Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

Journal of Oleo Science

Volumn 62, Issue 3, 2013, Pages 181-186

  Maoka, Takashi ^a   Yasui, Hiroyuki ^b   Ohmori, Aya ^b   Tokuda, Harukuni ^c   Suzuki, Nobutaka ^c   Osawa, Ayako ^d   Shindo, Kazutoshi ^d   Ishibashi, Takashi ^e  

^a RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d JAPAN WOMEN'S UNIVERSITY   (Japan)

^e JAPAN ENERGY CORPORATION   (Japan)

Author keywords

Adonirubin; Adonixanthin; Anti carcinogenic activity; Anti oxidative activity; Anti tumor promoting activity

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ADONIRUBIN; ADONIXANTHIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CANTHAXANTHIN; CAROTENOID; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MATRIX PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; SINGLET OXYGEN; DRUG DERIVATIVE; EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID PEROXIDATION; METABOLISM; MOUSE; PARACOCCUS; SKIN NEOPLASMS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CANTHAXANTHIN; CAROTENOIDS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LIPID PEROXIDATION; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; PARACOCCUS; SINGLET OXYGEN; SKIN NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE; VIRAL MATRIX PROTEINS;

EID: 84874907073     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.62.181     Document Type: Note

References (23)

1. Britton, G.; Liaaen-Jensen, S.; Pfander, H., Eds.; Carotenoids Volume 3: Biosynthesis and Metabolism, Birkhäuser; Basel, 1998; Vol. 3.
2. Egger, K. Die ketocarotenoids in Adonis annua L. Phytochenistry 4, 609-618(1965).
3. Egger, K.; Kleinig H. Die ketocarotenoids in Adonis annua L.-II: Zur Strukutur des Ester. Phytochenistry 6, 437-440(1967).
4. Britton, G.; Liaaen-Jensen, S.; Pfander, H., Eds.; Carotenoids Volume 5: Nutrition and human health, Birkhäuser; Basel, 1998; Vol. 3.
5. Britton, G.; Liaaen-Jensen, S.; Pfander, H., Eds.; Carotenoids Volume 5: Nutrition and Health, Birkhäuser; Basel, 2009; Vol. 3.
6. Hussein, G.; Sankawa, U.; Goto, H.; Matsumoto, K.; Watanabe, H. Astaxanthin, a carotenoids with potential in human health and nutrition, J. Natr. Prod. 69, 443-449(2006).
7. Yazawa, K. Ed. Ed.,"Asutakisanchin no kagaku(in Japanese)"Seizando, Tokyo, 2009.
8. Yoshikawa, T and Naito, J. Eds., The function and application of astaxanthin, CMC Publishing Co., Ltd. Tokyo 2012.
9. Tsubokura, A.; Yoneda, H.; Mizuta, H. Paracoccus carotinifaciens sp. nov., a new aerobic gram-negative astaxanthin-producing bacterium. J. Syst. Bacteriol. 49, 277-282(1999).
10. Maoka, T.; Etoh, T.; Osawa, A.; Shindo, K. Characterization and Singlet Oxygen Quenching Activity of(3R) -3-Hydroxy-4-Ketotorulene and(3R)-3-Hydroxy-4-Ketoto-γ-carotene from the Yeast Xanthophyllomyces dendrorhrous, J. Oleo Sci. 61, 401-406(2012).
11. Britton, G.; Liaaen-Jensen, S.; Pfander, H., Eds.; Carotenoids Volume 1B: Spectroscopy, Birkhäuser; Basel, 1998; Vol. 3.
12. Terao. J. Antioxidative activity of beta-carotene-related carotenoids in solution. Lipids 24, 659-661(1989).
13. 50 carotenoids-sarcinaxanthin, sarcinaxanthin monoglucoside, and sarcinaxanthin diglucoside-obtained from Micrococcus yunnanensis. J. Oleo. Sci. 59, 653-659(2010).
14. Hayashi, S.; Yasui, H.; Sakurai, H. Essential role of sin glet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes. Drug Metab. Pharmacokinet. 20, 14-23(2005).
15. Tsushima, M.; Maoka, T.; Katsuyama, M.; Kozuka, M.; Matsuno, T.; Tokuda, H.; Nishino, H.; Iwashima, A. Inhibitory effect of natural carotenoids on Epstein-Barr virus activation activity of a tumor promoter in Raji cells. A screening study for anti-tumor promoters. Biol. Pharm. Bull. 18, 227-233(1995).
16. Maoka, T.; Mochida, K.; Kozuka, M.; Ito, Y.; Fujiwara, Y.; Hashimoto, K.; Enjo, F.: Ogata, M.; Nobukuni, Y.; Tokuda, H.; Nishino, H. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L., Cancer Lett., 172, 103-109(2001).
17. Miki, W. Biological functions and activities of animal carotenoids. Pure Appl. Chem. 63, 141-146(1991).
18. Maoka, T.; Goto, Y.; Isobe, K.; Fujiwrara, Y.; Hashimoto, K.; Mochida, K. Antioxidative activity of capsorubin and related compounds from paprika(Capsicum annuum). J. Oleo Sci. 50, 663-665(2001).
19. Shimidzu, N.; Goto, M.; Miki, W. Carotenoids as singlet oxygen quenchers in marine organism. Fish. Sci. 62, 134-137(1996).
20. Nishino, H. Cancer prevention by carotenoids. Mutat. Res. 402, 159-163(1998).
21. Tanaka, T.; Morishita, Y.; Suzuk, M.; Kojima, T.; Okumura, A.; Mori, H. Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Carcinogenesis 15, 15-19 (1994).
22. Tanaka, T.; Makita, H.; Ohnishi, M.; Mori, H.; Satoh, K.; Hara, A. Chemoprevention of rat oral carcino-genesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin. Cancer Res. 55, 4059-4064(1995).
23. Tanaka, T.; Kawamori, T.; Ohnishi, M.; Makita, H.; Mori, H.; Satoh, K.; Hara, A. Suppression of azoxymethaneinduced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase. Carcinogenesis 16, 2957-2963(1995).