s2.0-14244250736 10.1016/j.semarthrit.2004.07.002 (Pubitemid 40288129)
2. Agmon-Levin N., Mosca M., Petri M., Shoenfeld Y., Systemic lupus erythematosus one disease or many? Autoimmunity Reviews 2012 11 8 593 595 2-s2.0-84858429634 10.1016/j.autrev.2011.10.020
3. Mahler M., Miyachi K., Peebles C., Fritzler M. J., The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA). Autoimmunity Reviews 2012 11 10 771 775 2-s2.0-84857948450 10.1016/j.autrev. 2012.02.012
4. Heinlen L. D., McClain M. T., Ritterhouse L. L., Bruner B. F., Edgerton C. C., Keith M. P., James J. A., Harley J. B., 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity. PLoS One 2010 5 3 e9599 2-s2.0-77949702395 10.1371/journal.pone.0009599
5. Heinlen L. D., McClain M. T., Merrill J., Akbarali Y. W., Edgerton C. C., Harley J. B., James J. A., Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis and Rheumatism 2007 56 7 2344 2351 2-s2.0-34547426477 10.1002/art.22665 (Pubitemid 47173582)
6. Arbuckle M. R., McClain M. T., Rubertone M. V., Hal Scofield R., Dennis G. J., James J. A., Harley J. B., Development of autoantibodies before the clinical onset of systemic lupus erythematosus. New England Journal of Medicine 2003 349 16 1526 1533 2-s2.0-0142009533 10.1056/NEJMoa021933 (Pubitemid 37255038)
7. Arbuckle M. R., James J. A., Dennis G. J., Rubertone M. V., McClain M. T., Kim X. R., Harley J. B., Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus. Lupus 2003 12 2 99 106 2-s2.0-0037286296 10.1191/0961203303lu334oa (Pubitemid 36240842)
8. Arbuckle M. R., James J. A., Kohlhase K. F., Rubertone M. V., Dennis G. J., Harley J. B., Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scandinavian Journal of Immunology 2001 54 1-2 211 219 2-s2.0-0034951841 10.1046/j.1365-3083.2001.00959.x (Pubitemid 32592348)
9. Heinlen L. D., Ritterhouse L. L., McClain M. T., Keith M. P., Neas B. R., Harley J. B., James J. A., Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides. Journal of Molecular Medicine 2010 88 7 719 727 2-s2.0-77954543289 10.1007/s00109-010-0618-1
10. Gilliam B. E., Ombrello A. K., Burlingame R. W., Pepmueller P. H., Moore T. L., Measurement of autoantibodies in pediatric-onset systemic lupus erythematosus and their relationship with disease-associated manifestations. Seminars in Arthritis and Rheumatism 2012 41 6 840 848 2-s2.0-84861222651 10.1016/j.semarthrit.2011.09.009
11. Harley J. B., Sestak A. L., Willis L. G., Fu S. M., Hansen J. A., Reichlin M., A model for disease heterogeneity in systemic lupus erythematosus. Relationships between histocompatibility antigens, autoantibodies, and lymphopenia or renal disease. Arthritis and Rheumatism 1989 32 7 826 836 2-s2.0-0024380543 (Pubitemid 19181004)
12. Hitchon C. A., Peschken C. A., Sm antibodies increase risk of death in systemic lupus erythematosus. Lupus 2007 16 3 186 194 2-s2.0-33947720479 10.1177/0961203306076220 (Pubitemid 46506596)
13. Vilá L. M., Alarcón G. S., McGwin G., Bastian H. M., Fessler B. J., Reveille J. D., Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual. Arthritis Care and Research 2006 55 5 799 806 2-s2.0-33750339734 10.1002/art.22224 (Pubitemid 44619195)
14. Ter Borg E. J., Horst G., Hummel E. J., Limburg P. C., Kallenberg C. G. M., Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study. Arthritis and Rheumatism 1990 33 5 634 643 2-s2.0-0025374697 10.1002/art.1780330505 (Pubitemid 20166564)
15. Reichlin M., Broyles T. F., Hubscher O., James J., Lehman T. A., Palermo R., Stafford H. A., Taylor-Albert E., Wolfson-Reichlin M., Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease. Arthritis and Rheumatism 1999 42 1 69 75 2-s2.0-0032922275 10.1002/1529-0131(199901)42:169::AID-ANR9>3.0.CO;2- J (Pubitemid 29042572)
16. Malik S., Bruner G. R., Williams-Weese C., Feo L., Hal Scofield R., Reichlin M., Harley J. B., Sawalha A. H., Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients. Lupus 2007 16 11 863 866 2-s2.0-36349032254 10.1177/0961203307083365 (Pubitemid 350157271)
17. Pradhan V. D., Badakere S. S., Bichile L. S., Dolas M. P., Antibodies to Ro/SS-A and La/SS-B in systemic lupus erythematosus and other autoimmune disorders. Journal of Association of Physicians of India 2002 50 6 762 765 2-s2.0-0036594638
18. Grader-Beck T., Wigley F. M., Raynaud's phenomenon in mixed connective tissue disease. Rheumatic Disease Clinics of North America 2005 31 3 465 481 2-s2.0-23444442524 10.1016/j.rdc.2005.04.006 (Pubitemid 41111549)
19. McCarty G. A., Harley J. B., Reichlin M., A distinctive autoantibody profile in black female patients with lupus nephritis. Arthritis and Rheumatism 1993 36 11 1560 1565 2-s2.0-0027444625 10.1002/art.1780361110 (Pubitemid 23327754)
20. Tseng C. E., Buyon J. P., Kim M., Belmont H. M., Mackay M., Diamond B., Marder G., Rosenthal P., Haines K., Ilie V., Abramson S. B., The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial. Arthritis and Rheumatism 2006 54 11 3623 3632 2-s2.0-33750936797 10.1002/art.22198 (Pubitemid 44737174)
21. McClain M. T., Arbuckle M. R., Heinlen L. D., Dennis G. J., Roebuck J., Rubertone M. V., Harley J. B., James J. A., The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis and Rheumatism 2004 50 4 1226 1232 2-s2.0-1842783797 10.1002/art.20120 (Pubitemid 38480833)
22. Tan E. M., Cohen A. S., Fries J. F., The 1982 revised criteria for the classification of systemic lupus erythrematosus. Arthritis and Rheumatism 1982 25 11 1271 1277 2-s2.0-0020436689 (Pubitemid 13221242)
23. Hochberg M. C., Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis and Rheumatism 1997 40 9 1725 2-s2.0-0031229830
24. Rasmussen A., Sevier S., Kelly J. A., Glenn S. B., Aberle T., Cooney C. M., Grether A., James E., Ning J., Tesiram J., Morrisey J., Powe T., Drexel M., Daniel W., Namjou B., Ojwang J. O., Nguyen K. L., Cavett J. W., Te J. L., James J. A., Hal Scofield R., Moser K., Gilkeson G. S., Kamen D. L., Carson C. W., Quintero-del-Rio A. I., del Carmen Ballesteros M., Punaro M. G., Karp D. R., Wallace D. J., Weisman M., Merrill J. T., Rivera R., Petri M. A., Albert D. A., Espinoza L. R., Utset T. O., Shaver T. S., Arthur E., Anaya J. M., Bruner G. R., Harley J. B., The lupus family registry and repository. Rheumatology 2011 50 1 47 59 2-s2.0-79951706007 10.1093/rheumatology/keq302
25. McClain M. T., Heinlen L. D., Dennis G. J., Roebuck J., Harley J. B., James J. A., Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nature Medicine 2005 11 1 85 89 2-s2.0-13444287958 10.1038/nm1167 (Pubitemid 40215842)
26. Binder S. R., Genovese M. C., Merrill J. T., Morris R. I., Metzger A. L., Computer-assisted pattern recognition of autoantibody results. Clinical and Diagnostic Laboratory Immunology 2005 12 12 1353 1357 2-s2.0-29144529136 10.1128/CDLI.12.12.1353-1357.2005 (Pubitemid 41814204)
27. Bruner B. F., Guthridge J. M., Lu R., Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of SLE patients and family members. Arthritis and Rheumatism. In press
28. Bardin N., Desplat-Jego S., Daniel L., Jourde Chiche N., Sanmarco M., BioPlex 2200 multiplexed system: simultaneous detection of anti-dsDNA and anti-chromatin antibodies in patients with systemic lupus erythematosus. Autoimmunity 2009 42 1 63 68 2-s2.0-58149485195 10.1080/08916930802354906
29. Hanly J. G., Su L., Farewell V., Fritzler M. J., Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus. Journal of Immunological Methods 2010 358 1-2 75 80 2-s2.0-77953291702 10.1016/j.jim.2010.04.005
30. Hanly J. G., Thompson K., McCurdy G., Fougere L., Theriault C., Wilton K., Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus. Journal of Immunological Methods 2010 352 1-2 147 152 2-s2.0-71849102119 10.1016/j.jim.2009.10.003
31. Moder K. G., Wener M. H., Weisman M. H., Ishimori M. L., Wallace D. J., Buckeridge D. L., Homburger H. A., Measurement of antinuclear antibodies by multiplex immunoassay: a prospective, multicenter clinical evaluation. Journal of Rheumatology 2007 34 5 978 986 2-s2.0-34248655390 (Pubitemid 46774842)
32. Shovman O., Gilburd B., Barzilai O., Shinar E., Larida B., Zandman-Goddard G., Binder S. R., Shoenfeld Y., Evaluation of the BioPlex 2200 ANA screen. Analysis of 510 healthy subjects: incidence of natural/predictive autoantibodies. Annals of the New York Academy of Sciences 2005 1050 380 388 2-s2.0-23744482616 10.1196/annals.1313.120 (Pubitemid 41129457)
33. Lau C. S., Yin G., Mok M. Y., Ethnic and geographical differences in systemic lupus erythematosus: an overview. Lupus 2006 15 11 715 719 2-s2.0-39049185771 10.1177/0961203306072311
34. Kumar K., Chambers S., Gordon C., Challenges of ethnicity in SLE. Best Practice and Research 2009 23 4 549 561 2-s2.0-67649814985 10.1016/j.berh.2009. 04.005
35. Quintero-Del-Rió A. I., Bacino D., Kelly J., Aberle T., Harley J. B., Familial systemic lupus erythematosus: a comparison of clinical manifestations and antibody presentation in three ethnic groups. Cellular and Molecular Biology 2001 47 7 1223 1227 2-s2.0-0035524765
36. Kamen D. L., Barron M., Parker T. M., Shaftman S. R., Bruner G. R., Aberle T., James J. A., Scofield R. H., Harley J. B., Gilkeson G. S., Autoantibody prevalence and lupus characteristics in a unique African American population. Arthritis and Rheumatism 2008 58 5 1237 1247 2-s2.0-43949141221 10.1002/art.23416 (Pubitemid 351705912)
37. To C. H., Petri M., Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus? Arthritis and Rheumatism 2005 52 12 4003 4010 2-s2.0-29144445982 10.1002/art.21414 (Pubitemid 41798240)
38. Nalls M. A., Wilson J. G., Patterson N. J., Tandon A., Zmuda J. M., Huntsman S., Garcia M., Hu D., Li R., Beamer B. A., Patel K. V., Akylbekova E. L., Files J. C., Hardy C. L., Buxbaum S. G., Taylor H. A., Reich D., Harris T. B., Ziv E., Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies. American Journal of Human Genetics 2008 82 1 81 87 2-s2.0-38749132020 10.1016/j.ajhg.2007.09.003 (Pubitemid 351726080)
39. Reich D., Nalls M. A., Kao W. H. L., Akylbekova E. L., Tandon A., Patterson N., Mullikin J., Hsueh W. C., Cheng C. Y., Coresh J., Boerwinkle E., Li M., Waliszewska A., Neubauer J., Li R., Leak T. S., Ekunwe L., Files J. C., Hardy C. L., Zmuda J. M., Taylor H. A., Ziv E., Harris T. B., Wilson J. G., Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genetics 2009 5 1 e1000360 2-s2.0-59249102648 10.1371/journal.pgen.1000360
40. Reiner A. P., Lettre G., Nalls M. A., Ganesh S. K., Mathias R., Austin M. A., Dean E., Arepalli S., Britton A., Chen Z., Couper D., Curb J. D., Eaton C. B., Fornage M., Grant S. F. A., Harris T. B., Hernandez D., Kamatini N., Keating B. J., Kubo M., LaCroix A., Lange L. A., Liu S., Lohman K., Meng Y., Mohler E. R., Musani S., Nakamura Y., O'Donnell C. J., Okada Y., Palmer C. D., Papanicolaou G. J., Patel K. V., Singleton A. B., Takahashi A., Tang H., Taylor H. A., Taylor K., Thomson C., Yanek L. R., Yang L., Ziv E., Zonderman A. B., Folsom A. R., Evans M. K., Liu Y., Becker D. M., Snively B. M., Wilson J. G., Genome-Wide association study of white blood cell count in 16,388 african americans: the continental Origins and Genetic Epidemiology network (COGENT). PLoS Genetics 2011 7 6 e1002108 2-s2.0-79959812503 10.1371/journal.pgen.1002108
41. Haddy T. B., Rana S. R., Castro O., Benign ethnic neutropenia: what is a normal absolute neutrophil count? Journal of Laboratory and Clinical Medicine 1999 133 1 15 22 2-s2.0-0032948464 10.1053/lc.1999.v133.a94931 (Pubitemid 29032412)
42. Alba P., Bento L., Cuadrado M. J., Karim Y., Tungekar M. F., Abbs I., Khamashta M. A., D'Cruz D., Hughes G. R. V., Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis. Annals of the Rheumatic Diseases 2003 62 6 556 560 2-s2.0-0037809612 10.1136/ard.62.6.556 (Pubitemid 36606290)
43. Cooper G. S., Parks C. G., Treadwell E. L., Clair E. W. S., Gilkeson G. S., Cohen P. L., Roubey R. A. S., Dooley M. A., Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States. Lupus 2002 11 3 161 167 2-s2.0-0036220615 10.1191/0961203302lu161oa (Pubitemid 34296931)
44. Sestak A. L., Nath S. K., Kelly J. A., Bruner G. R., James J. A., Harley J. B., Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race. Lupus 2008 17 11 1004 1009 2-s2.0-61549133970 10.1177/0961203308091969
45. Li W. X., Pan H. F., Li L. H., Zhang N., Li J., Fan Y. G., Feng J. B., Tang X. W., Chen H., Li X. P., Ye D. Q., Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus. Irish Journal of Medical Science 2010 179 4 623 627 2-s2.0-78349312051 10.1007/s11845-010-0543-x
46. Tang X., Huang Y., Deng W., Tang L., Weng W., Zhang X., Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China. Medicine 2010 89 1 62 67 2-s2.0-74549164196 10.1097/MD.0b013e3181cb449c
47. Li W. X., Pan H. F., Li L. H., Zhang N., Li J., Fan Y. G., Feng J. B., Tang X. W., Chen H., Li X. P., Ye D. Q., Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus. Irish Journal of Medical Science 2010 179 4 623 627 2-s2.0-78349312051 10.1007/s11845-010-0543-x