Dual-site interactions of p53 protein transactivation domain with anti-apoptotic bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways

Journal of Biological Chemistry

Volumn 288, Issue 10, 2013, Pages 7387-7398

  Ji Hyang Ha, ^a,b   Shin, Jae Sun ^a   Yoon, Mi Kyung ^a   Lee, Min Sung ^c   He, Fahu ^a   Bae, Kwang Hee ^d   Yoon, Ho Sup ^b   Lee, Chong Kil ^a   Park, Sung Goo ^a,c   Muto, Yutaka ^c   Chi, Seung Wook ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

^c RIKEN   (Japan)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PATHWAYS; ATOMIC LEVELS; BCL-2 FAMILY PROTEINS; P53 PROTEIN; STRUCTURE CALCULATION; TRANSACTIVATION DOMAIN;

CELL DEATH; TRANSCRIPTION;

PROTEINS;

E1A ASSOCIATED P300 PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MDM2; PROTEIN P53;

ALPHA HELIX; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; HUMAN; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; BINDING SITES; BINDING, COMPETITIVE; CALORIMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84874866274     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.400754     Document Type: Article

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